ID A0A2B7XYW5_9EURO Unreviewed; 1549 AA.
AC A0A2B7XYW5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=AJ79_03252 {ECO:0000313|EMBL:PGH14135.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH14135.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH14135.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH14135.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH14135.1}.
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DR EMBL; PDNB01000038; PGH14135.1; -; Genomic_DNA.
DR STRING; 1447875.A0A2B7XYW5; -.
DR OrthoDB; 24699at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR021895; Bud3_N.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR22834:SF21; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED; 1.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF12015; Bud3_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968}.
FT DOMAIN 243..461
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 819..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1165..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1503..1537
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 823..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1549 AA; 170728 MW; 8666B9CA0BE86AC2 CRC64;
MASVSTSIAG LPLEQLTLYH APDPILSSVL VFYGPVITAN STVRSSRFQA HIITPGGLQS
YPRITISPAA PLYAAVNHLP RDKQGDEVYR GLAVCLLKYF GDLSEPVRYV LLGTARSGKL
SARSPNTFDE VHAADLANKM LKVEDPTDII RDLKDAYSDR IVPWIDVDLV MPPGSIVMSN
VPRTSDCDLE PQEEFTLQYG KYNSLIERLG DPVFLPTSKL RRAPSQPINS SKSKLFSATQ
KETLRLAMCE VVDTEERFVG KMYDLVHNII QKFYQKAADK PPTSTSPDEV ALKQLFPPCL
NEILEVNMGF LGEIRQVLEQ TEKEALEDLS VDTEINSSSF RRDSKGNRRD PIGIIQFAHA
LLEWFPRFSQ PYGDYMHAHH AFSQTLSSFL GDNHSSFSKR VYETGEQKMR SILMEPVQRL
PRYSLLIDAM TSALPSVHPA VRTLLKARDI ITEICSLDSH SSNNKSQSLQ RLQSLVEDLP
TSSLPSGRLI AAADFYELSP PYQLSSPVGR SEPGILLLYG DYLILLSKSL DSRMTARGLY
AELDKPTVAS TDEEAAPFEL KFSQALRITN LRCTQSTCGR ILYLTPAGNF VQNERSRFGA
AMHALELSST YEGKASRLIE EITKVKIEGR FPEQYRERSK WALRSFKGGI SNLGVLISVF
EDEPKELGGQ NTSSAVKVIF DGTKAVRSKE LSRPEVEVIA SISMSSNDKY KLDIDSVVGV
STTDSFTAAE FIPVLSNRLN NLLRPLHQPE NPILTSAILN TNFNIIRAIT SYLLGNAKGR
GFRPPSPTKF LSNFWNGSPK SSLPPSRSLL PAPVLREIPQ ILPPDSDSSN ATIPRPTSSR
GMDKSDTTLF GVNVGEKPQD TFKSLEETFA AYVIAIRSRC GNIVGRVLRN RRQADATTVN
ELYNALLEDA GKIQLAAESP VDVLFVAFET FMVQVWNEHI GPIISPTALQ AIQSKFDSMF
PGDFEDYFHG FLTEMSPQNR RALTALVKLL AELLDGSGND GDRGALTATF TEILTEKGDA
MEHISLLDRL VEDFDRLFDD GGVLSASIEG IHISDPMTPL ARTQSVNAGA SNSGSISSNT
SSFRRRFGFG GSRDRGKSES EGKVSSIIRT LSKSKHGESD SQPSSLSKAS LFRSRSIDTD
SRLANLLRPV SRERLLAHGL FSASAEDQSL RPNSSHSNAP TLASIGEDYP IDKPVTVKKK
RRSSLSDLKP PPPANPGTLL PAIDLRRPLT PTSPPNCKPS PETCSPVRQL KQANGVGPQT
PKRTTVTNPS PARATASPRK ENAPPTPRMT LGERALNRKS NPVGLPQLSP KRRSETQSSI
PSPRNTLFKE RVALTNRAEI ANSHPQSSSS PQRTPRLRMQ NPQKLRERLQ SEKRAIATAE
STLQNEITSI ADEISSPRTS PIKRRPTTPK PVSSPPPASN STATLPTRVR SLETKAATML
SELTSRTSVL EKEIEDSLLV SERRAKKLDE LYREASAENT ALYERFNAEL TNVTKEVRIG
AGEEALKTQL KEALDEVARV KKENMRLKRE IGGLKAQQLD PLNGDGHHT
//
