ID A0A2B7Y5G7_9EURO Unreviewed; 1082 AA.
AC A0A2B7Y5G7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ATP-dependent RNA helicase DOB1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AJ79_01801 {ECO:0000313|EMBL:PGH16470.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH16470.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH16470.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH16470.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH16470.1}.
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DR EMBL; PDNB01000017; PGH16470.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7Y5G7; -.
DR STRING; 1447875.A0A2B7Y5G7; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968}.
FT DOMAIN 165..321
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 434..606
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 122816 MW; 068DD45657C810B6 CRC64;
MDDLFDVFED KPSSGFPPQE PLKPRAKKDK NKKRQANGVV KDSPNAGSAQ ENGEIVVDTP
MEDKTPEDVT EPQNGQPDAK RQRLQPEPET VVADTFETEQ SREIAGSAGL QATQDTKAVV
LSHQVRHQVA LPPDYPYVPI SEHKPPETPA RSWPFTLDPF QQVSIASIER GESVLVSAHT
SAGKTVVAEY AIAQSLKNNQ RVIYTSPIKA LSNQKYREFA AEFGDVGLMT GDVTINPTAT
CLVMTTEILR SMLYRGSEIM REVAWVVFDE IHYMRDKTRG VVWEETIILL PDKVRYVFLS
ATIPNAMQFA EWITKMHNQP CHVVYTDFRP TPLQHYFHPA GAEGIHLIVD EKGVFREENF
HKAMEKIAEK QGDDPANVNA KMKGKGKNKK INKGEDKKGP SDIYKIVKMI MLKNYNPVIV
FSFSKRECEA FALQMSKLAF NDESEKEMVS KVFNSAIEML SDEDKELPQI KHILPLLRLG
IGVHHSGLLP ILKETIEILF QEGLIKVLFA TETFSIGLNM PAKTVVFTSV RKFDGVSQRW
ITPSEFVQMS GRAGRRGLDD RGIVIMMINE EMDPTVAKEI VRGEQDKLNS AFYLGYNMIL
NLLRVEGISP EFMLERCFYQ FQNTASVAGL EKPELAELEK EHAGMVITDE GTIREYYELR
QNIATYTSDM QTVISHPSYS LKYMVSGRLV QIKYMDYDFG WGAVVNYKNR RPPQNAPNEE
YPPHESYIVD VLMPIADGSS SITRKNVQPL PPGVRPAQAG EKVRLEVVPV LLTCVKAISH
VRIKLPQDLK PPNVRSSLKK NIAEIQRRFP DGIPLLDPIE DMEINDDSFK KLLRKIEVLE
SRLISNPLHN SPRLPELYDQ YAAKLEQQSK IKETKKKIAE AMSIIQLDEL KCRKRVLRRF
QFINEAEVVQ LKARVACEIS SGDELMLSEL LFNGFFNNLS PELCAAVLSV FVFEESSKEA
QPISKEELAK PLREIQAQAR TIAKVSQESK LAVNEDEYVK SFRWELMEVI YEWAHGKSFA
EICKMTDVYE GSLIRTFRRL EECMRQMAQA AKVMGSEDLE KKFEKSLEMV KRDIVAAQSL
YL
//
