ID   A0A2B7Z0Y5_9EURO        Unreviewed;       510 AA.
AC   A0A2B7Z0Y5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=NCS1 family nucleobase:cation symporter-1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GX50_07233 {ECO:0000313|EMBL:PGH30014.1};
OS   Emmonsia crescens.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX   NCBI_TaxID=73230 {ECO:0000313|EMBL:PGH30014.1, ECO:0000313|Proteomes:UP000226031};
RN   [1] {ECO:0000313|EMBL:PGH30014.1, ECO:0000313|Proteomes:UP000226031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH4076 {ECO:0000313|EMBL:PGH30014.1,
RC   ECO:0000313|Proteomes:UP000226031};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC       {ECO:0000256|ARBA:ARBA00008974, ECO:0000256|PIRNR:PIRNR002744}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH30014.1}.
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DR   EMBL; PDND01000197; PGH30014.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7Z0Y5; -.
DR   STRING; 73230.A0A2B7Z0Y5; -.
DR   VEuPathDB; FungiDB:EMCG_04237; -.
DR   OrthoDB; 65220at2759; -.
DR   Proteomes; UP000226031; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd11484; SLC-NCS1sbd_CobB-like; 1.
DR   Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   PANTHER; PTHR31806; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR   PANTHER; PTHR31806:SF1; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000226031};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002744}.
FT   TRANSMEM        74..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        375..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   510 AA;  56185 MW;  307D1B8DE89F397F CRC64;
     MSHDAFTDIE IGSAREYPEQ NDEQEYAPAE DIEIEKGFIT KLQRFTGKYG VEQRGIEPVL
     EHERTDTTVL RLGMLWFACN IAVSSFAIGI LAVPVFGLGF VDGFLVILFF NILGILPVCF
     FSTLGARLGL RQMVLSRFYF GYYGVKLAAL LNFFACLGWS AVNVIVGAQL IQAVNNDVPS
     WAAIIIIGSA TFIVSVFGYK VVHIYESFCW IPAFIVFMVV LGIFAHSGDF ENLPLKTGTS
     ETASVLSFAS AVFGFSTAWA IISADYCVYQ PITVSQKKIF FTVFCGLFPA LIFTQALGLA
     IATATVNNPA YAAAYNDNHV GGLLAHVLFP RLGSFGKFCL VILALSIIGN NCPNMYSLGF
     CLQILHSQTQ RVPRYVWSFA GTLVYIGVAI PGFFHFETVL ESFMLIIGYW SAVYEGISLG
     EHIMFRRGTS PYNVEDYDTP SRLPPSFAAV GAFCCGVMGV VVGMSQRWFV GPIAKRIDAS
     GADIGFELAF GFTLVSFLIF RTMERSYFKR
//