ID   A0A2B7ZEP3_9EURO        Unreviewed;       667 AA.
AC   A0A2B7ZEP3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN   ORFNames=GX50_02182 {ECO:0000313|EMBL:PGH34944.1};
OS   Emmonsia crescens.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX   NCBI_TaxID=73230 {ECO:0000313|EMBL:PGH34944.1, ECO:0000313|Proteomes:UP000226031};
RN   [1] {ECO:0000313|EMBL:PGH34944.1, ECO:0000313|Proteomes:UP000226031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH4076 {ECO:0000313|EMBL:PGH34944.1,
RC   ECO:0000313|Proteomes:UP000226031};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC       known as the alpha DNA polymerase-primase complex) which plays an
CC       essential role in the initiation of DNA synthesis.
CC       {ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC       {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH34944.1}.
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DR   EMBL; PDND01000030; PGH34944.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7ZEP3; -.
DR   STRING; 73230.A0A2B7ZEP3; -.
DR   VEuPathDB; FungiDB:EMCG_04418; -.
DR   OrthoDB; 49016at2759; -.
DR   Proteomes; UP000226031; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.60; -; 2.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016722; DNA_pol_alpha_bsu.
DR   InterPro; IPR013627; Pol_alpha_B_N.
DR   PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR   PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF08418; Pol_alpha_B_N; 1.
DR   PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000226031}.
FT   DOMAIN          22..266
FT                   /note="DNA polymerase alpha subunit B N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08418"
FT   DOMAIN          373..610
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  72416 MW;  77998ECE74262020 CRC64;
     MEDTVSELND AFSGSCPSGV PQDVATELRS IMRLHSMSAQ DLSYKWDAYC LKMGTEETTL
     SLDTVRGLKR DVQDTLERES RGKSHMRGAD KRSAISATPR AAANTRDVFG MLDDFVPSPH
     DRTTNGATAS AGKRKAAFGT PSTSKMGRVE KGIGSLADSQ TPLRLSNGDL AGLLPTPFSE
     RQNSGQVLET INNHLPMPQP PIAPYPVERI KPAANTDLKK FAYKPMSMHA NEASEVLDNM
     IDEFMAIIQK HHGLDDTSFG SAANQSTKEI VAVGRIASDS LEGKLNTASL VLETSRRKGA
     GSRVPLKVDS LPSVQFFPGQ IVALRGINAS REYFTVFEVL STPPLPPAAS PPAIIQSIND
     RLGGSDAERA LNILIASGPF TADDNLDFEP LRTLCAKAAD EYADALILTG PFLDLEHPLV
     ASGDFDLPDI KGLNPDNATL SSLFQCYITP LLKQLASAVP SICIFLVPSV RDAISKHVSF
     PQEKLPKKDL DLSQTKQVRT VPNPVTLSLN ESVFGMCSHD VLYELRQEEV LGGKPSEGGL
     LTRLSRYLIE QRHFLPVFPT TARGNLPKSG VEGGLATGAM LDISYLKLGE WWNARPDVLI
     TPSILPPFVK VVEGVLVINP GTLSKRKAAG SYAQMTLHPR TLTEEEMNVK QVGHKVYDRA
     RVDVIRI
//