ID A0A2B7ZTL9_9EURO Unreviewed; 2153 AA.
AC A0A2B7ZTL9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA repair protein rad8 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GX50_00569 {ECO:0000313|EMBL:PGH36533.1};
OS Emmonsia crescens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX NCBI_TaxID=73230 {ECO:0000313|EMBL:PGH36533.1, ECO:0000313|Proteomes:UP000226031};
RN [1] {ECO:0000313|EMBL:PGH36533.1, ECO:0000313|Proteomes:UP000226031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH4076 {ECO:0000313|EMBL:PGH36533.1,
RC ECO:0000313|Proteomes:UP000226031};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH36533.1}.
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DR EMBL; PDND01000006; PGH36533.1; -; Genomic_DNA.
DR STRING; 73230.A0A2B7ZTL9; -.
DR VEuPathDB; FungiDB:EMCG_06279; -.
DR OrthoDB; 103295at2759; -.
DR Proteomes; UP000226031; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45626:SF26; FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000226031};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1884..1921
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1971..2124
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 26..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2153 AA; 242872 MW; BDFD1E1048117BF4 CRC64;
MMTQEEALFH FLETVQEFIM DEVVTDPSDE GRSVDSNVNT GTCTSLNTDL ETETSLSEDA
GNEDANISEE GDLKILINSP PEILRGKYSS VPGKKPKPGL NFDLPPISKI EDIFDDISIN
AERNGFSNFL EHIGSRDLRV ATMCSGTEAP LLALEMVMSS FKRIFGKAFN MHHLFSAEID
PFKQSYIQRN FSPDIIFRDV NELIADEATT AFGSLRKVPA NLDLLVVGFS CVDFSNMNLH
RKTLDEMGES GHTFYGVLRY TQRCRPPLVI LENVCGAPWD HIKDAFKEMN YHAYHIKVDT
KNYYLPQTRE RGYMLCIDQA RLETPPPADS KSSPFAKMMK NFERPASSPV TQFLLKNNDP
RLQDAIDDIS SSPIKDRQAV DWTRYKARHL RYRMREGLGD KRPLTRWQDN GTCQMPDFYW
HGWSRTQTER VWDTLDVNYL RSIVRGFDIN FKSRIIDLSQ GLDRELDQRA SGVSGCLTPR
GQHFVTSRGG PLLGIEALAL QGIPIDRLLL SNDSQRDLND LAGNAMSSTV VGAAIMSALI
IGYKALGPDR TFRSNSKMEE RFTPQMKVAD SEALEMTPIQ LGDETALSPR EILEIGKRSS
RMCICEGQVL TKRTDMLTCL KCGLTACKSC GRNPPHAYSP IPTDELNERI CPIDFETQLK
QKLPMRLQVN GLSLAMYQAL REDNMSVDIM TAWEDFFKVL LPALGDELRF QEVTRQRSWT
ITYKGSLSVL KLVCSSTRLQ WFLYLTSPKD EPSNSPLRQI LLYPIASMAP SGKNILNGIW
HIKSPVSSYF DIAVSGSGNL VPSIGSRSGL KHSHFAGAKV WNQINISATN AAIKNLEFDI
RGEYELLQDC GAASGSLHKK AVAGFEPPVY FFLDPTEIGP TEFDSWVFAL DHDRLDIGEP
RITIAEVHSN WDPFTISNKP TSVRCWLRKT TTDDTISLDV YSSASPAIYQ TPTPQTIVKN
VGSKCLDSYV PMLTCSIPAS GAELAWEPGE WRASNLMESP TVLRKLAWLL QRANSVNQIS
EWNVICLNNE DYSKECGICA PRKPRLIWAL DDKNRIYAYE NPEDAAVYEQ SIKKRPATFL
GFTRLGHDSI LHVKLCLNVI TLIHQARGKL VKKDQVSLQW RLSIDNVGFL RQRLPTLWEK
NNKADTESIQ PPGFKFFNLR PEQLRSLTWM KEQEDTVQPF QEEEVVEAML PAVNWRAEVK
ATTKHLVRGG ILGDDVGYGK TAITLGLIDS QFAKDSKNVP SSVEGAIPIK ATLIVVPQHL
IDQWSREITK FLGKKYNVLE IKSIASLRSL TIRRFEIADI VLLSTSVVRG ASYYDRMELF
AATPAVPKGD GRIFDEWLVD TMAAVRDHVG LLLKEGSGLM LQNIIRKQSN LKNSGVYSKF
KPSRRFKGQR LQDHLLNLKD KMRNNGGDSV ATDKIDNHSE LRLTNPQLKL QNRKRKVVED
DEEYQSNIAN DKTAKAAEAK RMKIRTKPVT EGPGIEADKT FQLLNCNSDW KKMRSPLIHM
FEYNRLVIDE FTYSKDRNYS SVLAIPARSK WILSGTPPLN DFADVKSFSP FLGITLGVDD
DERGKTENER LRTIQREQTD AEQFQPFVTR HSAAWHGRRH DNTPGIDEIP WTEHIWPVIL
APRQRAAYLE LFMQLMSQNL KLRRNGRGLY DSSAMARNDA ILGNSSGPEE ALIKCSSHFV
PLEKIMGKRL IDKTKTKGLK TDESSTPSRA SSIFESNDRR NSRTPETDLT SICPDKENID
FARDRQLDDV VLDIIGKLRH AFWLRSKIEA TTHFDTLIKH LERNGAGDLG VTKCFRNAIV
AARITQTPED GRYYYLSAQE KKQNPSDIRL EYPKTPSEFI SDLNTCTDSL RRLVDETLIR
VRAARLFVVV RSFQDRHPDD VFACSSCFRR LTDPTPLSIL GECGHVFCKA CIEVAKVEET
CRLPACSGGA ESFRMIKYSD VGFIKNKDTN NNVNGEKWQE YGGTKLLELI RLVQDTDRIP
EDEQVLLFIQ FPDLMEAASA ALGKANITHL MIPVNDRMAS SKIAEFQTGT ENVKSKVLIL
HLGDVSASGL NLQNSNHVIF FHPLFAKSQY DYTSGMAQAI GRARRYGQQK HVHIHHFLAL
KTIEVNIFEQ RRRERLVKRD GGFLSLPAGE ALLPTDDAKW GGSSLAGSNS DGV
//
