ID A0A2B8ARQ9_9ACTN Unreviewed; 505 AA.
AC A0A2B8ARQ9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Polyketide cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CRI70_23550 {ECO:0000313|EMBL:PGH48351.1};
OS Streptomyces sp. Ru87.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2044307 {ECO:0000313|EMBL:PGH48351.1, ECO:0000313|Proteomes:UP000222409};
RN [1] {ECO:0000313|EMBL:PGH48351.1, ECO:0000313|Proteomes:UP000222409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ru87 {ECO:0000313|EMBL:PGH48351.1,
RC ECO:0000313|Proteomes:UP000222409};
RA Amin D.H., Borsetto C., Abolmaaty A., Tolba S., Abdallah N.A.,
RA Wellington E.M.H.;
RT "Draft genome sequence of Streptomyces sp. Ru87 isolated from Egyptian
RT soil.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH48351.1}.
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DR EMBL; PDIX01000390; PGH48351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B8ARQ9; -.
DR OrthoDB; 4145676at2; -.
DR Proteomes; UP000222409; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd08860; TcmN_ARO-CYC_like; 1.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000222409};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 11..125
FT /note="Coenzyme Q-binding protein COQ10 START"
FT /evidence="ECO:0000259|Pfam:PF03364"
FT DOMAIN 280..486
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT REGION 146..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 55436 MW; 0C5CF619E479CF45 CRC64;
MAASTDNAVV IRAPLQLVWD MTNDIESWTW LYTEYAAAEI LHREGDTVRF RLSMHPDADG
TVWSWVSERT ADPETRTVRA RRVEPGPFEH MDIRWEYTEV ETGTRMRWRQ DFAMKPTAPL
DDAAMAQRIN TNSAIQMARI QALVEQAAAD AGQDRPAAPP DDATQPPDHA SQPPQEQVFT
LLAGKWTAQA VSALARLGIA DLLADGPRTP EELAAATGTH AQSLHRVLRA AALVHVFTER
PDGTFALTPQ AETLRAGVPG SMRAFAALIG DDATWRPYGD ILETIRTGEP AFDRVHGATV
YEYFARHPET GAVFDEAMTA LSEESAGAYL GSYDFGRFAR VADIGGGRGQ MLAEILRLNP
GARGLLLERP DVVEQAQPLL RKHGVADRVE VVAGDFFTEV PPGADAYVLK TVLHNWNDAD
ALRILRNVRA AVGDDRDARL LVLEDVIQPL NAWDVGKLID IDMLVNVGGR GRTREDWERL
FTAAGFTLRL PEGAAAWSVL EGIPA
//
