ID   A0A2C1JNS3_9BACI        Unreviewed;      1009 AA.
AC   A0A2C1JNS3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Multidrug transporter AcrB {ECO:0000313|EMBL:PGT81875.1};
GN   ORFNames=COD11_16170 {ECO:0000313|EMBL:PGT81875.1};
OS   Bacillus sp. AFS040349.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2033502 {ECO:0000313|EMBL:PGT81875.1, ECO:0000313|Proteomes:UP000222674};
RN   [1] {ECO:0000313|EMBL:PGT81875.1, ECO:0000313|Proteomes:UP000222674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AFS040349 {ECO:0000313|EMBL:PGT81875.1,
RC   ECO:0000313|Proteomes:UP000222674};
RG   Agbiome Team Llc;
RA   Bleich R.M., Grubbs K.J., Santa Maria K.C., Allen S.E., Farag S.,
RA   Shank E.A., Bowers A.;
RT   "Large-scale bioinformatics analysis of Bacillus genomes uncovers conserved
RT   roles of natural products in bacterial physiology.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGT81875.1}.
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DR   EMBL; NUMC01000074; PGT81875.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C1JNS3; -.
DR   OrthoDB; 9757876at2; -.
DR   Proteomes; UP000222674; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF0; SWARMING MOTILITY PROTEIN SWRC; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000222674};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        326..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        451..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        833..852
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        859..881
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        887..907
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        928..949
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        961..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1009 AA;  109834 MW;  136908BED16A9EA9 CRC64;
     MSWFTKWSFK NKAAVFLMST LILVMGVLSY FRLPMEFLPS ADQPFISVVT MGNGVDAKTM
     EDQVTTPIEN AMDGVNGKRN VFSTTGDGYS SVDIHLESKI DKKEAKREIE EALANVQLPQ
     NVMKPNIVQL NTSMIPVSYI ALTFDKGINP ETIQYAQDEI VPYFKNIDGV ADIQTNGIIP
     SFVSVELDEK KMAEKQVSIE SIMTLLQGQN VSASIAENTV DGKASNIKVI GDVNTIEKLE
     NTEVIPGAAL KDIAEIKIEK QDNNLTKVNG SDALTFVITK DSQSNAVTIS KEAEKVSEEI
     NEKYNQLETT VVLASADMVE SSVHSMIKEV LLGALFATIV IMIFLRNLRS TLITIVSIPL
     SLGFTLFLLA QSGVTLNILT LGGVAVAVGR LVDDSIVVIE NIFRRAQTEK FSVKMVIDAT
     KEVGSAITSS TLTTVAVFLP MGLIGGSLQD FLLPFALTIT YSLLASLIVA LTIVPVMSAG
     LLKNAKMIEH KPSVKFTRFL TWSLNHKWVV LLTSFILFAG SIGGYMLLPK GSVDKTKADY
     VYVSLKYPNE TPIEKVKEES SKLEEFVMEQ DELENVYLQL GNSADSAKYG EVGDPTQTQI
     MAILKEDADM QAFIDKVNTQ KEEYKDATLE VTEASMMSGG STSITVDVIG EDVKELTDLS
     ETITAEINGI DGVEKVSSNQ EETKTVYSFV VNPSLAKADQ IAQQASVMLN QTPLGTIEVN
     DQQTMVMLEP VYTPDTEKDL SEVPIMTANG MTTISKVAQL QQTEEPTSTF HKDGEQYVRV
     TANVNPEKLS EISTEVNSKI FGDKETEGID IPDDIDVFVG GASADQASDF NDLFMTMLAS
     IGIVFLIMVI TFKTIRAPIA ILFSLPLAAI GAILGIMISG ISVDVTALLG ALMLIGIVVT
     NAIVLLDRVK QNEKTMIIRD AVVEAATIRM RPIIMTAVAT ISAMLPLLFK EAESGNLVSA
     SLAIVVIGGL SVATLLTLVV IPVVYELLYF RKSKKQRNQV KKQEDTIAV
//