ID A0A2C1L225_9BACI Unreviewed; 934 AA.
AC A0A2C1L225;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=COD11_00140 {ECO:0000313|EMBL:PGT92019.1};
OS Bacillus sp. AFS040349.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2033502 {ECO:0000313|EMBL:PGT92019.1, ECO:0000313|Proteomes:UP000222674};
RN [1] {ECO:0000313|EMBL:PGT92019.1, ECO:0000313|Proteomes:UP000222674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AFS040349 {ECO:0000313|EMBL:PGT92019.1,
RC ECO:0000313|Proteomes:UP000222674};
RG Agbiome Team Llc;
RA Bleich R.M., Grubbs K.J., Santa Maria K.C., Allen S.E., Farag S.,
RA Shank E.A., Bowers A.;
RT "Large-scale bioinformatics analysis of Bacillus genomes uncovers conserved
RT roles of natural products in bacterial physiology.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGT92019.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NUMC01000001; PGT92019.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C1L225; -.
DR OrthoDB; 9759607at2; -.
DR Proteomes; UP000222674; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000222674};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..365
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 370..441
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 445..497
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 529..662
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 671..925
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 934 AA; 106666 MW; BD7E70052C9D81BD CRC64;
MNLNFNVSNI VKSRLFKRTF LFLFISIIFF SGFIYVASSI ILPKIAQDQY REMTDLAVHR
LSNHAKMIVE NANAISETNK QNEDLLQDDS LVLNSELTKL LDSSPFFDGG TMTDVEGEIL
VSRNLNLNEF ITKSGIKYEP QIGTEETLHF SDVLVNKSDK KESIILLSFP VNNEKEEVKR
IVHMAIHLDQ KGLFQSMFKE LNIGKDSYAY IVDSKGTLIS HPQREMLGED VSDNPAVQAI
LKKKTGYMGL INQFDVEMYS SYQYIPGLEW GIVAQVPSET TYLGVKKFHE SLWLSSIILI
ILLTFLAAIH TVKTMNPIRK LHYAVDQVAK GNFRSEIEND ESKGEIGALI KRFNEMITSL
NHAKKQLKSQ KNFLSKIISK SPNAIYVVDY NGRFTLANEA FTKLLGTTPA EIVGKKESEF
NPDEEEVERY FQINREVINS KKDRFIPEAS LTDSEGNQHW MQVMKIPIIE EDGSSHSLLC
FATNITERIM NEEKIKFHAS HDSLTQLPNR YKFKKALEQE LELAYDEQMN VAVLFMDLDR
FKYVNDHFGH MMGDKLLQAV TSRLKENLHE RDTISRFGGD EFTVILSNID DKDQVSSIAN
KLIHALGQPY QIDGHSLVTT TSIGISMYPN DGEDVDILIK NADTAMYQAK NQGKNTYRYF
HSEMNSLLSN KYKLENYMRD ALEKEEFHLF YQPKMDTHTG KISGIEALLR WEQKELGMVS
PSEFIPIAEE SGLILQVGEW VLEQACLQNK RWQDEGYPPI KVSVNLSVWQ IKHSDIVKTV
QQILEKTGLN PIWLELEITE TAIMENKRSI LRTLKQLKKM GVSIAIDDFG TGYSSLNYLK
RFPVDTLKID RSFIQGILTE QDDTVIATAV ISMATKLGLI VVAEGVETDE QLHYLHDLHC
NEVQGFLISP PVPKNQMTKM LEKELLYYMS KTVS
//
