ID A0A2C1YXH6_9BACI Unreviewed; 318 AA.
AC A0A2C1YXH6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=UV DNA damage endonuclease {ECO:0000256|HAMAP-Rule:MF_00606};
DE Short=UV-endonuclease {ECO:0000256|HAMAP-Rule:MF_00606};
DE Short=UVED {ECO:0000256|HAMAP-Rule:MF_00606};
DE EC=3.-.-.- {ECO:0000256|HAMAP-Rule:MF_00606};
GN Name=uvsE {ECO:0000256|HAMAP-Rule:MF_00606,
GN ECO:0000313|EMBL:PGV49621.1};
GN ORFNames=COD92_21155 {ECO:0000313|EMBL:PGV49621.1};
OS Bacillus sp. AFS037270.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2033499 {ECO:0000313|EMBL:PGV49621.1, ECO:0000313|Proteomes:UP000225442};
RN [1] {ECO:0000313|EMBL:PGV49621.1, ECO:0000313|Proteomes:UP000225442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AFS037270 {ECO:0000313|EMBL:PGV49621.1,
RC ECO:0000313|Proteomes:UP000225442};
RG Agbiome Team Llc;
RA Bleich R.M., Grubbs K.J., Santa Maria K.C., Allen S.E., Farag S.,
RA Shank E.A., Bowers A.;
RT "Large-scale bioinformatics analysis of Bacillus genomes uncovers conserved
RT roles of natural products in bacterial physiology.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC phosphodiester bond immediately 5' to the lesion.
CC {ECO:0000256|ARBA:ARBA00025029}.
CC -!- FUNCTION: Component in a DNA repair pathway. Removal of UV-light
CC damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC phosphodiester bond immediately 5' to the lesion. {ECO:0000256|HAMAP-
CC Rule:MF_00606}.
CC -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000256|HAMAP-
CC Rule:MF_00606}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGV49621.1}.
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DR EMBL; NUNF01000044; PGV49621.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C1YXH6; -.
DR Proteomes; UP000225442; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009411; P:response to UV; IEA:InterPro.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR HAMAP; MF_00606; UV_endonuclease; 1.
DR InterPro; IPR004601; UvdE.
DR InterPro; IPR023520; UvdE_bac.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR NCBIfam; TIGR00629; uvde; 1.
DR PANTHER; PTHR31290; UV-DAMAGE ENDONUCLEASE; 1.
DR PANTHER; PTHR31290:SF5; UV-DAMAGE ENDONUCLEASE; 1.
DR Pfam; PF03851; UvdE; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00606};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00606}; DNA repair {ECO:0000256|HAMAP-Rule:MF_00606};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00606}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00606};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00606}.
SQ SEQUENCE 318 AA; 36743 MW; 10BA797E54F1C7B6 CRC64;
MKIRFGYVSH AISLWGASPA HTLTFTRYKQ HTAAERKEKL LEVTKLNLQH TLRMLYYNLA
HEIELYRFSS SIVPLATHPE VRWDFTTPFL KEWQEIGDLV KRNHLRVSFH PNQFTLFTSP
KKTITENAVI DMTYHYQMFE AMGIVDQALI NIHIGGAYGD KAAAVSRFYE NLTTLPAHIK
KVMTLENDDK TYTAEETLEV CKKEGIPLVF DYHHHMANLS EVPLEELLPQ IFETWPTVEA
VPKVHISSPK NEKEFRSHAD FVDPEFIMPF VNLLRELGRD IDFMIEAKAK DQAALKLVED
LSKLRGFKRI SGASLEIK
//
