ID A0A2C5WUY2_9PEZI Unreviewed; 620 AA.
AC A0A2C5WUY2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN Name=AMPP {ECO:0000313|EMBL:PHH49520.1};
GN ORFNames=CFIMG_004104RAa {ECO:0000313|EMBL:PHH49520.1};
OS Ceratocystis fimbriata CBS 114723.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Ceratocystidaceae; Ceratocystis.
OX NCBI_TaxID=1035309 {ECO:0000313|EMBL:PHH49520.1, ECO:0000313|Proteomes:UP000222788};
RN [1] {ECO:0000313|EMBL:PHH49520.1, ECO:0000313|Proteomes:UP000222788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114723 {ECO:0000313|EMBL:PHH49520.1,
RC ECO:0000313|Proteomes:UP000222788};
RX PubMed=23931120; DOI=10.1016/j.funbio.2013.06.004;
RA Simpson M.C., Wilken P.M., Coetzee M.P., Wingfield M.J., Wingfield B.D.;
RT "Analysis of microsatellite markers in the genome of the plant pathogen
RT Ceratocystis fimbriata.";
RL Fungal Biol. 117:545-555(2013).
RN [2] {ECO:0000313|EMBL:PHH49520.1, ECO:0000313|Proteomes:UP000222788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114723 {ECO:0000313|EMBL:PHH49520.1,
RC ECO:0000313|Proteomes:UP000222788};
RX PubMed=24563841; DOI=10.5598/imafungus.2013.04.02.14;
RA Wilken P.M., Steenkamp E.T., Wingfield M.J., de Beer Z.W., Wingfield B.D.;
RT "IMA Genome-F 1: Ceratocystis fimbriata: Draft nuclear genome sequence for
RT the plant pathogen, Ceratocystis fimbriata.";
RL IMA Fungus 4:357-358(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH49520.1}.
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DR EMBL; APWK03000193; PHH49520.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5WUY2; -.
DR STRING; 1035309.A0A2C5WUY2; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000222788; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:PHH49520.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:PHH49520.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000222788}.
FT DOMAIN 10..140
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 328..546
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 557..619
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 620 AA; 68389 MW; A71FDBB2702FF30C CRC64;
MEGHVNTSSR LEALRKAMKE HDVDIYIVPS EDSHSSEYTA TCHARREFIS GFTGSAGCAI
ISLDKAVLST DGRYFNQASK QLDSNWTLLK QGIQDVPTWQ EWTAEEATGG KVVAVDPTLL
PTSIAKKLAE KVKKTSGTDL LPLRKNLVDV VWGDARPALP SSIIKALPER FAGKSVSAKL
ASLREELEKR KSAGIVISML DEIAWLFNLR GADISYCPIF FSYAIVTPDS AILYVDEARL
SADVRPGLEK SNVQVKAYDS FFLDCARLAP QPESGSDSVP SATPLNYLIC NKASWALKLA
LGGDKNVDEI RSPVGDAKAI KNPTELDGMR QCHIRDGAAL IGYFAWLEHE LTVKHSTIDE
VTAADKLEEF RKKQDMFVGL SFDTISSTGP NGAIIHYSPQ RNNCAVIDPN SIYLCDSGAQ
YLDGTTDTTR TLHFGVPSDF ERKAYTLVLK GNIALDMAIF PKGTSGFALD AMARQFLWKE
GLDYRHGTGH GVGSYLNVHE GPIGIGTRVQ YAEVALAPGN VISNEPGYYE DGSFGIRIEN
MVIVREIKTK HSFGDKPYLG FEHVTMVPYC RKLIDTGLLT EAEKSWINES HADIHEKMKE
RFENDPIALE WLKRETAPLV
//
