ID A0A2C5X8N9_9PEZI Unreviewed; 974 AA.
AC A0A2C5X8N9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=prp16 {ECO:0000313|EMBL:PHH54026.1};
GN ORFNames=CFIMG_000982RA {ECO:0000313|EMBL:PHH54026.1};
OS Ceratocystis fimbriata CBS 114723.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Ceratocystidaceae; Ceratocystis.
OX NCBI_TaxID=1035309 {ECO:0000313|EMBL:PHH54026.1, ECO:0000313|Proteomes:UP000222788};
RN [1] {ECO:0000313|EMBL:PHH54026.1, ECO:0000313|Proteomes:UP000222788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114723 {ECO:0000313|EMBL:PHH54026.1,
RC ECO:0000313|Proteomes:UP000222788};
RX PubMed=23931120; DOI=10.1016/j.funbio.2013.06.004;
RA Simpson M.C., Wilken P.M., Coetzee M.P., Wingfield M.J., Wingfield B.D.;
RT "Analysis of microsatellite markers in the genome of the plant pathogen
RT Ceratocystis fimbriata.";
RL Fungal Biol. 117:545-555(2013).
RN [2] {ECO:0000313|EMBL:PHH54026.1, ECO:0000313|Proteomes:UP000222788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114723 {ECO:0000313|EMBL:PHH54026.1,
RC ECO:0000313|Proteomes:UP000222788};
RX PubMed=24563841; DOI=10.5598/imafungus.2013.04.02.14;
RA Wilken P.M., Steenkamp E.T., Wingfield M.J., de Beer Z.W., Wingfield B.D.;
RT "IMA Genome-F 1: Ceratocystis fimbriata: Draft nuclear genome sequence for
RT the plant pathogen, Ceratocystis fimbriata.";
RL IMA Fungus 4:357-358(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH54026.1}.
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DR EMBL; APWK03000033; PHH54026.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5X8N9; -.
DR STRING; 1035309.A0A2C5X8N9; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000222788; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:PHH54026.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000222788}.
FT DOMAIN 286..449
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 474..646
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 110164 MW; 7FAE47246C4F299C CRC64;
MEESEYNGAM PKRRKLNNTR HNNADHDRLR NGPRGGRQQS YHDHQRTPSP PHENEEEERA
LDRDWYGGDE MGGHVFGDDS HNPFADYDSY ELQKTETAMA ERISGRYDAR KEQRQRENDA
WETNRMLVSG VAQRRDLASD FDDEETIRVH LLVHELRPPF LDGRTIFTKQ LEPVPAVRDY
QSDMAVFSRK GSKVVKEARQ QRERERQAQA ATSMAGTTLG TIMGVKDEDA DSALPMADEG
DGKTSNNNKF SQHLKKSDGA SNFSQTKTLR EQRQYLPAFA VREDLLRVIR ENQVIIVVGE
TGSGKTTQLA QFLNEDGYAS QGMIGCTQPR RVAAMSVAKR VAEEMECPLG GTVGYAIRFE
DCTSKDTVIK YMTDGVLLRE SLNEPDLDRY SCVIMDEAHE RALNTDILMG LFKKILQRRR
DIKLIVTSAT MNSKRFSDFF GGAPEFTIPG RTFPVDVLFH RSPVEDYVDQ AVNQVLSIHV
SMDAGDILVF MTGQEDIEIT CELIQKRLDA LNDPPKLSIL PIYSQMPADL QAKIFDKAAP
GVRKCIVATN IAETSLTVDG IKYVVDSGYS KMKVYNPKMG MDTLQITPIS QANASQRSGR
AGRTGPGKAF RLFTDKAFKD ELYMQTIPEI QRTNLSNTVL MLKSLGVKDL LDFDFMDPPP
QETITTSMFD LWALGALDNM GELTDIGCKM SAFPMDPSLS KLLITSVEYG CSEEMITIVS
MLSVPNVFYR PKERQDEADA QREKFWVHES DHLTYLQVYL AWQANRFSEG WCIKHFLHGK
SLRRAKEIRD QLTDILKMQK MPLSSCGMDW DIVRKCICSG YYHQAARYKG SGEYINLRTN
VAVQLHPTSS LYAGHPPDYV VYHELVLTSK VYVSTVTAVD PYWLADLGGV FYSIKEKGYS
AQQKKTTETE FNRRMEIEAQ MARDKKAAED KKLAEKLRVE KKTGADPSSG STKKVVQRGA
VRKPVAKKRF GRPL
//
