ID A0A2C5XT00_9HYPO Unreviewed; 459 AA.
AC A0A2C5XT00;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=GTP cyclohydrolase II domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDD81_5487 {ECO:0000313|EMBL:PHH58523.1};
OS Ophiocordyceps australis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1399860 {ECO:0000313|EMBL:PHH58523.1, ECO:0000313|Proteomes:UP000226192};
RN [1] {ECO:0000313|EMBL:PHH58523.1, ECO:0000313|Proteomes:UP000226192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map64 {ECO:0000313|EMBL:PHH58523.1,
RC ECO:0000313|Proteomes:UP000226192};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC {ECO:0000256|ARBA:ARBA00008131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH58523.1}.
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DR EMBL; NJET01000426; PHH58523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5XT00; -.
DR STRING; 1399860.A0A2C5XT00; -.
DR OrthoDB; 46806at2759; -.
DR Proteomes; UP000226192; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000226192}.
FT DOMAIN 93..248
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 289..414
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 38..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 50760 MW; 9CF07263E5A9328F CRC64;
MDQQQEISRN QLVGALDDIQ RSQTQLLAAI ESISERLIAS EPTARPVPHG AESEDGSSPM
GSMPTENEPT SLNKSSLLGS PRPLTASPSS KAGLSSRIVL TNFSGGSYSV YYALALASKE
LNLGHRPDFT NTEPAVQIGP FPQWAHRSKI IAMDPWGHIA PWIFSEIMEH EKIDIRPTIA
ITKAHMKLPE LEESVKNGRL VPDGKVCLNE LGELAVTKFA VEPVWYLPGV AERFGIDEGT
LRRSLFEHTG GSYPELITRS DIKVFLPPIG GLTVYCFGDP SKMSDSSVRL SLRIHDECNG
SDVFGSDICT CRPYLIFGIE EAVKEAQNGG SGVVIYFRKE GRALGEVTKR GADRASEYFT
RTENIAGVKD MRFQALMPDI LHWLGIKKID RMLSMSNMKY DAIVNQGIPI HERVELPQEM
IPADSRVEID AKITAGYFTT GKRLTSEELQ LVQGRIWEE
//
