ID A0A2C5Y0A4_9HYPO Unreviewed; 3569 AA.
AC A0A2C5Y0A4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDD81_1373 {ECO:0000313|EMBL:PHH60652.1};
OS Ophiocordyceps australis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1399860 {ECO:0000313|EMBL:PHH60652.1, ECO:0000313|Proteomes:UP000226192};
RN [1] {ECO:0000313|EMBL:PHH60652.1, ECO:0000313|Proteomes:UP000226192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map64 {ECO:0000313|EMBL:PHH60652.1,
RC ECO:0000313|Proteomes:UP000226192};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH60652.1}.
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DR EMBL; NJET01000135; PHH60652.1; -; Genomic_DNA.
DR STRING; 1399860.A0A2C5Y0A4; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000226192; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 4.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000226192}.
FT DOMAIN 2445..2962
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3214..3540
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3537..3569
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 165..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2970..3042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2981..3006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3019..3034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3569 AA; 407032 MW; 51FBB4BE91306A91 CRC64;
MSGTSLDDVV KRLSTSDLEA KDRLEAATSL RDSLDHYTSG QLYTVVLKRL MPVFINILRG
PCIYQSNSPE QKLRHCILEI LHRLPTAPAP TEPFEPYAQE TCELLMQLVR NDNEDNATLC
VKITSDIMRH QHKALQAKVQ DFLSLIQELF EQMPKVVREQ LDNAPSATLG QSGAPSTPGS
QQTNFQSPRP ASPVVSVPDL AADAQQQNRP LLRGMQSFKV LSECPIIVVS IFQIYRATVP
QNVKAFVPLI KNVLLLQANA QKQAHADAAA RGQTHTGVSS GIKNRAAFGE FITAQVKTMS
FLAYIMRQYS SHLNDFLPAL PNVIVRLLRD CPRDKSAARK ELLIAIRHII NYNFRKLFVP
IIDDLLDERT LTGDGLTVYE TMRPLAFSML ADLIHHVRDS LGPDQIRKTV EVYTKNLQDS
FPGTSFQTMS AKLLLNMAEC IAKLPNKVDA RHYHMLILNA IGDKFAAMNR QYPNAVKLSK
QYHQQAETGI SETYLADKEH PPDWDETDIF SAVPIKISNP RDRGADPVVD NKFLFRNLMN
GLKNTFYQLR ACNVAPPIDP QFAPSHWQDV SYGFTAEEVN IIIKLFREGA HVFRYYEIEK
PVSESQYSSP VEQMANFYMI SSSKEEKDLL ETFATVFHCI DPATFHEVFQ QEIPKLYEMI
FEHTALLHIP QFFLASEATS PSFCGMLLQF LMEHIDEVGS ADVRKSSILL RLFKLAFMAV
TLFAAQNEQV LLPHVVNIVT KSIELSTKAE EPINYFLLLR SLFRSIGGGK FEQLYKQILP
LLEMLLDVLN TLLMAARKPS ERDLYVELCL TVPARLSHLL PHLSFLMRPL VVALRAGTEL
VGQGLRTLEL CVDNLTADYL DPIMAPVIDE LMSALFSHLK PHPYSHFHAH TTMRILGKLG
GRNRKFMTAA VPLTYKEYSD DASSFDVRLV GSKWDRAFPA DLGIESAIQK LMEAPRTNKN
PQNRQHDDFY KKQSLHLIKS QLKLRIGYDQ LPDDLPRIVR LQAQDFISKK LDINFLPFET
SNRDKSIAKK DEQDQVTKNL LKAIMFAESI PDLGEEDDAF LVEICRHFTI IEIGRALVDI
KRTFNAFDPK AGEGPLFIDS RVLCDAIVES LASDHPDVRE AAKKAIREVH KTASIILGSE
LHVGRLPLFT HLSNTFCHSC YEEEWFTKSG GSLGINFMLT ELDFGDAWVA SKQTEFIRAL
MYVIKDMPQD LPEKTRRLAQ ETLEVLLRRI TRHIKKEDAM PIAQQPGQPP PKQTRLAQIC
MQFNSELAHM NKFVRETSKQ SLELIAKAAG CEVWELIDPY KERFLQPIYS KPLRALPFST
QIGYINAMTY HMSLKHDKVN LDENLNRLLM ESLALADAQD DSLANKPAEY RTHQHIVNLR
VSCIKLLSTA MTFEEFANSP TKPRILQVFF KCLYSESKPT IAAANDALKL VLAVDRRLPK
DLLQGGLRPV LASLSDPKRL TVHGLENLSR LLKLLNSYFK VEIGVRLLDQ IYSIVEPGAW
QQISFTFCEQ NPQMKVITAV LNIFHLLPSP AESFKERLIE NFLELEDKLR RTIQSPFRAP
IYLYLNRYPK EIWKHLVGKL HELKFGRLLA QVLSHPDSSP LREVAAEGVD ALVSRCNEVM
SEGGEKKFIA IVNSIHILDS ISQWHNACGW MNKKETISWL KTIGKELESH IRNYTLPADL
RLPAYQAAEQ LMTVLIKSLE RNPTDLDSLF SLIESITGGE LRATHALYHF LYEKIISNDS
IEFWKTTVLR CLDMYAGKMV SNKTKHFLLH YIVNPIVAMD VMRHWNSGDT NKGPRFLDRS
VIDAVSSKIW KVHPDEMTAE DATQPGIDHT RFEVLQLSAM LVKYYHTTIS DTRKDIIKFG
WTFIRLDDVI NKHAAYVVIG YFIAHYDTPP KIVNQVYLSL LKTNQNEGRA LVTQALELIA
PVLPKRCSSG PADRKGCNER GTAYAQPWAM APRRVLSDEG HNVQQMSSIF QFLVRHPELF
YDVRDNKKLA LNMMWLIWTK RKFEGMDQAT PTSPPAVRQT GSSERSEFQI SQMFRQKMMK
YLVEFIAQLN ERYQLPSARP REHNPSSVPQ TQPHYWGDLD IDLFPNVTDV ILCGEKTQTT
LNAEPSDKEK YDERFLTNII NTLQVVRIII NFKSDDWIQR NIAAVQKVLE KNIKYDDGRL
LKSIIQRVLD AVPEDAPMED ADAEGETEAQ TSSYISGVNL LWSLGKRKPA HYSALAAPAA
GELSAYDLEI QIKLMIKEIQ TVAVLATLVE KSMNIELCTE ILNMVEGWVF RSEGSWPTLK
EKTAFLDLVI RIYEDPKIAR TELTVRMEHA FLIGMRASDV DMRNRFMAIF DRSLSRTASA
SQFLLGAIIS ASQLAAVYPR DGKDLREASN MADDKFELLM AGHRRFVAEL GEHIDMTLAH
RLWRGMVALL TKDYHNRQMD KRPNVVQSLV EGAVKTPGCR LPPHVLKFLA KTFDVWYTAL
VHLEDAAVNP QKDSAPVRES NLNALVKLYA LLKEDDLFYG TWRRRCQFVE TNAGLSYEQN
GMWDRAQKLY ETAQIKARTG RLQQWEILQD LAKHENYQDL LLECAWRNMD MWQEAQHREA
CFMSLLKLHN QQETANDFAR VCDEAIQLSI RKWHQLPERL TNAHVPILQN FQQMVELHDA
SVICQSLANT NASNLDSKST ELKMLLAGWR ERLPNVWDDI TAWQDLVTWR QHIFNLINQT
YLQLLPPQNQ QNAAAGANSF AYRGYHETAW IINRFAHVAR KHSLPEVCIS QLSRIYTLPN
IEIQEAFLKL REQAKCHYES AEELSNGLDV INNTNLSYFN QQQKAEFFTL KGMFLEKLGQ
KSEADSSFGT ALYYDIGAAK AWAEWGYFND RKFKEDPTDL NAARQALTSY LQAAGSYKNG
KSRKLLARIL WLLSIDDDKG TIAMGFDDYK GETPVWYWIT FIPQLLTGLG HKEAPRVFNI
LLNIAKSYPQ ALYFQLRTSR EDMHIIKKNQ EAKERARQQQ AQQNRPDGSR AASRPGTANG
TASGAEATPA RSDGGDAGPQ SSRAGSQAQE QQPQGPGHKK HPWELTDEVM SVLKTAFPLL
ALSMETMVDQ IQKNFKCPPD EDAYRLIVAL LNDALTYVSR TPASFAKSVK LPSATETNIT
RFAENILPSH IKKSFEADFV KVKPTMYEYI HKLRRWRSKF EEKLDRRVRH APLESFSPHL
SEFRYQKFDE VEVPGQYLQH KDRNQDFIRI ERFLPNVDLV RSYSASYRRL KMRGHDGSVH
AWAVQHPAAR HCRREERVAQ LFRQLNQTLS RKKESRRRDL QFTLPLMVPL APHIRIVQED
TSYVTLQAVY EDHCRLVGLR KDEPVLFTLD KLRGVLESKN QLGKAELAPA ARLEVMKAVQ
AKWVPGTVAL EYFQQVFPQF AEFWLFRRQF SYQLAALSFM TYIVFMQNRN PFKMSISRAS
GNIWGSELIS FMSVTKPLFV SVEPVPFRLT PSLQVLMGPL ATEGIFGCSL MAIARCLTEP
QQELEHALTL FVRDEVICWM TSSHRNAISE NQLRESVQVN SDSILKRALS LAHNPSGNLP
ANQTVIDAIS KAVNPMNLAQ CDALWMPYL
//
