ID A0A2C5Y6M2_9HYPO Unreviewed; 666 AA.
AC A0A2C5Y6M2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=CDD81_3266 {ECO:0000313|EMBL:PHH65135.1};
OS Ophiocordyceps australis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1399860 {ECO:0000313|EMBL:PHH65135.1, ECO:0000313|Proteomes:UP000226192};
RN [1] {ECO:0000313|EMBL:PHH65135.1, ECO:0000313|Proteomes:UP000226192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map64 {ECO:0000313|EMBL:PHH65135.1,
RC ECO:0000313|Proteomes:UP000226192};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH65135.1}.
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DR EMBL; NJET01000021; PHH65135.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5Y6M2; -.
DR STRING; 1399860.A0A2C5Y6M2; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000226192; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000226192}.
FT DOMAIN 41..97
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 99..484
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 546..624
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 666 AA; 74040 MW; F71805215DEBACF5 CRC64;
MAGQPNGMRV YEAHEVDTFH PPEKMFAKHP SKPHLANLDE YRKLYKESIT DPAAFWGRNA
RELLSWYRDF ETVYSGSLAN GDSKWFVEGQ LNASYNCVDR HAFKDPERVA IIYEADEPGN
GRNVTYGELL RDVSKVAWTL KQMGVRKGDS VAIYLPMIPE ALVAILACVR IGAVHSVVFA
GFSADSLRDR VVDADSKVVI TTDEGKRGGK LIGTKKIVDD ALKQCPHVNH VLVYKRTGAD
VPMQRGRDLW WHEEVEKWPS YIAPEVMNSE DPLFLLYTSG STGKPKGVMH TTAGFLIGCA
MTGKYVFDIH DGDRYFCGGD VGWITGHSYV VYAPLLLGVS TVVFEGTPAY PNFSRYWEII
DQNKVTQFYV APTALRLLKR AGDEHVKSRM ADLRVLGSVG EPIAAEVWKW YFEVVGKEEA
HIVDTYWQTE TGSNVITPLA GVTPTKPGSA SFPFFGIEPA IIDPVSGQEL HGNDVDGVLA
FKQAWPSMAR TVYGAHKRYM DTYLNVYKGY YFTGDGAGRD HDGFYWIRGR VDDVVNVSGH
RLSTAEIEAA LIEHHAIAEA AVVGVSDELT GQAVNAFVAI KEGNEHDEAL QKEFIMQVRK
SIGPFAAPKA IYVVPDLPKT RSGKIMRRIL RKILAGEEDQ LGDTSTLSDP SVVDKILKTV
HESKRK
//
