ID A0A2C5Y788_9HYPO Unreviewed; 687 AA.
AC A0A2C5Y788;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Malic enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDD80_3477 {ECO:0000313|EMBL:PHH73918.1};
OS Ophiocordyceps camponoti-rufipedis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=2004952 {ECO:0000313|EMBL:PHH73918.1, ECO:0000313|Proteomes:UP000226431};
RN [1] {ECO:0000313|EMBL:PHH73918.1, ECO:0000313|Proteomes:UP000226431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map16 {ECO:0000313|EMBL:PHH73918.1,
RC ECO:0000313|Proteomes:UP000226431};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH73918.1}.
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DR EMBL; NJES01000309; PHH73918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5Y788; -.
DR STRING; 2004952.A0A2C5Y788; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000226431; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR PANTHER; PTHR23406:SF32; NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000226431}.
FT DOMAIN 186..366
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 376..643
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 76241 MW; 1C1B7BC247E8AE4C CRC64;
MPAPSRTDSF DEVSTPVSSS STSSIVSVRS SNTVLSSKRM SLSSRRLTDS NPLSSVNMDD
IADSLRSTTA LDHHRGYVQN HFSEVKQARD TDYVPHDRAA GYQVLREPQW NKGMLPFPLT
RRLVSLANSV VMKGLSFSPE ERMSRNLTGL LPHAMESLET QCARAMKMIN TRQTNIDKYL
YLSTIKGQNT DLFYRLLMDN LRDLMPLVYT PTIGDVCLQY STIYTRPEAL YVSYKQRKSI
RTMLRNWPYP NPEICVVTDG SRILGLGDLG VNGVGISIGK LALYTAAAGI HPDKTLPIVL
DCGTDNEANL KDPLYLGLRQ RRVSRPAQQE FMDDFMEAVQ DVYPDMVVQF EDFDSEKAFN
YLDRYRNSHK CFNDDIQGTG AVVLAGYIGA VNLSGVPVDE QRLVFMGAGS AGVGVAKQLV
EYYTRRGLTE AEARDKFWLV DTKGLVTRDR GDALAEHKKY FARTDNQGQQ FRTLEEVIEY
VKPSALVGLT ATFGVFTDSV VRALKASVDG GGLGRRPILF PLSNPLTKAE CTFEQAVQWT
DGSVIFASGS PFHSFTVKVG GEVGNVTYHP NQGNNVYVFP GLGLGAILAK ATRVTDNMVY
TSAEALAGTL NSEEAQRGLI YPRIERVREA SVVVAREVMK AARRDGVSGL SDAMWNEWEE
WGDVALTAYI KRRIYDPVCF ADAKPLL
//
