ID A0A2C5YY02_9HYPO Unreviewed; 1509 AA.
AC A0A2C5YY02;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=CDD80_3661 {ECO:0000313|EMBL:PHH73637.1};
OS Ophiocordyceps camponoti-rufipedis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=2004952 {ECO:0000313|EMBL:PHH73637.1, ECO:0000313|Proteomes:UP000226431};
RN [1] {ECO:0000313|EMBL:PHH73637.1, ECO:0000313|Proteomes:UP000226431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map16 {ECO:0000313|EMBL:PHH73637.1,
RC ECO:0000313|Proteomes:UP000226431};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH73637.1}.
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DR EMBL; NJES01000328; PHH73637.1; -; Genomic_DNA.
DR STRING; 2004952.A0A2C5YY02; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000226431; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000226431};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1509
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013219921"
FT TRANSMEM 1379..1400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1430..1451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..693
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 739..1368
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 659..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1509 AA; 168689 MW; AA14BFF1C9EACFA7 CRC64;
MRLRGSAPWR ILLASLFWTA LAIAKDAPDL TVNKFNHPPL SLHYFEDSDV VVFHDVEERN
VYRSKDAGVS WSRVDAVPEG KSVALVMHAS DPKSAFVLTA SGSHYKTDNR GDGWREFKTK
SMPSKFQPEI LIFHADDPNR IIFNGMDCEG IFCDEQALYT TDGFKSVKLL RSFTVGCWWA
RSSKAFTTGD AELDKSRVLC VVKDPFSFFR QDQRLLVSDS YFAVAGNTIQ EFEPNVDGDK
GASGVMNYAA VNKFVLVATA SARSDEMALF VTGDTIKWHR AMFPTDGTHD HSHRIHQEAY
TVLEGTNYSI QIDVMTSRPS NPMGVLFTSN SNGTMFTENI AFTNRNIKGH VDFEKISGIQ
GIFLVNVVDN GDDVSKKSVK KDVVTKITFD DGRTFDKIKV GDETLHLHSV TELDNVGRVF
SSPAPGLVMG NGNVGKSLTK LSEANLYVSD DAGLTWRKAL DGPHKFEFGD SGSVLVAIKD
SEKEDVKDFS YSLDHGQNWK SVPLPNDLSI KPGLLTTTQD STSLKFLLMG RSKKTYHLVA
INFDGLHERT CGEDDMEDWH ARVDKEGKPT CVMGHKQTYR RRKKSADCFI KNEFKDPVPK
SEDCECADVD FECDYNFQRD PDDKTKCKKA GPIPVPEGEC KDKAGGTFKG SSGWRLIPGN
TCKRTSGPQK DDKVDRDCSD SVTAPKPPAS DKVTSKQFVF DSKLKDFEKM YLERSDASSS
TDETIIVRPA EYEGSGRMKV ENRLWISHDH GKVWERILKG EDVEGVYPHQ YFKDVVFFTT
TGDKVLYTVD RGQSFHPIKA PTKPSSGEAN LSFHPDKKDW LIWLGEKCET VGDKKSCHNE
ASLSTDRGDN WRTIERYVER CEFTGNSAYN FRETKQIICL VRKGEKKDGP MSLVSSNDFF
FEDKMTLEHE AINFATMSEF IVLAAKDEKT KDMLALASLD GKHFDKAHYP HNFRKGHQNQ
YTLLDSSTHA INLFVRTEGG ADRQYGSVIK SNSNGTSYVL SATDVNCNQE TYVDFEKVAG
LEGVVLINVV TNTDKKERKK VLQTKISHND GSEWGYLAPP AKDADGKAYQ CSSSKGDGSC
ALHLHHFTER DDRRRTFAAD TAVGLLFGIG NVGSSLGDVK DADTFLSTDG GMTWTCVKKG
EWTWQYGDQG SIIVLVQRAT RANPVQTKMV SYSLDEGRTW ADHQFSDSEV TVLDITTLKS
GTSRNFLVWC KSKDKAFSVN LDFSGLASKA CKFDKDAPSD SDYYLWSPKH PLQDDDCLFG
HVARYLRKKT DRKCYNDQSL HRLFDHKNCA CSRRDYECAY NYELDQHGQC ALVAGLKPLS
GDEWCAKHPN ETSWFEPTGY RKVPLSTCQG GNELDKTSTE HPCVGHEEDF DKKHRTSGAV
IFLAVTIPFA LAGAIGWYVY RNWDGKLGQI RLGEQTSTFD SDRLWIKYPV IAVSALAALA
AALPLILAGL WRSATGTYGR VRGDGRDAWF SPGTTRPFTT RDSFARGRGD YAMVDDEGEL
LGQDSDEDV
//