ID A0A2C5YZQ3_9HYPO Unreviewed; 1091 AA.
AC A0A2C5YZQ3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent RNA helicase DOB1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDD80_4111 {ECO:0000313|EMBL:PHH72990.1};
OS Ophiocordyceps camponoti-rufipedis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=2004952 {ECO:0000313|EMBL:PHH72990.1, ECO:0000313|Proteomes:UP000226431};
RN [1] {ECO:0000313|EMBL:PHH72990.1, ECO:0000313|Proteomes:UP000226431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Map16 {ECO:0000313|EMBL:PHH72990.1,
RC ECO:0000313|Proteomes:UP000226431};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH72990.1}.
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DR EMBL; NJES01000377; PHH72990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5YZQ3; -.
DR STRING; 2004952.A0A2C5YZQ3; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000226431; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000226431}.
FT DOMAIN 166..322
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 402..606
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 123099 MW; 4995FFEE603CDE42 CRC64;
MDEMFDVFEG KAGPQSDSDG ERAKSRDKSK KRKADEAING AAASSSAPRE TVDVEMGDAT
ESSNDDDSDE ESDTPSQQDK KRRKKEDGVG PVMTDAFKTE QSREVAAAKT LLPQDASLVL
SHNIQHQVAL PPDLDYEYVP LSEHKSPDEP ARTWSFKLDP FQSLSVASIE RDESVLVSAH
TSAGKTVVAE YAIAQCLKRN QRVIYTSPIK ALSNQKFRDF DGIFGDVGLM TGDVTINPTA
SCLVMTTEIL RSMLYRGSEI MREVAWVVFD EIHYMRDKTR GVVWEETIIL LPDKVRYVFL
SATIPNAFQF AEWIAKIHHQ ACHVVYTDFR PTPLQNYFYP TGGKGARIVV DEKGIFNEKN
FNSVMEEVEE LKGSASADPN ARMKGKGKNK KINKGGADPG SPIYKIIKMT IKNNFNPVIV
FNFSKRECED IAKKLSGLDF NDDSEKAMVR KVFESAIEQL SEQDRELPTL QYILPLLEKG
IGVHHSGLLP LLKETIEILF QESLIKVLVA TETFSIGLNM PAKTVVFTQV TKWDGTAVRA
ITSSEYVQMS GRAGRRGIDA RGIVLMMVDD KLEPSVAKQI VTGQQDKLNS AFHLGYNMIL
NLLRIEAISP EYMLEKCFHQ FQNAASVPTL EKDLMALQQE RDDMSIPDEA TIKDYYQIRQ
QLNTFTRDMR AVIQHPQYSL DFLQPGRLVQ IYNPKQSPDN VGGGVDFGWG VILNHSPRKG
PRMGEPQYSA QESYMIEVLL PISASSKEIG PSQPAGEMPP GLSPATSEQD TIHEVVPCLL
SCVKAISQIR IFMPKDGLKA GEDKEQAYKS LTEVKRRFPD GVPILDPIEN MDIADESFKK
LMRKIEVLES RLLANPLHMS PLLPSLWDQY HNKMQIAEKI KEKKKTMAKA HSISQLEELK
SRKRVLRRLG FINDSEVVQL KARVACEISS TEGHELLLSE LLFDRFFNEL PPDKCAAVLS
CFVCEEKLET QALKEELQKP FREIQAKARI VAKVAQEAKL DMNPEEYALS FKWQLMETVY
RWAQGRSFLE ISKMTKMYEG SLIRVFRRLE ELLRQMAQAA KVMGNDDLVK KFEECLQKVR
RDIVAAQSLF L
//
