ID   A0A2C5Z7J9_9HYPO        Unreviewed;       525 AA.
AC   A0A2C5Z7J9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CDD80_1907 {ECO:0000313|EMBL:PHH75976.1};
OS   Ophiocordyceps camponoti-rufipedis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=2004952 {ECO:0000313|EMBL:PHH75976.1, ECO:0000313|Proteomes:UP000226431};
RN   [1] {ECO:0000313|EMBL:PHH75976.1, ECO:0000313|Proteomes:UP000226431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Map16 {ECO:0000313|EMBL:PHH75976.1,
RC   ECO:0000313|Proteomes:UP000226431};
RA   De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT   "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT   behavioral manipulation genes and a possible major role for enterotoxins.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHH75976.1}.
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DR   EMBL; NJES01000186; PHH75976.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C5Z7J9; -.
DR   STRING; 2004952.A0A2C5Z7J9; -.
DR   OrthoDB; 380531at2759; -.
DR   Proteomes; UP000226431; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000226431};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          143..216
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000259|Pfam:PF05922"
FT   DOMAIN          255..478
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          35..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        264
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        302
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        441
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   525 AA;  56725 MW;  C433CA9D2EED82E9 CRC64;
     MAEIPGRFDA RKNVVSVIFN ANKDVVRLVR SSFFTSNTSQ HSPAYDPASA THTGSPSGGG
     PQNANAGSTS RGGPQNANAG SPSQGGKQSV PATRPLSNAA ANKGRPQVWQ QVHKAQFTGG
     QDDEEQSTDG QDDESCDISR LGYIVVFKPG VSEDEIEDHY RWVAEDLVPD FELDEESVFN
     LDDFNAYVGY FDNSTADTIR SESVIESIEK DTRVQIQSND HVQRSKLPVP WGILSLTKPK
     AERPSGAEEA KLGTGEGSHV YVLDTGINAK HIEFGGRVSR GHCLSCNLWQ RINKSWKDTE
     GHGTAVASVV AGTTVGVAKK TNIIDVKVTC GGSLNGLTLA NGLKWIVADV KKNKRQKRSV
     VHMSLGVLVV SSAGNEGIPS QWRSPLSKPG VIIVGAYRDS TRRELATSNY GRGVDILAPG
     FGILSADVED DSDYIKETGT SFSAPFVSGL ALTLIASRNF TVSPEEVKDM ILNTAQKDVT
     VLETGEEGLG KGIPRSNEDD IGLTPARRLW FNPYYDWRDM ESPRL
//