ID A0A2C5ZT09_9HYPO Unreviewed; 437 AA.
AC A0A2C5ZT09;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=MHD domain-containing protein {ECO:0000259|PROSITE:PS51072};
GN ORFNames=CDD83_3418 {ECO:0000313|EMBL:PHH92928.1};
OS Cordyceps sp. RAO-2017.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=2004951 {ECO:0000313|EMBL:PHH92928.1, ECO:0000313|Proteomes:UP000221130};
RN [1] {ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|Proteomes:UP000221130};
RA de Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PHH92928.1, ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|EMBL:PHH92928.1,
RC ECO:0000313|Proteomes:UP000221130};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|PIRNR:PIRNR005992}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH92928.1}.
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DR EMBL; NJEV01000019; PHH92928.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C5ZT09; -.
DR STRING; 2004951.A0A2C5ZT09; -.
DR OrthoDB; 6959at2759; -.
DR Proteomes; UP000221130; Unassembled WGS sequence.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd09251; AP-2_Mu2_Cterm; 1.
DR CDD; cd14836; AP2_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR043532; AP2_Mu_N.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR043512; Mu2_C.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF236; AP-2 COMPLEX SUBUNIT MU; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Protein transport {ECO:0000256|PIRNR:PIRNR005992};
KW Reference proteome {ECO:0000313|Proteomes:UP000221130};
KW Transport {ECO:0000256|PIRNR:PIRNR005992}.
FT DOMAIN 168..436
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
SQ SEQUENCE 437 AA; 49244 MW; A75A4E0644226099 CRC64;
MISGVLIFNQ KGENLIFRAF RNDCRPRLAD VFRIQVISNA QVRSPILTLG STTFSHVKHE
NIYLVAITKS NANAALVFEF LYRLIQLGKG YFGKFDEEAV KNNFVLVYEL LDEIIDFGYP
QNTETDTLKM YITTEGVKSE ARPEDTSKIT MQATGALSWR KADVRYRKNE AFVDVIEDVN
LLMSATGAVL RADVTGQIVM RAYLSGTPEC KFGLNDRLLL DNDGLQSYPS GNRTGTKATK
AAAGSVTLED CQFHQCVKLG KFDSDRIISF VPPDGEFELM RYRATENVNL PFKVHAIVNE
VGRTKVEYSI GVKANFGPKL FATNVVVRIP TPLNTAKITE RCTQGKAKYE PSENNIVWKI
GRFTGQSEYV LSAEAILTSM TNQRAWSRPP LSLNFSLLMF TSSGLLVRYL KVFEKSNYSS
VKWVRYMTRA GSYEIRF
//
