ID A0A2C6A6J8_9HYPO Unreviewed; 1698 AA.
AC A0A2C6A6J8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CDD83_8537 {ECO:0000313|EMBL:PHH87680.1};
OS Cordyceps sp. RAO-2017.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=2004951 {ECO:0000313|EMBL:PHH87680.1, ECO:0000313|Proteomes:UP000221130};
RN [1] {ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|Proteomes:UP000221130};
RA de Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PHH87680.1, ECO:0000313|Proteomes:UP000221130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1346 {ECO:0000313|EMBL:PHH87680.1,
RC ECO:0000313|Proteomes:UP000221130};
RA De Bekker C., Evans H.C., Brachmann A., Hughes D.P.;
RT "Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential
RT behavioral manipulation genes and a possible major role for enterotoxins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHH87680.1}.
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DR EMBL; NJEV01000566; PHH87680.1; -; Genomic_DNA.
DR STRING; 2004951.A0A2C6A6J8; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000221130; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22705; FHA_KIF1; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000221130}.
FT DOMAIN 1..326
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1524..1678
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 591..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1578..1611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..795
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1425..1441
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 73..80
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1698 AA; 187917 MW; C5E4E5B698BC5E1A CRC64;
MKDNQTVLTP PDGQGGRAVK DNAAKTFAFD RSYWSFNKED SSYAGQSNLF DDLGKPLLDN
AFQGYNNCIF AYGQTGSGKS YSMMGYGKEV GIIPNICQEM FRRIQSIQDE DKNTKCTVEV
SYLEIYNERV RDLLNPATKG NLKVREHPST GPYVEDLAKL VVGSFQEIEN LMDEGNKART
VAATNMNETS SRSHAVFTLM LTQKKHDAET KMEMEKVAKI SLVDLAGSER ATSTGATGAR
LKEGAEINRS LSTLGRVIAA LAELSTGKKK KGSGQVPYRD SVLTWLLKDS LGGNSMTAMI
AAISPADINY DETLSTLRYA DSAKRIKNHA VINEDANARM IRELKEELAL LRSKLGGGGA
TSPGGAALPP DEVYDEGTPL EQQMVTITGS DGAVKKVSKA DIAEQLSQSE KLLTDLNQTW
EQKLQKTEEI HKEREAALEE LGISIEKGFI GLHTPKKMPH LVNLSDDPLL AECLVYNLKP
GTTTVGNVDT NADHQANIRL NGTRILHDHC TFENAADGTV TVIPSEGASV MVNGKRIAGP
KQLHSGYRVI LGDFHIFRFN HPMEARAERA EVGQSLLRQS VTASQIQALE RTSPCPSPRP
GHDRSVSKTS DFLESPRPES PAPFARNGRD SDWSLARREA AGAILGSDQN FASLTDEELN
ALFEDVQRAR AERVNVREDG EDSESVTSYQ LREKYMSTGT IDNFSLDTAL TMPSTPKQGE
AEDRLREARE EMQNQLERQK EEFQEQLKSA EASNVEVEEI RIEKAKMETA LQELKDDMQK
QLNLQRQQFE EKMEKLDPLK RPRPNPKLSD AEVERARAIL KVWRGRYFVK MAESVLQNAA
ILKEAQIMSN ELNENVVFQF TVVDVGHVLC SSYDMVLNGL TGEGEDPALE EARKPCIGVR
VMDYKNSVVH LWSIEKLQDR VRQMRQMHQY LDQPEYAQHL SLDNPFVETC MPSYTLVGEV
DVPLKAVFES RVQDFSLDVL SPYTSHAIGI VKLSLEPSHA RAPSNTLKFN VVMRELIGFA
EREGAEVHAQ LFIPGQSEED GVTTTQMIQD FDEGPIRFES VHNMSVPLFA PQDVTLRVAI
FARVSSMHLD KLLSWDDMRD AAPARDGSRA TRINESQFYT QEKHDLLSRV QIMELNENGD
YQPVEVTQTS ELDTGTFQLH QGLQRRIVVN ISHSSGDALP WGDITAVRVG KIRLVDSAGK
TPDMGSNGPD VSLKLSSSPV FRENANGTRS ITLFAQWDSS LHNSLLLDRV TADKYRVQMT
INWEIGSEKL AEPMKFAQKV CVQILSRTFV RQTSMFSSLF QNMRFVRSST GIFTLTMRPA
PIKRVGDLWR MNSRHDYVKG EENLASWAPR GVSLVSDFIL ARKKRRRAAD IGVTQATLNK
LGLAGAGPAR SKDGGPEAEG PAGVRAIVQD DDDDLLNDTP DTSQAPSLDD EEGEGEGDKA
EEQADESTIR VDEQGAAASE REAYGEHEAE LLRKCLQLWT KYPDPLSSIL GPANTAPPQN
GIATESPLPP SLITTIVRVP KNPKVLKGGY LLVPNSDSTR WIKRFVELRR PYLHIHSASD
GDEVALVSLR NSRVDSQPGV LGLLHGPDDS QEGGPRGDNG AGDFTPGHRR TSSGRVISTI
WTGTGGSPSS GGQGLQRLSE RLQSAVFAVY GTDNTWLFAA RSERDKMDWI FRIDQTYLSN
SESTPNSGIM SPFSGSQN
//
