ID A0A2C6CSI4_9BACT Unreviewed; 506 AA.
AC A0A2C6CSI4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=CEQ90_04530 {ECO:0000313|EMBL:PHI20958.1};
OS Lewinellaceae bacterium SD302.
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae.
OX NCBI_TaxID=2014804 {ECO:0000313|EMBL:PHI20958.1, ECO:0000313|Proteomes:UP000223945};
RN [1] {ECO:0000313|EMBL:PHI20958.1, ECO:0000313|Proteomes:UP000223945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD302 {ECO:0000313|EMBL:PHI20958.1,
RC ECO:0000313|Proteomes:UP000223945};
RA Wang K.;
RT "The draft genome sequence of Lewinellaceae bacterium SD302.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHI20958.1}.
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DR EMBL; PDLQ01000005; PHI20958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C6CSI4; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000223945; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PHI20958.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000223945};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..149
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 157..468
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 506 AA; 57314 MW; B6345E97829AFE75 CRC64;
MITGTLKSQV DQIWNHFANG GLTNALTVIE QFTYLLFLRR LDERQLRQEK QASILGEPPE
NPIYPPEERP LRWNVFSNFG PDRLFEVFTR GVDVRTEAEK AKPGSEPRYL TAFDKMKEVG
RAGGVFSQHM KGATFMIGKP RLLDQVVTEI GKIEMADRDT KGDLYEYMLS KIASAGRNGQ
FRTPRHIIRS MVRMMQPDRL DTICDPSCGT AGFLVSAGEY LHDEKPEWFN DKTFRDHFNN
RMFNGVEIDP SMLRIGAMNL QLHGIEAPNL LERDALSERN ADQRDLYSLI LANPPFKGSL
DYDAVESSLL DTAKTKKTEL LFLSLMLRML ATGGRAAVIV PDGVLFGSSK AHKAIRAELI
EKHKLSAVVS LPGGVFKPYA GVSTAILIFT KTGTGGTDQV WFYDLQADGF SLDDKRQSTT
ENDLPDLENR FHALAAETDR ARTDQSFLVP KQEIVDNDYD LSINRYKEIV YEPVDYDPPA
VIIQRLKELE QERFEVLEEL EKMMGE
//
