ID A0A2C6DSP2_9GAMM Unreviewed; 655 AA.
AC A0A2C6DSP2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MacB family efflux pump subunit {ECO:0000313|EMBL:PHI31834.1};
GN ORFNames=CRN84_22200 {ECO:0000313|EMBL:PHI31834.1};
OS Budvicia aquatica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Budviciaceae; Budvicia.
OX NCBI_TaxID=82979 {ECO:0000313|EMBL:PHI31834.1, ECO:0000313|Proteomes:UP000224974};
RN [1] {ECO:0000313|Proteomes:UP000224974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_387 {ECO:0000313|Proteomes:UP000224974};
RA Minogue T., Wolcott M., Wasieloski L., Aguilar W., Moore D., Tallon L.,
RA Sadzewicz L., Ott S., Zhao X., Nagaraj S., Vavikolanu K., Aluvathingal J.,
RA Nadendla S., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC exporter (TC 3.A.1.122) family. {ECO:0000256|ARBA:ARBA00038388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHI31834.1}.
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DR EMBL; PDDX01000001; PHI31834.1; -; Genomic_DNA.
DR RefSeq; WP_029096752.1; NZ_PDDX01000001.1.
DR AlphaFoldDB; A0A2C6DSP2; -.
DR STRING; 1111728.GCA_000427805_03229; -.
DR OrthoDB; 9770036at2; -.
DR Proteomes; UP000224974; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB-like_ATP-bd.
DR InterPro; IPR025857; MacB_PCD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR30572:SF14; MACROLIDE EXPORT ATP-BINDING_PERMEASE PROTEIN MACB; 1.
DR PANTHER; PTHR30572; MEMBRANE COMPONENT OF TRANSPORTER-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000224974};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..244
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 226..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 70722 MW; F516BC54D46D8356 CRC64;
MAQPLLQLDN ITRQFPAGEQ TVTVLKGINL TINAGEMVAI VGASGSGKST LMNILGCLDK
PSGGTYKIAG RATNQLMPDD LAELRREHFG FIFQRYHLLG DLTAAGNVEV PAIYAGTERQ
KRKDRAVALL TRLGLSDRTS YRPSQLSGGQ QQRVSIARAL MNGGQIILAD EPTGALDKHS
GQEVLKILKD LHGQGHTVVI VTHDMQIAEH AERIIEISDG NIIADRQSRP DQETTTPAKG
IPGSSHHTKT NNGFSAQRDR FVDAFKMALL AMVSQRLRTF LTMLGIIIGI ASVVSVVALG
EGSRQKILAD ISSMGTSTLE VFPGNDFGDR KASTIHTLRA SDADALRQQG YVHSVTPSVS
TSTTFRVNNQ SVTGTVNGVG EQFFDVRGYK LAQGMSFNLN SVNSLSQDAV IDENTRNKLF
GEQSNPVGQV ILLGNLPARI IGVVEKQQSG FGSNESLNVW LPYTTVMNRM LGQSYLKSIT
VRINDNVDLN VAEQGVTKLL TQRHGKQDFF ILNTDSIRQT IEKTTATMTL LVSMIAVISL
IVGGIGVMNI MLVSVTERTR EIGVRMAVGA RSSDIMQQFL IEAVLVCLLG GTLGVGLALA
IGSLFDQLVS SFSMIYSVTS IVAAFACSTL IGVIFGFFPA RRAARMDPIN ALERE
//
