ID A0A2C6JN67_9APIC Unreviewed; 1351 AA.
AC A0A2C6JN67;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sodium:neurotransmitter symporter family protein {ECO:0000313|EMBL:PHJ17691.1};
GN ORFNames=CSUI_008484 {ECO:0000313|EMBL:PHJ17691.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ17691.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ17691.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ17691.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ17691.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MIGC01004749; PHJ17691.1; -; Genomic_DNA.
DR VEuPathDB; ToxoDB:CSUI_008484; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF279; SODIUM-DEPENDENT SEROTONIN TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 3.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000221165};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 447..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 960..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1200..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1252..1279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1351 AA; 148053 MW; 0B0FF88B5760418A CRC64;
MLGGKPSSSS SSFQAEEGER VVEDQGRQTE EEEEEEHGRD EGFSSSSGRP VRAREEEKRR
DEEASSSNSR KIEMQRIVPS SLIREGSLSS VTTPSRDDRR GVHTPYHLSA YPVVSSSPTS
ASSHVASSPA SFSYSPSLHR LHTPTSSSHL LPPFSHVPSP HNGGGVYTPG TPHTTQPVEV
LIDNCAYRQQ DFFLSPSSFS RPDDPFFPHD QLENPDTCPV CTPVSPILSP RLVRVASPSS
CGQKQDVMSL CRKDSLPPVN RMNYYNSRHL LHSDKARGSA SGGACSHLCS SPHAYRGWFP
SSFRTPGVNR SSSPPSSSRR HPHLHYGTDR RRDSLRGHEE DSTETSSASF PSLLCPCFKS
SRHGRGISRR RRSSPLSEED DGKPSSSSHR HRQHREEDSY LSSSSSSCHV EWDNRLTFVI
ATIGAAVGIG CVWRFPTYCY KFGGGIFLVP YLLMLFILGI PIHTLEMSLG QVFRGGQMKV
LNLISPRLRG LACATILQAF FICSYYSVFL AWGFQYLLSS FHANLPWTVT QDQVDLCSSA
HDQEACYHSQ VSPSVDRDKK HLSPSLSSFS SSSSSSCVWI RPRTLLGEEA RDGGGGVCVA
DIRGKAKEYF FQDILGLSFF SESSSGDVVP KGEIGLSGYV VLGLFIVWIQ IYFSLFKGLQ
SLTVMVYAAV LLPIASMIFV TISSLTLDGS SSGLRYLFLF DWATLIERPE IWGEAASQVF
FSLGVFQGVM AAYASHKKKL TQNTLVDTLI VSGTNTLLSF ISGVCTFSIA GHVAKKLGSI
DAETGLADLS SINLGGSELV FILYPISLSA LPFLPQVFCL LFFISFCLLG ITSAISFVQP
VIGFLTESKA LASSSSSSCS PSSSLSSLSS LSSSSSSLAS SSSSRRRSRS RWMKVTFIVS
CIGFLLGIPF CMKTGIYLID TADYQWSVVG ITFIGTCECI AFGWIYGLNR QVQCLGGSYL
PVYLYAISYL GGIFLAAILL FVVPSSAIAS FQLMSYRTYI ILSILLSVSL VLTGAAVALY
LTPSVVYQKT LMGRSHATSP SAQPGNSSLS QREEEGGGGQ LGIPEEGKRK DQEEEEEKER
REDSQEKKKT ENGHCSSFSC KENGDDDDKS TVVSYQHPLP SSSHEENRSS SSLSPSSLSS
THPNKTSSSH LSLPPRSSPP SLFYTEAKIP LKTRLYWLYI GNIEHLRLNL NAITASNSKF
LYLWPVWSLI IKYLSPLVLT FLLFHELGRG AGGTAAASPQ ASRYVSTETS RLAYQASAGA
VLLLILFIVA LGIAFPQLFD GLVASERKLE PRMIVIGTGK GEGKEKDEKK TTEKKTERKE
DEERRTEKEH EKEEKDKKEE EQGDVKAVMF T
//
