ID A0A2C6KEY0_9APIC Unreviewed; 5563 AA.
AC A0A2C6KEY0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Type i fatty acid synthase {ECO:0000313|EMBL:PHJ15679.1};
DE Flags: Fragment;
GN ORFNames=CSUI_010510 {ECO:0000313|EMBL:PHJ15679.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ15679.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ15679.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ15679.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ15679.1}.
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DR EMBL; MIGC01007632; PHJ15679.1; -; Genomic_DNA.
DR VEuPathDB; ToxoDB:CSUI_010510; -.
DR OrthoDB; 5491581at2759; -.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 3.
DR CDD; cd08955; KR_2_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 9.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08240; ADH_N; 3.
DR Pfam; PF00107; ADH_zinc_N; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00829; PKS_ER; 3.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF50129; GroES-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 9.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000221165};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..203
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1824..1900
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1923..2349
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3976..4052
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4080..4500
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 693..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3257..3287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3672..3692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4915..4935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3675..3689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PHJ15679.1"
FT NON_TER 5563
FT /evidence="ECO:0000313|EMBL:PHJ15679.1"
SQ SEQUENCE 5563 AA; 603888 MW; 35CCB051621F17E0 CRC64;
TFDASANGYV RGEGLGSLVL KRVSQAAKDD DRTLCVVRGT AVNHGGRSAS LTAPSGPSQQ
RVIRTALRQA GVTPGDIYFI ETHGTGTSLG DPIEVGALKA VFAASRDAKT KPLILGAVKT
NIGHLEGAAG IAGALKAMLA LRYKQIPPNL HFKQMNPHID VKEFPVVIPL SGIPYPRCED
KPLFAAVSSF GFGGANGHIV LQEAPQPIGI KQPCKRHMRN VVCFMFTGEG YEVSCMGKYL
YDTDQVFKEI INKCNDILKR WLNVPLLSIL YPPPEKKEET DKTMHQARFG HSALFAFEYA
LAEYMVSKGV KPDVVVGVGL GELVAATFAG VMSLEEALYV VTQRAKLVDN LLPLEGVMAA
CRVSEQEVEM ALSEMEINSR KSVSVAVVYG RKNLILSGEQ SEIDNVLMKL NIAGRWKYLP
VHNVLTANRV GDLVAPITHV MSTVKLCRPK LRLVSSTTGE FVDKEALAGR YWARQVTQTV
QLQQAIGNIV ASGCSLFVEI GPQTVLTKLA QQSLNGNAKD VTWVPAYEAD SEKAEFFEEA
IKNSSEAIKL IGKERSLEEG LYGHEELIFH RKPFPWTEIP HPFLGAHKFT GKDEIIFETA
FPRRAIPLIA DHAVNGTVMM PGAGMVEMIA AAALAVDLRT TSGAVALENV SFERPMLVGE
PRVTYEYNKR KPSGDGILGS PRIVRTPRRV NDAYLRTPRA VDKTDGGSGA EAHRPSFGGE
GQQSSGQQQG KLGVLEDIKD YAQTMLRRAV QHSIDDSGVA TVSDTVTGPR HPREGTPSRG
TGYPSESLTV PLGVGMTVRC RVTKMKEVEL STVWDEEQTT HCFATIVIKE KQQEALEPLR
AVLERCPSYM DVAEFYDTLF DAGLQYGLRF RTIQDLYKGE KEAVARLQVV GNVKHDPFES
GFLIHPAVLD GAFQAAACLL DHAHNSNKVM VPVSVGEASL TKVEICQPCW AHVQLIENRT
KVARFHVTLY EETTQEVVAS IRSLTVRQVD PSANVVATIP KELLWKVNWQ LLEGGSEEIA
SQAPVLFIGG NLELTEALEN AMSGGCKILT VDALPRERAE LQKVLSAEQW KSVVYVEAVT
AGVYDALDVM SVALRIVQAH FINLNSGKAV GALWFVTRDS VLLDVGNKPS ADIPAHAGLW
GLAKAAKLEL EVSAGSPVSL GCFDVSAADV PSMAQQIVSA LKSKALNCNE SEVAIRESGT
YAARLMPSHE VAVKGAIELH MPERGAISNL VLRPQAFASR VPPEEGQVEV RIRAVGLNFR
DVLNVMGLYP GDPGPPGADC AGIVVAVGDN VQHIEVGDCV FGIAQGCLRT YVTTDCRLLR
KMPESLTFEQ SAALPVVVAT VEYALHDLAK VKAGDKVLVH AVSGGVGLAA IQYCKRVGAT
VYGTCSGGKK AAFVKSLGVQ CISSSRDAKA FADDMRGFLG EDGKFDVVLN SLVDDFIPES
LKLLGPYGRF IELGKRGIWT KEQMTAERPD VQYETIAVDV MMEEDPVWFG GMLDRIRMLV
ATQKLEPLPL HVYDMSDVGE NGGVAAFRFM QRAQHTGKVV LKIPSPITDA SKGAIVVTGG
LGALGLVVAG WLAEEGARHI CLLSRRPAAP EPGEVPGWDW LKSINCQVEF FSCDMSKYEN
VKSVFKAIQA NVAPVQGIIH AAGSLADALL DSQTPEVMKK VYSGKVQGAW NLHRACEEMG
LNDQLNFFVL FSSVTSLLGN FGQANYCSAN ACLDALAAWR RARGLCCQSI QWGPWTEQGM
AAELKQQIER NGMKGISNEL GLRVLHDVIK HQDKLGVIGC QAIKWKLFLH RYVEQPPFFA
NIEMDLQVAA QDSSAAIRSL PPAERRDYIK AQVAAAARQV LGSSAPPPFD TPLQDVGVDS
LGAVEFRNVL SKKLGIKLSA TTLFDYPTLN AIIDHICDVF GESSSEHQLD TKLGGMSENE
LAHGGMAVVS MSCRLPGNST CPDLFWDMLM RCTDCVCDIP LTRWNAEEVF SEDPDLPGKC
YIRRGAFIEN AEYFDNSFFG ISPSEVKHMD PQQRLLLEVS YEAFAAAGLT KEKLLGANVG
VFVGACNHDW TYLIQEEKIS AYTGTGSAGS VIANRVSYCL GLKGPSVPVD TACSSSLVAA
DYAFEKLVLR DCSMALVAGV NLMLTPHLFI AFSKARMLSP DCKCKTFDAS ADGYVRGEGA
GAVLILPVAE AKARQMTIHA VVKGTACNHV GRSASLTAPN GPSQAEVIRI ALRHAGMKPN
DVKFMECHGT GTSLGDPIEV NAMRTVFAPG REQSKPLLVG AVKTNIGHLE GSSGIAGLIK
ACLVLSHREI PPNLHFKTLN PHINIEDFPV RFITDFTSLD AVESCGKKNI AGVSSFGFGG
VNAHILLEEA TRDQSAVRKE ENRPKICFMF TGQGSQYIGM GRHLYEKEPV FHEAVNRCAE
IAKEYLPIPM LRVIYPTPDE REAMQEVIND TLYSQPAVFI VAYALLELWK TRGVEPDMVM
GHSLGEYVAA VCSGVLSVQD GLKLVLKRAQ IMSRVPPRNG VMVACRATPE QVDEAIQTLF
GDGEKNVSLG SVNGLKSVVV SGSQQDVQAV LRQLGVASRA KMLRVSHAFH SPLVRDTVAP
FKRVLETVRL NKPRIAFVST VTGKVAKDEL VSTQYWAEHI TKLVRFCDAV QTCVAHGAKI
MVEVGPRPTL TNMGKGCLSQ SAADEVQWIN SLEPESSTTA VFDSLSALAR SGGGAIPAVF
DRKFFPWTDT CHPLLGGKNT RPDGSVVYSA PLRDLVKSLF LDHVVYGKVL LPATCLIEMM
VSAAGHMISN RDEEKLMALT QVLFERPAIL PDDTQLNILV TVETRGQVRV ASQAVNSDDE
VEDHSVSQVN IVDAMPSAPA LSEIRARCKQ EIDAAQLYSQ LHAVGLQYGP RFQTILKVFK
GEDEVLGLLQ ARNPANFEKG FKMHPAVLDG ALQLSAVLAF EKGGTRAMVP FGVDTVLLKN
FPADKEMWAR VVLNKKGVSS AQVTVHLFDF EGELVSALVG VTLRHIEINT SADIPRELLW
EVQWEEAGSF SKFMESASNA EQLMEAEPEP LTRSSSTAEK MRAFDEPGKP KQVQLPLPEL
LNNTALPKHP RRNLLLIDYC GAHREAIAKL LDTFEGEVEV VCKPRSPEML EEQLQQFAEA
EGNTDADATA SHCSAVLFFA FAEVVSAEEL VAGLVEAAKV FAVRKVKKLP YLWVVTSGAQ
GPAKTVCSPK HSGLWGLMRT VRLELETHTG KAVKFGCFDF DKSLALEDVL DFILKKQSEE
PFEPELVLRP VKASISADDN TDNQQPVGSF LVPPKKAPSV GATDKPGILA EETSDEFSGE
ELDNEDKAHA GEQPVFQAYC ARLQRSPIVV RGPIELHMPE RGAISNLVLR PQAYATRTAP
QKNECEIRVR AIGLNFRDVL NVMGLYPGDP GPPGADCAGI VVGVGSEVKH LKVGDAVYGI
AQGCLRTYVT TNSELLRKMP ESLTFEQSAA LPVVAATVEY ALHDLAKVKA GDKVLVHAVS
GGVGLAAVQY CKRVGATVYG TCSGGKKAAF VKSLGVKYVT SSRDTAAFAE DMREFLGEDE
KIDVVLNSLI DNFIPESLKV LAPNGRFMEL GKRGIWTKEQ MAAERPDVYY ETIAVDCMMQ
DDPVWFGSML DRIRKCVDNG SLQPLPLHVF EMADPVGGGV SAFRFMQRAQ HIGKVVIRIG
SDLEVTAPEA LKETPTEDQA SSVHAEGGTT CGTGSDEARK TYVISGGTGG LGVVVAHWLV
EEGARHIVLL SRKGEPSSSV RESASWKFLT GADRPTCVNM LSLKCDVSEK EDVLRAFKEI
KAKGFPPVRG IFHAAGVTAD AALSNQTPEL IEQVYLPKVT GAWNLHEVCE TLGLNKDLEI
FVMFSSVAAL LGNFGQANYS AANACLDALA EYRRAQGLCG QSIQWGPWVE QGMASDFRQT
LDKVGMRGIS NELGTRVLSE LVRNTHRATT VLCQSVIWKK FLQRYDRVPP LLKNTRAGQG
ATADASLMLR TMTAEERRNY VEKTVREVVK QALGLAEPPP MDLPMQELGI DSIGAVELRN
ALSSRLGVKM PATAMFDYPT LDAMVDFINA TLAEQCSGAD QEPTADASMA LMPQMMHRLE
GNIAVTSAAV HLPGDVHTVD EFWTMLQQMR DCMTEVPLTR WNMYTFYDPD PDALDTSYAK
LGGFVHDADM FDNSCFNISP AEVRVMDPQQ RMILEVAYET MVGAGCAGSQ ASQQSTGCFI
GCCNADWHML DIPSGPFTGT GSSTSIISNR ISYTLGLRGP SLTVDTACSS SLVAMDSALC
KLSEGSCSGA LVGGVNLMLS PHLFICFSKA RMLSPDCRCR TFDHRANGYA RGEGAGAVLL
KPLNAARKEE GTILAVVRGS AINHDGRSAS LTAPNGPAQQ AVIRAALQSG GVKPTDITIL
EAHGTGTALG DPIEVGAIRA VFMQHRGADN PMYIGALKTN IGHLEGSAGI AAFIKLVLCL
RYREVPANLH FQQLNPHIDM TDFAAIFPKA TVDLPVNRKL FAGVSSFGFG GANAHVILEE
YFELSSSTEE TEKAAPVRWD RRCFPWYDPF HATLGHEVKT AGDDRKIEME IRRDVYDVLA
QHMVEGRPVM PAACYLETIT AACCCSEFVH PCSRKMLRPD HDACVTLEDI EFQRPMILEP
PAGDGLQSFQ VLSTILSANG NASIASSSAG DDEEVVHATC RVTSVDDRAA FSRTPEENLA
FLDEDTERVA LDAASMYAKL WKNGLMLGPQ FRTIASIECS SKSAKVRLQL PEPPSSCEVG
FRVHPCVLDG TFQTVGALVL AHDEMAKKEG AAQASLGSLK LMIPFMIQKI TLGSMKGVSN
GLWAHVALVK RESNQAIVNV DIMTDAGRPV CCLKELTMRR LDPTPVAEIP RELVWRTEWT
AGQQVDLVSP KNVNVVVIDH LGLHRAAIRE IKQFRFPSLQ VFERPSVAEL FPALEAGPPA
AGSQGDSGRS SGASEEASTA TVVLYLAMDG ESEAVEAVSG LMEITARIEK AAREDRQKAF
RPLWVVTRGA QSHSEDMPVS HPAHAGLWGF ARAARLEVPA QTGKELKLGC VDVLPGCSLP
SVIQRLAAIQ EQEKYEPEIL FHHVTVEEGN KSAKVLAHFV ARLARAPMNV RGALELHMPD
RGAITNLVLR PQAFASRIPP KGDTVELRVR AVGLNFRDVL NVMNLYPGDP GPPGADCAGT
VVAVGDRVKH LKVGDSVYGV APGCIKTYVT TNSQIIRKMP ASMSFEEAAA LPVVATTVEY
VLGDLAKVRA GEKVLIHAVS GGVGIAAIQF CKRVGAVVYG TCSSEKKREF VESLGVKYVA
SSRDPEKFTA EMKEFLGEEG KVDVVLNSLI DKFIPASLEL LGKEGRFMEL GKRGIWTHEQ
MKAARPDVYY ETVAIDVMMN ENPRWFGIML DRVRTLVERE QLLSLPLSVF NLHDPNEGGV
AAFRFMQKAQ HVGKVIIANP STLDFDRVTV GPPNTTEKTY VITGGLGALG LVVAKWLVEE
GARYIVLLSR KGEPSPAIKR SPVWLYLTDD EQTCVNVLPL KCDVAMKADV LRAFKEIKAK
GFPPVRGIFH AAGVTADAAL SNQTPELIEQ VYLPKVTGAW NLH
//
