ID A0A2C6KJW1_9APIC Unreviewed; 319 AA.
AC A0A2C6KJW1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=Defective in cullin neddylation protein {ECO:0000256|RuleBase:RU410713};
GN ORFNames=CSUI_009252 {ECO:0000313|EMBL:PHJ16928.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ16928.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ16928.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ16928.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- FUNCTION: Neddylation of cullins play an essential role in the
CC regulation of SCF-type complexes activity.
CC {ECO:0000256|RuleBase:RU410713}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ16928.1}.
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DR EMBL; MIGC01005463; PHJ16928.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C6KJW1; -.
DR VEuPathDB; ToxoDB:CSUI_009252; -.
DR OrthoDB; 169757at2759; -.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR Gene3D; 1.10.238.200; Cullin, PONY binding domain; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR014764; DCN-prot.
DR InterPro; IPR042460; DCN1-like_PONY.
DR InterPro; IPR005176; PONY_dom.
DR PANTHER; PTHR12281:SF31; DCN1-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12281; RP42 RELATED; 1.
DR Pfam; PF03556; Cullin_binding; 1.
DR Pfam; PF14555; UBA_4; 1.
DR PROSITE; PS51229; DCUN1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT DOMAIN 95..309
FT /note="DCUN1"
FT /evidence="ECO:0000259|PROSITE:PS51229"
FT REGION 68..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 35568 MW; 5B5D505BE5EDF301 CRC64;
MASRGCSSHP PSVVQQSLVD SFLSVTGFTN RTGAAEFLRR HSFDLSRALD AYFSLPPREQ
RAIQQFHGGG TSFESSSHSS LSSKGQAAAK ARAAERQRQI AETFQVYVHP TGTGAQQEVG
SSPSPDHAGG GADVVQLEGL ERLAQDLSVG LDDIFFLIFA FLCQCAEQGR ITKEEFCRGM
DRAGVSTVQE LREAVPRLRE TLTSDKGFAR QVYAFAFTYS LDIGQKSLPI DLCVAYWRLL
LSADDFPLMD EWITFIEEVY QKRVSMLSRD SWLMLFDFMQ SQGKSTNLDD YDEDGAWPLV
IDEFVEWARQ RRAGQKQGA
//
