ID   A0A2C6KSZ6_9APIC        Unreviewed;      1438 AA.
AC   A0A2C6KSZ6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Cytoplasmic dynein 2 heavy chain {ECO:0000313|EMBL:PHJ19465.1};
DE   Flags: Fragment;
GN   ORFNames=CSUI_006711 {ECO:0000313|EMBL:PHJ19465.1};
OS   Cystoisospora suis.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX   NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ19465.1, ECO:0000313|Proteomes:UP000221165};
RN   [1] {ECO:0000313|EMBL:PHJ19465.1, ECO:0000313|Proteomes:UP000221165}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wien I {ECO:0000313|EMBL:PHJ19465.1,
RC   ECO:0000313|Proteomes:UP000221165};
RX   PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA   Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA   Blake D.P., Joachim A.;
RT   "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT   vaccinology approach to identify vaccine candidates.";
RL   Int. J. Parasitol. 47:189-202(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHJ19465.1}.
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DR   EMBL; MIGC01003433; PHJ19465.1; -; Genomic_DNA.
DR   VEuPathDB; ToxoDB:CSUI_006711; -.
DR   OrthoDB; 275566at2759; -.
DR   Proteomes; UP000221165; Unassembled WGS sequence.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF07728; AAA_5; 1.
DR   Pfam; PF12774; AAA_6; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT   DOMAIN          335..454
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   DOMAIN          495..598
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   DOMAIN          733..871
FT                   /note="ATPase dynein-related AAA"
FT                   /evidence="ECO:0000259|Pfam:PF07728"
FT   REGION          279..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1438
FT                   /evidence="ECO:0000313|EMBL:PHJ19465.1"
SQ   SEQUENCE   1438 AA;  158448 MW;  E9360C5B50421D77 CRC64;
     MFPRFYFLSD DEVVEVLSLF AACSHPVRMS GEFLPRLHHR LWRKMFQGVQ RVILGDHDNI
     VPNPQASFIV LGGIEEEVVL VDVGLDGPQG VTGEGGSAET CLASLDVTLK DKLKELTETS
     IRALEKGSEQ ADEDRLLRDT PSQIGSLVFS VDLTKRTEEA ICSGTLRDLK QSLILKLRKL
     TNFLRHHRAE SLTGSFSLSA CSPPAASTVS VSGFTSSSQP SQSTKTPLEV SRTRFHVMFL
     TEQMKIVEEL ISESCGTLED WSWFKQLKFE RSLAVTLGPR QEGGGVGTEK PDQRATSTPR
     TLQFSQSHTN STEERRPPLR GVQYVARMAH CTQVYGFEYQ GAVPERVVYT PLTAKCYLSL
     LNGLELGLGG NPYGPAGTGK TETVKALGAA LARHVLVFNC EEGIDFRSMG RLIVGLGACG
     AWGCFDEFNR VLGEQLSAIS QFIFLFQKAV QTKRAPTLRA EGNAEEKDIW EELVRQAIGS
     KGDNKQRKVS FGLRSLDEKA ALFVTLNPAV GTYAGGRSEL PVNLKHLFRP VLMAKPDVRI
     IAEVFLLSEG FTDFKTLARK LACVFDEAAN LLPPQPHYDW GLRSVKTTLE VCADLFRCES
     MSPSILHNSD VTQASTNLGV HPLEPPSRTG GRLPHSHCGG IRFELTCMRR AIETTTVGRL
     VPGDADQFRR LLDATFLEIA EQGERQHQAP ATGHDVSMED VQRALVETGR LYEPEQGEKV
     LQLHACMQQR MGTIVLGPPG SGKTTIWRTL FHALRQSQGP LSQLRCVVVH PKAMPRRQLM
     GYREALTGEW KDGVLSRLAQ ELEKDESGNV WVVFDGDIDP EWAENLNSVL DDNHVFTLPT
     GRRFYLNSQR VKFIFETHQL TFASPATTSR CAAIFVPFQT NVKLLLHPPL LSYRENSSET
     PVLELDNDAL QALLRDVLKA LNYPPSLGSS CTDACSAAPS PVLTSIRRIF STAFTQMDWH
     SRKTQDDCCL PVEPRQGETP LKKKLSRLEG MQLLRVCLLH ALQPYLYQGP STSLVTALLP
     PETRGEYPAA DYFNLLGMPQ ENVTASPAEQ AENQADLSHT SGRTYISETL QSEAGCAKIP
     FIPVASSLKA AWALKPLLES GERCIVVVGN RGCGKEAVVR HLSTSCYGSF PGNRQILCSS
     ALIQATSGTN YGSSSTAFVR YACTPHTTVN DIVSTVRQYC TVAETSEGRT YRPAKPGKLL
     LYIKNIDAPV PDKYGVSEVI EWVRQVGCTS TFIDPDLKIC RLEQIQIVAS VAADVAGKTR
     GKELSIPTRL SACLPFVYIG EPSTTELEAI CNRLLQRHLV NAQEDTHQRE KFMATCFRLG
     SFLKDLREAI NRDRVDKGLT VCQVTCRDVV ECAKAICQHA VATVDQLQRV CLDEVSLQIV
     AGLGRSRAAQ QALGELVQSV AGKHEITLSA PELGEFFSTR LPGGGERRGH VFALAPFL
//