ID A0A2C6L5R7_9APIC Unreviewed; 387 AA.
AC A0A2C6L5R7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
GN ORFNames=CSUI_003380 {ECO:0000313|EMBL:PHJ22766.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ22766.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ22766.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ22766.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ22766.1}.
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DR EMBL; MIGC01001493; PHJ22766.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C6L5R7; -.
DR VEuPathDB; ToxoDB:CSUI_003380; -.
DR OrthoDB; 5474548at2759; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT DOMAIN 18..298
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT REGION 36..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 42823 MW; 95650CC31BF2EE66 CRC64;
MSTSSEAVEA PLELPVCLVT GGSGLLGHAL QTVLSRTTHK PNPSSPFPSS SPSSSSSCSP
PSSSSSPSSV EKSEGESSAA VSIPPPLAVL RGESFLFVFV GSKHANLRRF DEARRLFAAY
RPKAIIHLAA RVGGLFDNMA HNLEFFQENL EINENVVKLC HEFKVARGVF CLSTCIFPAK
YAEEGILMDE TCLHEGLPHP SNEGYSYAKR YLEISLRLHR QQYGWEWRCI SPTNLYGPFD
RFSLSRAHVL PALIHKAFLA SREDKPLVVG GSGRPLRQFV YSEDAAEIIL KVVHTPHMTE
DQSHLILADD NPEGVSIAEV AETIANEFSL SHPLQFDTSR PDGIFRKSVS NARLRRFLGP
DFQFVSLKEG ISRTVKWFKE NSTQIRP
//
