ID A0A2C6L7G8_9APIC Unreviewed; 419 AA.
AC A0A2C6L7G8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:PHJ23375.1};
GN ORFNames=CSUI_002776 {ECO:0000313|EMBL:PHJ23375.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ23375.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ23375.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ23375.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ23375.1}.
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DR EMBL; MIGC01001157; PHJ23375.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C6L7G8; -.
DR VEuPathDB; ToxoDB:CSUI_002776; -.
DR OrthoDB; 6339at2759; -.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT DOMAIN 29..160
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 179
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 274
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 419 AA; 44711 MW; FC806E0896460201 CRC64;
MASAGASNKN QEVETNASSI PADACKRVKV GVLGATGAVG QRFLCLLHNH PYFRVAAVGG
SSRSAGKRFA EAVTWRQDDD KALTEEILQM TVLECTCPAL FRQKGCALIF SALDAAAADE
LEELFAREGF MVFSNAKSHR MDPDVPILLP YVNAPLLDVV RAQAHYVKAR GGIVTNANCA
STGLVVALRP LLDRWGITRL SIATLQAISG AGYPGLSAMD MVDNVIPFIS GEEEKLEREP
QKMLGSLGSA GRSIQSASFE SVAMCHRVPV VDGHTVTVTV DFPSNAFPDT ADPLKVAAEV
TSVLGAFEPP KEVTALPSCP TQVTPFRLSQ VILVCEDPSR PQPRIDRLRG NGMSVSVGPV
KAKFLVHSKT WSVKFTTLVH NTVLGAAGCA ILNAELALHR GMIRDPNNQD GILEPVSCP
//
