ID A0A2C6LBM2_9APIC Unreviewed; 2322 AA.
AC A0A2C6LBM2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Sec63 domain-containing dead deah box {ECO:0000313|EMBL:PHJ24434.1};
GN ORFNames=CSUI_001711 {ECO:0000313|EMBL:PHJ24434.1};
OS Cystoisospora suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ24434.1, ECO:0000313|Proteomes:UP000221165};
RN [1] {ECO:0000313|EMBL:PHJ24434.1, ECO:0000313|Proteomes:UP000221165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wien I {ECO:0000313|EMBL:PHJ24434.1,
RC ECO:0000313|Proteomes:UP000221165};
RX PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA Blake D.P., Joachim A.;
RT "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT vaccinology approach to identify vaccine candidates.";
RL Int. J. Parasitol. 47:189-202(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHJ24434.1}.
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DR EMBL; MIGC01000678; PHJ24434.1; -; Genomic_DNA.
DR VEuPathDB; ToxoDB:CSUI_001711; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000221165; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT DOMAIN 623..808
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 843..1036
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1472..1611
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 24..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2322 AA; 259051 MW; 3DD15F7FB828F1A5 CRC64;
MAEEFERFKR FEYRQNSNLV LQRDTSTGGA PALHLTEPTG EPESLAGRKL YPMGDKVERG
LKKEEKQAGK VSAAQRKSKL RRNKLDIKRG ATVLDTDVTE IFFYKPTTQQ TRQVYEQLLV
TLQQQLGDQP DEVLKGAADE VLAALKVDGC KDSERKKNVE QVLGPLTSDR FSRLFQLAKN
ITDYSVGGEE EAGASGGGLD SNTGVAVVFD EEEEEDADGN DLMEVEVLDG DDEDEDEDEG
ETEDKERTYL ASKNLDDNED LEERDAYELD IAKIDPHWLQ RELNNIFGDP NRAVATEKEI
LSILATPDIQ ECENKLVVIL KYENFELAKL ILKNRWKIFY AVRLGQAQSK EEKNAIYEEM
KNTPEGQEVL ELLDSLSSRR NKEKEMAINV RKEAASLAAK AQARAAASLR ALEFADEDEA
GTRTGGGAGA GGSSSSATSG SGAVGSSSTG TGTGTSVSGS GGVSSSSGSS SSRREGLDDG
KGGGAGPSSS SSRSGQGFAA GSSGGVGGGG GLGGTSSSTS VGGGLKGSGA GAALKPTATV
DLGALTFHQG GHLMSNVRVK LPDGAQRIET KSYDEVIVQA FKKPQTDSDS RVSVSSMPTW
AQDAFKVANI EQLNAMQSKV YKVAFEDFKE NLLLCAPTGA GKTNVAMLAM LNVVGRYRNP
KAGGAIDLSG FKIIYISPMK ALVAEQVQAF TQRFQPYGIT VRELTGDVNL TRQQIEDTQV
IVTTPEKWDI ITRKAGERAY TQLVRLVIID EIHLLHDTRG PVLESIIART IRQIETAQEH
IRLVGLSATL PNYEDVAVFL RVRPERGLFF FGNHYRPVPL KQTYIGIKDK KAIKRYNTMN
EVTYEKLMES AGKSQVLIFV HSRKETVKTA RFIRDMALQK DTLPRFLQHM TASREILQAE
AEAVKTSDLK ELLPYGFAVH HAGLPRTDRK LVEDLFADRH VQVLVSTATL AWGVNLPAHT
VIIKGTQVYL PEKGTWSELS PMDVLQMMGR AGRPQYDTAG HAILITQHSE LQYYLSLNNQ
QLPIESQMIS CLPDMLNAEV VLGSVRSRED AVNWLGYTYL YVRMLKNPSL YGIPPDEAAH
DKLLEQHCVN LVDSALKILD KNFLIKYDRR VGCIQVTALG RVASHYYIKY PTIAIYNQHM
KPLMSDIELL RLFSLSSEFK YMPVREEEKV ELQRLMERVP IPVKGSPDET SSKVNVLLQA
YISKLKLEGL AMMADMVYVQ QSANRIMRAI FEICLRRGWA MLAMRALQFC KEIDRRMWST
MTPLRQFKVL PEELLRKIEK KDLPFERYYD LTSTEIGELV RVPKMGKLLH RLIHQFPKLE
LAAFVQPLTR TCLVVELTIT PDFQWDFKVH GTGEVFWIIV EDVDGEQILH HEMFIMPPFT
GEVEHTLCFT LPITDPLPPN YSIRVVSDRW LRSQSSLPIS FKTLILPERT PPHTELLDLQ
PLPITALRNS TAEQIYSGSF KAFNPIQTQV FSTLYTTNEN VLLCLPPTSG KEVCLEFALL
RMFNTEPSNQ WKAVYIAPHP MVVKERFEDW VAKLGRGMGV KLAELTGEMQ HDLKLLEQSQ
VVLATPEKWD FISRRWKTRK VLQSIRLLLV DDLHLLNSSM GSTLEVCLSR TRYISAQLQR
PIRVVAIGNS LANAKDVGDW LGVSSTGLFN FHPSVRTIPL EISLHGFDVY NREARLLAMS
KAVYQAIKLY TSVGDDEPGG SVHSSSSRKL KNVIVFCSDR RHCRLAAIDL LLQAAADDDP
KKFLHVSDAV MSKYTSVVRD KMLLETLSYG VGLFHSGLSE AEQQLVQQLH AGGAIQVVVV
AEECAWGLQM YAHLVVVVDT KKYTENGYED YTVADVLQML GHATRPAVDK HGYAVLFCPS
SKREFYKKFI FEPLPVESQL EQNLVDHVNA EVVLKTIENK QDAVDWLTWT FLYRRLAKNP
NYYGLQGVSH QHLSDYLSEL VESSVHTLEQ AQCVSEHNDV DLEPLNLGLI AAFYYVKVNT
IELFNRSLTP TCKRRALLEI LAASSELSTI PLRPGEEGTL RGLAQRLGVR LSQNSEDINK
PSTKALILLY AHFNRLPLPS DLVADQKFVL EPCIRLLHAL VDVISSNGWL VPALSAMEIC
QAVVQAMTTT ALGGGNATQC SPLKQLPHFT DELIETAKEM GVEDIFDLMN MEDKEREKLL
KPLTPSQLKA SVYTSSLPKL RMRETVLLPF ACLFPQDVAK ASNRYPVINV EYHLSKKDDI
APNESIQCTV TLERDCAETQ GLVYAPFFPR EKEEQWWLVV GQASSNSLAA IKRLTMNKQT
TTVNLSFDAP ETPGKHTYVL YLMGDSYVGG DQEYKLDFRV RA
//
