ID A0A2C9A151_9MICO Unreviewed; 573 AA.
AC A0A2C9A151;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SAMN06296378_2533 {ECO:0000313|EMBL:SOE72541.1};
OS Salinibacterium xinjiangense.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Salinibacterium.
OX NCBI_TaxID=386302 {ECO:0000313|EMBL:SOE72541.1, ECO:0000313|Proteomes:UP000219440};
RN [1] {ECO:0000313|EMBL:SOE72541.1, ECO:0000313|Proteomes:UP000219440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.05381 {ECO:0000313|EMBL:SOE72541.1,
RC ECO:0000313|Proteomes:UP000219440};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; OCST01000005; SOE72541.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9A151; -.
DR Proteomes; UP000219440; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06577; PASTA_pknB; 2.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; NF033483; PknB_PASTA_kin; 1.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:SOE72541.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000219440};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:SOE72541.1};
KW Transferase {ECO:0000313|EMBL:SOE72541.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..286
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 372..437
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 438..511
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT BINDING 45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 573 AA; 60362 MW; 174EDEF66C63680D CRC64;
MIEGVAQGVR ELAGRYQVGD LLGHGGMADV HVGTDNRLGR RVAIKLLKPS LAQDPAFRTR
FRREAQDAAK MAHPTIVRIF DAGEESVRDD RGAEVLVPYI VMEYVDGQLL KDIVARGPLE
PAEACRITGQ VLTALEYSHR AGVVHRDIKP GNIMITTGGQ VKVMDFGIAR AISDSSATIA
ETSAIVGTAA YFSPEQARGE TVDARTDLYS TGIMLFELLT GRTPFRGENP VAVAYQHVNS
DAAAPSSLNP RVSPALDAVV LRSLAKDRFG RYQSASDFRA DVETAAAGSV PVRKQVATND
FNSTLFGVNP TSTAGSEAAI RQLTVDRDDR VARTQNRPPV AWIWAGIVTM VAVIVAVIFW
TFNLTPANLA PNLSRDVPSV VGQSYEAGAA TLEGSDLVPR KLTESSADIP ENVIIRTDPV
SGIPVSPGTA IKVFVSSGEV TVAVPDVSRL TEADAIAGLE ARKLVYGTTA RDYSPDLPNG
AVIRSDPAAG ATVVSGENIR EGDTVDLIVS NGLVNVPDLA GSSLKNANDA LSALQLPVSV
TADRGCSGGT VSGQSVVGEQ AQKTAVTLRV CSA
//
