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Database: UniProt
Entry: A0A2C9C370_CAEEL
LinkDB: A0A2C9C370_CAEEL
Original site: A0A2C9C370_CAEEL 
ID   A0A2C9C370_CAEEL        Unreviewed;      5070 AA.
AC   A0A2C9C370;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:SOF58817.1};
GN   Name=unc-68 {ECO:0000313|EMBL:SOF58817.1,
GN   ECO:0000313|WormBase:K11C4.5p};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:SOF58817.1}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5p};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:SOF58817.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:SOF58817.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:SOF58817.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; SOF58817.1; -; Genomic_DNA.
DR   WormBase; K11C4.5p; CE52083; WBGene00006801; unc-68.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   ExpressionAtlas; A0A2C9C370; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A2C9C370,
KW   ECO:0000213|PeptideAtlas:A0A2C9C370};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4435   4458       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4621   4638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4684   4706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4822   4844       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4864   4889       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4949   4968       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    271       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      277    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1004   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1475   1694       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4181   4216       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4219   4251       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4194   4205       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4229   4240       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     1024   1044       {ECO:0000256|SAM:Coils}.
FT   COILED     4468   4490       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5070 AA;  576290 MW;  EA243A4995AB968F CRC64;
     MDFDFTDISD EDHNYVTKGD IVCLSCVASH NRDGVLGSER VCLCTEGFGN RMCTLENVSD
     KDIPPDIAMC MLYIDNALSM RALQEMMSAD SDHKSASGAG GHKTLLYGHA VQLKHVQSEM
     YLACLSSCSS NDKLAFDVGV QETNEGEACW WTIHPASKQR SEGEKVRVGD DVILVSVATE
     RYLHMAYSKG YMVIASFHQT LWNIQSVSSG SMRTRNMGFL FGNDVLRLFH GNDECLTIPE
     NWSEHPQHNM VIYEGGAAVT QARSLWRVEL IRMKWHGALV GWEQVFRIKH ITSGRYLGVL
     DNSVQLYHKE KADFDLTAFV MCQNKDPKKQ MLDEKEEEGM GNATIRYGET NAFIQHVKTQ
     LWLSYQTTEV TKKGLGKVEE KKAVALKDGH MDDCYTFFMA LEEESKSARV IRKCSSVLNK
     FLKGIDALQL EGNQSTDWTR VDLNEVLKLM EDLIEYFAQP NDEQDFEEKQ NHLRALRSRQ
     DLFQEEGVLN MILDTIDKFS QMEALPDFAG LIGEETHVKW EQISTYLYLL VAAMIKGNHY
     NCAQFASAQR LDWLFGRLSN PQSAEGILDV LYCVLTESPE ALNMINEGHI RSVISLLEKV
     GRDPKVLDVL SSLCEGNGMA VRSSQNLITQ YLLPGKDLLL QTSMRDHVSS MMPNVMLGVV
     EGSALFRKWY FEAEVEHIET MTKQTPYLRI GWANSVGFKP FPGSGDKMGC NGVGDDFYSY
     GFDGKSMYFG GKSRRVGHKL LEKGDVIGCS IDLTIPEIKF SVNGTYMSGS FKKFNIDGYF
     FPVMSLSAKV SCRFILGGNQ GRLRYGPPTG FSAVVEAVNG ELQITDCLSF GDLGKNIFSG
     PQTIFNNLEP FIPTPIDVSA TQLNHHATEM HQKYAENLHE LWAMRKIELG WSYGETRSET
     SRKHPCLTKF EYLPETEKKY NILLALTTMK TIEALGYHLI TEDPPCRLRA VRLGPNFQQQ
     NGYKPGPLDT HEIQLPAELQ PLTEALARNT HNIWAKEKIK RGWTFGLSEH VDATQKRSPH
     LVPYEQVDER IKQANRESAA ENIRALQLFG IFLEPPAHEH DEVAEKELRA RKDNTRTYRA
     EATYAVCGGK WYFEFEILTA GYMKIGWMDI GSTPEIQLGA DDRSYAFDGY LGRKWHQGAE
     TYGKEWKIGD VVGCFLDLND RTISFSLNGE LLLDPSGSEM AFDNVVCGDG LVPAMTLGSG
     QRGRLNFGQQ SNSLKFFTTC GLQEGYEPFC VNMYRTMPMW FAKQLPRFED ISTLKSGSIL
     EVSRIPATGN SPPCLKILQK VTISEGGPSE KAKMEYIKLS LPVKCNDTFV KNKDKETIRR
     QLQEYKPRSQ SVVSQIRAPG IPKEFDDNKE KKGFLRSMLG SKDSHESDDD RRSRTNSKQP
     SVDGDEPPAV RRSLLELPHD ERQIAEDSMR DLNDRHSEKP KKGGLLSRLR DSSNTRKNFR
     DSDRRKEEKA AQLRQMKANS RSFDAGSLDT STLPTGQKDV LASSEMPLSG PGRQLTIKRS
     SIKKNKKGKK AEIALEKMER EKKGSIIPMD AQLDVLQEGD AHALVHHKDK VDEYYYGIRI
     FPGQDPSQVW VGWVTTQYHY YNVNFDGSQG VRKCRFSEAD HHGTTVDSVQ SQNCYMVNVS
     ELLATTPDVA NTKVSGTLIG CIIDTSIGEL SFQVGSTDTG IKFKLEPGAM LFPAAFVTPT
     ATEILQFELG RIKYTFPLSA AMFKSCEKSL VPFCPPRLTV EQIESVYWAR VPNETLRTTA
     LKLSEVRGWS VLCNDPVRIM SVYIPEKDQS LDILEMIEMP DMLEFHRQTL NLYCKLASHG
     NHKVAHTLCQ HIDEDQIMYA IKSHYLSGPM RQGFHDLLIG LHLMSHTAAR NSMAKEYVIP
     LVPQLQIKNV LDPDSESRYP QITGESVSML SQMASEPVKK HVSREDEMKL LPPSVDFEAL
     KKHVMESLQS ATHHAVMNCR DLIGGDNTNH FEPLFKLFDQ LLVIGLINDE ELECLLRLIH
     PQAFDENYET GTTQKGLTQL ELAEPVKIQL VSILDHLCDI QLRYRIESLV AFTEGFVGEL
     QSDQCKRYME IKQTDMPPAE AAKKTKEFRC PPKEQMFRLL MCKVKEERDP ELMEEDADVD
     QCPMAEGLQQ QLRDFCELLV GKIGNVKEGD SDDQLALIES EEGSWVDSFA RIVVKVPPPV
     LEEGMEMQKK GTQNFREIIV TMLREWAQAD FIESKSLIRN MFRLLLRQYS GIREIRDAMS
     QTYVFHERNE KDVTDFLVYL IQIRELLTVQ FEHTEEAILK RGLWKLMNNR IFFQHPDLMR
     LLSVHENVMS IMMNILTAQQ GTVEHEGDEL KEKAPIKDAS EMVVACSRFL CYFCRTSRQN
     QKAMFEHLSF LLDNATMLLA RPSLRGSVPL DVAYSSFMDN NELALALKEE ELDKVAVYLS
     RCGLQPNSEL ITKGYPDIGW DPVEGERYID FLRFCVWING ENVEENANLV IRLLIRRPEC
     LGVALKGEGQ GLFSAFKEAI ALSEDIRLLE NDSHPSLLSS GLLGENPTYP SKDAEGEDYI
     DLGAATLDFY SSLVDLLAKC APDPMAIQAG KGDSLRARAI LRSLISLDDL GQILALRFTI
     PNLAAPSIED TGPLPGLLPN HKGSVLLFLD RVYGIDQQDM LFHVLEQSFL PDLRAATMMD
     SPRALESDTA LALNRYLCNS VLPLLTNHSH FFADAEHHSA LLDATLHTVY RMNRLKSLTK
     NQRDAVSDFL VAITRELPPA MMIKLLKKVI TDILTMNDMN VLVPLRLITL HYERCGKYYG
     SGNHYGVASE QEKRLSMLLF DAIFDTLGSR PYDPELFGKA LPCMTAIGSA ISPDYTLTSG
     LEDVRNKRRE EEGAWIPRTV DVSRCEINRD LEKMTELFAE HFHDSWASRK LEKGWVHGDL
     YSRANFTHPR LKPFALLKDF EKSFYKERCS ECLKALMAWN YSFEMMDRDA NDRASAARTL
     SGTSISNFAP KPIDLSSMTL EKDMVNAAEK MAEHSHLIWA KKVMNDLNTK GGFMPIPLVP
     WDLLTDFERR KDRFRASEIL KFLQYHGYHV NCPKDEQSQN DRLKSEGERT SVEKRFAYNL
     LEKLITYLEQ ASLKMKSVKP SQELTRRNSF KKEGQDVKFF EKVVLPLMHA YFNAHKNYFL
     EGSSIVQTGT ASNKEKEMVA NLFCRLAALL RIKNRAFGSV AKITVKCLQG LTQALDLRTL
     VKVNSDIVRT SLLTFFNNCA DDLYASVNEL KDGGQYSLIR GQALKSWNSF EFANQMIVPV
     LTTMFAHLAR NHFGTDLLLD DIQAACYKIL DSLYMVTGLS SSISHRKSIS GESEKHRPGL
     GQCLAAFASC FPVAFLEPEF NKSNKFSVLA KSQDQSVQVQ EMLQNLSTHI PHLEKLLTDL
     ETVANNNTMY SDVPNVYDVD LPLMCSYMAH WFSVGPDGKR DKEDQRASVV QTTSVSCDHI
     NRIFNALLKM IRNHVGIENA PWLCRVNFFA VQIIQNVTSD PVREFVLPIA ERLRRMSEKA
     YKEEEHMRTH PDDADEGTVA EDNARLVRDT YAFFPILMKY TDLHRAQWLK TPTWETDGVY
     ENVAVIFRIW SQSQHFKREE LNYVAQFEED AAATGGGDMK TGKAAIAERK KKRREGQIKK
     DKHAASIVIA CLKRLLPVGL NVFGGRELDI VQQSKEKFIQ KETEEKIREF IKGLLEIPVK
     TDPTDKNAWQ LSLYRKIGKS QMRGKDEMSQ DAVIEKIFNM GQVSAILHTT EHPQMQLSQA
     WKKVVSTQRK RAVVACFRMV PLYGIPRHRG INFFLPAFSR LWMEEEDAGQ DQLIADICSG
     VEEEEGPRIE IIMEEGVPIV ASSEDTKEKE TNPDPLKQLI RCFQRAATSE ETAASAIHED
     SLYIRFADVM AKSIHIEEED GEDGEEGEID QAAKEEQSQA LRGEQAVLAS RGAAIMCLMY
     LSASGGEPNE MVAQTLQLGI HLLSGGNVEI QKMLIEYLQL KKDVRFFTSM AGLMNKCSVL
     NLEMFERQIK AEGLGMGAEL ASGDNQNLND ADFTCSLFRF LQLTCEGHNL EFQNYLRTQP
     GHTTSVNLIN CTVDYLLRLQ ESVMDFYWHY SSKEVIDEGG KEYFLRAIQV CSQVFNTLTE
     SIQGPCVGNQ MTLANSRLWD AINGFFFLFA HMMEKLYKNS TQLELLREFL NLQKDMIVLM
     LSMLEGNVLN GSIGKQMVDA LVESQPSVEK ILKFSDMFLK LKDLTTSQAF QDFDTNQDGW
     ISPKEFQRAM ESQKMYTVED ITYLMMCTDV NNDGKVDYME FTERFHNPAR DIGFNLAVLL
     VNLKEHITND PRLEKIIEKA QTLLEYFDPF LGRIEIMGSS KRVEKIYFEI QESWLEQWGK
     QQIRDSKNSF LFNVLQDDGG DQGKLEAFIN FCEDTIFEMQ HAAAISSGDS DTKMERAIKQ
     RDYFLQQTSA DHISETFKSG YNYGISAASA LSPQNISTTM RNVSSSVRQM SWTQLLYAVI
     ILFIRAGLAI GWAGYLLLMT IFRFGYFLTT SSEEEEAARQ EKEQAKMNNE HPSFNPPIIQ
     EFHHSHVGVT AFGVGMNADH LNVNSLPDFV PPERPETPET VLEEEKPLNQ ETSPPTSPTS
     PASKAPSIYE SIGAPQMVQL QSEADFQQGQ YEPKIAESNS TKSRGSILNM LARNFKTIEK
     ITLYLAFFIN VILLFHRVDI SHAENAEAAS EGDDDEDALE SIFITGMQFP YVEYEITGWM
     LAQILYWISV LHLSTSFALL VSFYQLKIPL ITFKREKEIA RKLMFDGCWI TEEDSEELGI
     VDTFMWYLDR IVVSAKSFPM MYWDKFVRRK TRSKFKDQVD EETLTSILGE EKMSTDSSYD
     YRYSCWLWIG VILTNGQFLY RVGYLLCSAC GVFLSPFFYA FHLIDVVLSF PMLKAILQSV
     THNLQQLILT IMMTLVVVYL YTVIAFNFFR KFYVQEGEEG EEPDRKCHNM LTCFIYHFYA
     GVRAGGGIGD ELESPYGDDL EYPRMFYDIS FFFFVIIILL AIMQGLIIDA FGELRDQQES
     ATEKLESSCF ICDIGKETFD RMPRGFEIHT TKEHNFANYL FFLQHLVNKD ETEYTGQETY
     VREKYDNRDW DFFPVGECFV KQYEDQLLQS
//
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