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Database: UniProt
Entry: A0A2C9C384_CAEEL
LinkDB: A0A2C9C384_CAEEL
Original site: A0A2C9C384_CAEEL 
ID   A0A2C9C384_CAEEL        Unreviewed;      5200 AA.
AC   A0A2C9C384;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:SOF58814.1};
GN   Name=unc-68 {ECO:0000313|EMBL:SOF58814.1,
GN   ECO:0000313|WormBase:K11C4.5m};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:SOF58814.1}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5m};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:SOF58814.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:SOF58814.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:SOF58814.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; SOF58814.1; -; Genomic_DNA.
DR   WormBase; K11C4.5m; CE52191; WBGene00006801; unc-68.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   ExpressionAtlas; A0A2C9C384; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A2C9C384,
KW   ECO:0000213|PeptideAtlas:A0A2C9C384};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4565   4588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4768       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4814   4836       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4952   4974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4994   5019       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5079   5098       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    271       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      277    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1004   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1475   1694       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4311   4346       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4349   4381       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4324   4335       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4359   4370       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     1024   1044       {ECO:0000256|SAM:Coils}.
FT   COILED     4598   4620       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5200 AA;  590824 MW;  34FC520F1E497953 CRC64;
     MDFDFTDISD EDHNYVTKGD IVCLSCVASH NRDGVLGSER VCLCTEGFGN RMCTLENVSD
     KDIPPDIAMC MLYIDNALSM RALQEMMSAD SDHKSASGAG GHKTLLYGHA VQLKHVQSEM
     YLACLSSCSS NDKLAFDVGV QETNEGEACW WTIHPASKQR SEGEKVRVGD DVILVSVATE
     RYLHMAYSKG YMVIASFHQT LWNIQSVSSG SMRTRNMGFL FGNDVLRLFH GNDECLTIPE
     NWSEHPQHNM VIYEGGAAVT QARSLWRVEL IRMKWHGALV GWEQVFRIKH ITSGRYLGVL
     DNSVQLYHKE KADFDLTAFV MCQNKDPKKQ MLDEKEEEGM GNATIRYGET NAFIQHVKTQ
     LWLSYQTTEV TKKGLGKVEE KKAVALKDGH MDDCYTFFMA LEEESKSARV IRKCSSVLNK
     FLKGIDALQL EGNQSTDWTR VDLNEVLKLM EDLIEYFAQP NDEQDFEEKQ NHLRALRSRQ
     DLFQEEGVLN MILDTIDKFS QMEALPDFAG LIGEETHVKW EQISTYLYLL VAAMIKGNHY
     NCAQFASAQR LDWLFGRLSN PQSAEGILDV LYCVLTESPE ALNMINEGHI RSVISLLEKV
     GRDPKVLDVL SSLCEGNGMA VRSSQNLITQ YLLPGKDLLL QTSMRDHVSS MMPNVMLGVV
     EGSALFRKWY FEAEVEHIET MTKQTPYLRI GWANSVGFKP FPGSGDKMGC NGVGDDFYSY
     GFDGKSMYFG GKSRRVGHKL LEKGDVIGCS IDLTIPEIKF SVNGTYMSGS FKKFNIDGYF
     FPVMSLSAKV SCRFILGGNQ GRLRYGPPTG FSAVVEAVNG ELQITDCLSF GDLGKNIFSG
     PQTIFNNLEP FIPTPIDVSA TQLNHHATEM HQKYAENLHE LWAMRKIELG WSYGETRSET
     SRKHPCLTKF EYLPETEKKY NILLALTTMK TIEALGYHLI TEDPPCRLRA VRLGPNFQQQ
     NGYKPGPLDT HEIQLPAELQ PLTEALARNT HNIWAKEKIK RGWTFGLSEH VDATQKRSPH
     LVPYEQVDER IKQANRESAA ENIRALQLFG IFLEPPAHEH DEVAEKELRA RKDNTRTYRA
     EATYAVCGGK WYFEFEILTA GYMKIGWMDI GSTPEIQLGA DDRSYAFDGY LGRKWHQGAE
     TYGKEWKIGD VVGCFLDLND RTISFSLNGE LLLDPSGSEM AFDNVVCGDG LVPAMTLGSG
     QRGRLNFGQQ SNSLKFFTTC GLQEGYEPFC VNMYRTMPMW FAKQLPRFED ISTLKSGSIL
     EVSRIPATGN SPPCLKILQK VTISEGGPSE KAKMEYIKLS LPVKCNDTFV KNKDKETIRR
     QLQEYKPRSQ SVVSQIRAPG IPKEFDDNKE KKGFLRSMLG SKDSHESDDD RRSRTNSKQP
     SVDGDEPPAV RRSLLELPHD ERQIAEDSMR DLNDRHSEKP KKGGLLSRLR DSSNTRKNFR
     DSDRRKEEKA AQLRQMKANS RSFDAGSLDT STLPTGQKDV LASSEMPLSG PGRQLTIKRS
     SIKKNKKGKK AEIALEKMER EKKGSIIPMD AQLDVLQEGD AHALVHHKDK VDEYYYGIRI
     FPGQDPSQVW VGWVTTQYHY YNVNFDGSQG VRKCRFSEAD HHGTTVDSVQ SQNCYMVNVS
     ELLATTPDVA NTKVSGTLIG CIIDTSIGEL SFQVGSTDTG IKFKLEPGAM LFPAAFVTPT
     ATEILQFELG RIKYTFPLSA AMFKSCEKSL VPFCPPRLTV EQIESVYWAR VPNETLRTTA
     LKLSEVRGWS VLCNDPVRIM SVYIPEKDQS LDILEMIEMP DMLEFHRQTL NLYCKLASHG
     NHKVAHTLCQ HIDEDQIMYA IKSHYLSGPM RQGFHDLLIG LHLMSHTAAR NSMAKEYVIP
     LVPQLQIKNV LDPDSESRYP QITGESVSML SQMASEPVKK HVSREDEMKL LPPSVDFEAL
     KKHVMESLQS ATHHAVMNCR DLIGGDNTNH FEPLFKLFDQ LLVIGLINDE ELECLLRLIH
     PQAFDENYET GTTQKGLTQL ELAEPVKIQL VSILDHLCDI QLRYRIESLV AFTEGFVGEL
     QSDQCKRYME IKQTDMPPAE AAKKTKEFRC PPKEQMFRLL MCKVKEERDP ELMEEDADVD
     QCPMAEGLQQ QLRDFCELLV GKIGNVKEGD SDDQLALIES EEGSWVDSFA RIVVKVPPPV
     LEEGMEMQKK GTQNFREIIV TMLREWAQAD FIESKSLIRN MFRLLLRQYS GIREIRDAMS
     QTYVFHERNE KDVTDFLVYL IQIRELLTVQ FEHTEEAILK RGLWKLMNNR IFFQHPDLMR
     LLSVHENVMS IMMNILTAQQ GTVEHEGDEL KEKAPIKDAS EMVVACSRFL CYFCRTSRQN
     QKAMFEHLSF LLDNATMLLA RPSLRGSVPL DVAYSSFMDN NELALALKEE ELDKVAVYLS
     RCGLQPNSEL ITKGYPDIGW DPVEGERYID FLRFCVWING ENVEENANLV IRLLIRRPEC
     LGVALKGEGQ GLFSAFKEAI ALSEDIRLLE NDSHPSLLSS GLLGENPTYP SKDAEGEDYI
     DLGAATLDFY SSLVDLLAKC APDPMAIQAG KGDSLRARAI LRSLISLDDL GQILALRFTI
     PNLAAPSIEA VRRANAVQAS HTQKAVMAHT FAMVASLASE VSNTRRSQTF TSGTNLAKRG
     LPCVEEVDTD DSKSSDYASV HTSFSSGNEL FAPKAEKEKV DVLKLNENKY PIIQRRRSSR
     FNPIDNTGPL PGLLPNHKGS VLLFLDRVYG IDQQDMLFHV LEQSFLPDLR AATMMDSPRA
     LESDTALALN RYLCNSVLPL LTNHSHFFAD AEHHSALLDA TLHTVYRMNR LKSLTKNQRD
     AVSDFLVAIT RELPPAMMIK LLKKVITDIL TMNDMNVLVP LRLITLHYER CGKYYGSGNH
     YGVASEQEKR LSMLLFDAIF DTLGSRPYDP ELFGKALPCM TAIGSAISPD YTLTSGLEDV
     RNKRREEEGA WIPRTVDVSR CEINRDLEKM TELFAEHFHD SWASRKLEKG WVHGDLYSRA
     NFTHPRLKPF ALLKDFEKSF YKERCSECLK ALMAWNYSFE MMDRDANDRA SAARTLSGTS
     ISNFAPKPID LSSMTLEKDM VNAAEKMAEH SHLIWAKKVM NDLNTKGGFM PIPLVPWDLL
     TDFERRKDRF RASEILKFLQ YHGYHVNCPK DEQSQNDRLK SEGERTSVEK RFAYNLLEKL
     ITYLEQASLK MKSVKPSQEL TRRNSFKKEG QDVKFFEKVV LPLMHAYFNA HKNYFLEGSS
     IVQTGTASNK EKEMVANLFC RLAALLRIKN RAFGSVAKIT VKCLQGLTQA LDLRTLVKVN
     SDIVRTSLLT FFNNCADDLY ASVNELKDGG QYSLIRGQAL KSWNSFEFAN QMIVPVLTTM
     FAHLARNHFG TDLLLDDIQA ACYKILDSLY MVTGLSSSIS HRKSISGESE KHRPGLGQCL
     AAFASCFPVA FLEPEFNKSN KFSVLAKSQD QSVQVQEMLQ NLSTHIPHLE KLLTDLETVA
     NNNTMYSDVP NVYDVDLPLM CSYMAHWFSV GPDGKRDKED QRASVVQTTS VSCDHINRIF
     NALLKMIRNH VGIENAPWLC RVNFFAVQII QNVTSDPVRE FVLPIAERLR RMSEKAYKEE
     EHMRTHPDDA DEGTVAEDNA RLVRDTYAFF PILMKYTDLH RAQWLKTPTW ETDGVYENVA
     VIFRIWSQSQ HFKREELNYV AQFEEDAAAT GGGDMKTGKA AIAERKKKRR EGQDKMKEYF
     DRNGRPIIKK DKHAASIVIA CLKRLLPVGL NVFGGRELDI VQQSKEKFIQ KETEEKIREF
     IKGLLEIPVK TDPTDKNAWQ LSLYRKIGKS QMRGKDEMSQ DAVIEKIFNM GQVSAILHTT
     EHPQMQLSQA WKKVVSTQRK RAVVACFRMV PLYGIPRHRG INFFLPAFSR LWMEEEDAGQ
     DQLIADICSG VEEEEGPRIE IIMEEGVPIV ASSEDTKEKE TNPDPLKQLI RCFQRAATSE
     ETAASAIHED SLYIRFADVM AKSIHIEEED GEDGEEGEID QAAKEEQSQA LRGEQAVLAS
     RGAAIMCLMY LSASGGEPNE MVAQTLQLGI HLLSGGNVEI QKMLIEYLQL KKDVRFFTSM
     AGLMNKCSVL NLEMFERQIK AEGLGMGAEL ASGDNQNLND ADFTCSLFRF LQLTCEGHNL
     EFQNYLRTQP GHTTSVNLIN CTVDYLLRLQ ESVMDFYWHY SSKEVIDEGG KEYFLRAIQV
     CSQVFNTLTE SIQGPCVGNQ MTLANSRLWD AINGFFFLFA HMMEKLYKNS TQLELLREFL
     NLQKDMIVLM LSMLEGNVLN GSIGKQMVDA LVESQPSVEK ILKFSDMFLK LKDLTTSQAF
     QDFDTNQDGW ISPKEFQRAM ESQKMYTVED ITYLMMCTDV NNDGKVDYME FTERFHNPAR
     DIGFNLAVLL VNLKEHITND PRLEKIIEKA QTLLEYFDPF LGRIEIMGSS KRVEKIYFEI
     QESWLEQWGK QQIRDSKNSF LFNVLQDDGG DQGKLEAFIN FCEDTIFEMQ HAAAISSGDS
     DTKMERAIKQ RDYFLQQTSA DHISETFKSG YNYGISAASA LSPQNISTTM RNVSSSVRQM
     SWTQLLYAVI ILFIRAGLAI GWAGYLLLMT IFRFGYFLTT SSEEEEAARQ EKEQAKMNNE
     HPSFNPPIIQ EFHHSHVGVT AFGVGMNADH LNVNSLPDFV PPERPETPET VLEEEKPLNQ
     ETSPPTSPTS PASKAPSIYE SIGAPQMVQL QSEADFQQGQ YEPKIAESNS TKSRGSILNM
     LARNFKTIEK ITLYLAFFIN VILLFHRVDI SHAENAEAAS EGDDDEDALE SIFITGMQFP
     YVEYEITGWM LAQILYWISV LHLSTSFALL VSFYQLKIPL ITFKREKEIA RKLMFDGCWI
     TEEDSEELGI VDTFMWYLDR IVVSAKSFPM MYWDKFVRRK TRSKFKDQVD EETLTSILGE
     EKMSTDSSYD YRYSCWLWIG VILTNGQFLY RVGYLLCSAC GVFLSPFFYA FHLIDVVLSF
     PMLKAILQSV THNLQQLILT IMMTLVVVYL YTVIAFNFFR KFYVQEGEEG EEPDRKCHNM
     LTCFIYHFYA GVRAGGGIGD ELESPYGDDL EYPRMFYDIS FFFFVIIILL AIMQGLIIDA
     FGELRDQQES ATEKLESSCF ICDIGKETFD RMPRGFEIHT TKEHNFANYL FFLQHLVNKD
     ETEYTGQETY VREKYDNRDW DFFPVGECFV KQYEDQLLQS
//
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