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Database: UniProt
Entry: A0A2C9C3E8_CAEEL
LinkDB: A0A2C9C3E8_CAEEL
Original site: A0A2C9C3E8_CAEEL 
ID   A0A2C9C3E8_CAEEL        Unreviewed;      5202 AA.
AC   A0A2C9C3E8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:SOF58806.1};
GN   Name=unc-68 {ECO:0000313|EMBL:SOF58806.1,
GN   ECO:0000313|WormBase:K11C4.5e};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:SOF58806.1}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5e};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:SOF58806.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:SOF58806.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:SOF58806.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; SOF58806.1; -; Genomic_DNA.
DR   WormBase; K11C4.5e; CE52078; WBGene00006801; unc-68.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   ExpressionAtlas; A0A2C9C3E8; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A2C9C3E8,
KW   ECO:0000213|PeptideAtlas:A0A2C9C3E8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4567   4590       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4753   4770       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4816   4838       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4954   4976       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4996   5021       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5081   5100       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1006   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1477   1696       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4313   4348       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4351   4383       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4326   4337       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4361   4372       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     1026   1046       {ECO:0000256|SAM:Coils}.
FT   COILED     4600   4622       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5202 AA;  590844 MW;  2311192F99B3153C CRC64;
     MADKEEQGGG EQDDVSFLRT GDIVCLSCVA SHNRDGVLGS ERVCLCTEGF GNRMCTLENV
     SDKDIPPDIA MCMLYIDNAL SMRALQEMMS ADSDHKSASG AGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQETNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMAYS KGYMVIASFH QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI
     PENWSEHPQH NMVIYEGGAA VTQARSLWRV ELIRMKWHGA LVGWEQVFRI KHITSGRYLG
     VLDNSVQLYH KEKADFDLTA FVMCQNKDPK KQMLDEKEEE GMGNATIRYG ETNAFIQHVK
     TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF MALEEESKSA RVIRKCSSVL
     NKFLKGIDAL QLEGNQSTDW TRVDLNEVLK LMEDLIEYFA QPNDEQDFEE KQNHLRALRS
     RQDLFQEEGV LNMILDTIDK FSQMEALPDF AGLIGEETHV KWEQISTYLY LLVAAMIKGN
     HYNCAQFASA QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
     KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV SSMMPNVMLG
     VVEGSALFRK WYFEAEVEHI ETMTKQTPYL RIGWANSVGF KPFPGSGDKM GCNGVGDDFY
     SYGFDGKSMY FGGKSRRVGH KLLEKGDVIG CSIDLTIPEI KFSVNGTYMS GSFKKFNIDG
     YFFPVMSLSA KVSCRFILGG NQGRLRYGPP TGFSAVVEAV NGELQITDCL SFGDLGKNIF
     SGPQTIFNNL EPFIPTPIDV SATQLNHHAT EMHQKYAENL HELWAMRKIE LGWSYGETRS
     ETSRKHPCLT KFEYLPETEK KYNILLALTT MKTIEALGYH LITEDPPCRL RAVRLGPNFQ
     QQNGYKPGPL DTHEIQLPAE LQPLTEALAR NTHNIWAKEK IKRGWTFGLS EHVDATQKRS
     PHLVPYEQVD ERIKQANRES AAENIRALQL FGIFLEPPAH EHDEVAEKEL RARKDNTRTY
     RAEATYAVCG GKWYFEFEIL TAGYMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG
     AETYGKEWKI GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
     SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKQLPRF EDISTLKSGS
     ILEVSRIPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIK LSLPVKCNDT FVKNKDKETI
     RRQLQEYKPR SQSVVSQIRA PGIPKEFDDN KEKKGFLRSM LGSKDSHESD DDRRSRTNSK
     QPSVDGDEPP AVRRSLLELP HDERQIAEDS MRDLNDRHSE KPKKGGLLSR LRDSSNTRKN
     FRDSDRRKEE KAAQLRQMKA NSRSFDAGSL DTSTLPTGQK DVLASSEMPL SGPGRQLTIK
     RSSIKKNKKG KKAEIALEKM EREKKGSIIP MDAQLDVLQE GDAHALVHHK DKVDEYYYGI
     RIFPGQDPSQ VWVGWVTTQY HYYNVNFDGS QGVRKCRFSE ADHHGTTVDS VQSQNCYMVN
     VSELLATTPD VANTKVSGTL IGCIIDTSIG ELSFQVGSTD TGIKFKLEPG AMLFPAAFVT
     PTATEILQFE LGRIKYTFPL SAAMFKSCEK SLVPFCPPRL TVEQIESVYW ARVPNETLRT
     TALKLSEVRG WSVLCNDPVR IMSVYIPEKD QSLDILEMIE MPDMLEFHRQ TLNLYCKLAS
     HGNHKVAHTL CQHIDEDQIM YAIKSHYLSG PMRQGFHDLL IGLHLMSHTA ARNSMAKEYV
     IPLVPQLQIK NVLDPDSESR YPQITGESVS MLSQMASEPV KKHVSREDEM KLLPPSVDFE
     ALKKHVMESL QSATHHAVMN CRDLIGGDNT NHFEPLFKLF DQLLVIGLIN DEELECLLRL
     IHPQAFDENY ETGTTQKGLT QLELAEPVKI QLVSILDHLC DIQLRYRIES LVAFTEGFVG
     ELQSDQCKRY MEIKQTDMPP AEAAKKTKEF RCPPKEQMFR LLMCKVKEER DPELMEEDAD
     VDQCPMAEGL QQQLRDFCEL LVGKIGNVKE GDSDDQLALI ESEEGSWVDS FARIVVKVPP
     PVLEEGMEMQ KKGTQNFREI IVTMLREWAQ ADFIESKSLI RNMFRLLLRQ YSGIREIRDA
     MSQTYVFHER NEKDVTDFLV YLIQIRELLT VQFEHTEEAI LKRGLWKLMN NRIFFQHPDL
     MRLLSVHENV MSIMMNILTA QQGTVEHEGD ELKEKAPIKD ASEMVVACSR FLCYFCRTSR
     QNQKAMFEHL SFLLDNATML LARPSLRGSV PLDVAYSSFM DNNELALALK EEELDKVAVY
     LSRCGLQPNS ELITKGYPDI GWDPVEGERY IDFLRFCVWI NGENVEENAN LVIRLLIRRP
     ECLGVALKGE GQGLFSAFKE AIALSEDIRL LENDSHPSLL SSGLLGENPT YPSKDAEGED
     YIDLGAATLD FYSSLVDLLA KCAPDPMAIQ AGKGDSLRAR AILRSLISLD DLGQILALRF
     TIPNLAAPSI EAVRRANAVQ ASHTQKAVMA HTFAMVASLA SEVSNTRRSQ TFTSGTNLAK
     RGLPCVEEVD TDDSKSSDYA SVHTSFSSGN ELFAPKAEKE KVDVLKLNEN KYPIIQRRRS
     SRFNPIDNTG PLPGLLPNHK GSVLLFLDRV YGIDQQDMLF HVLEQSFLPD LRAATMMDSP
     RALESDTALA LNRYLCNSVL PLLTNHSHFF ADAEHHSALL DATLHTVYRM NRLKSLTKNQ
     RDAVSDFLVA ITRELPPAMM IKLLKKVITD ILTMNDMNVL VPLRLITLHY ERCGKYYGSG
     NHYGVASEQE KRLSMLLFDA IFDTLGSRPY DPELFGKALP CMTAIGSAIS PDYTLTSGLE
     DVRNKRREEE GAWIPRTVDV SRCEINRDLE KMTELFAEHF HDSWASRKLE KGWVHGDLYS
     RANFTHPRLK PFALLKDFEK SFYKERCSEC LKALMAWNYS FEMMDRDAND RASAARTLSG
     TSISNFAPKP IDLSSMTLEK DMVNAAEKMA EHSHLIWAKK VMNDLNTKGG FMPIPLVPWD
     LLTDFERRKD RFRASEILKF LQYHGYHVNC PKDEQSQNDR LKSEGERTSV EKRFAYNLLE
     KLITYLEQAS LKMKSVKPSQ ELTRRNSFKK EGQDVKFFEK VVLPLMHAYF NAHKNYFLEG
     SSIVQTGTAS NKEKEMVANL FCRLAALLRI KNRAFGSVAK ITVKCLQGLT QALDLRTLVK
     VNSDIVRTSL LTFFNNCADD LYASVNELKD GGQYSLIRGQ ALKSWNSFEF ANQMIVPVLT
     TMFAHLARNH FGTDLLLDDI QAACYKILDS LYMVTGLSSS ISHRKSISGE SEKHRPGLGQ
     CLAAFASCFP VAFLEPEFNK SNKFSVLAKS QDQSVQVQEM LQNLSTHIPH LEKLLTDLET
     VANNNTMYSD VPNVYDVDLP LMCSYMAHWF SVGPDGKRDK EDQRASVVQT TSVSCDHINR
     IFNALLKMIR NHVGIENAPW LCRVNFFAVQ IIQNVTSDPV REFVLPIAER LRRMSEKAYK
     EEEHMRTHPD DADEGTVAED NARLVRDTYA FFPILMKYTD LHRAQWLKTP TWETDGVYEN
     VAVIFRIWSQ SQHFKREELN YVAQFEEDAA ATGGGDMKTG KAAIAERKKK RREGQDKMKE
     YFDRNGRPII KKDKHAASIV IACLKRLLPV GLNVFGGREL DIVQQSKEKF IQKETEEKIR
     EFIKGLLEIP VKTDPTDKNA WQLSLYRKIG KSQMRGKDEM SQDAVIEKIF NMGQVSAILH
     TTEHPQMQLS QAWKKVVSTQ RKRAVVACFR MVPLYGIPRH RGINFFLPAF SRLWMEEEDA
     GQDQLIADIC SGVEEEEGPR IEIIMEEGVP IVASSEDTKE KETNPDPLKQ LIRCFQRAAT
     SEETAASAIH EDSLYIRFAD VMAKSIHIEE EDGEDGEEGE IDQAAKEEQS QALRGEQAVL
     ASRGAAIMCL MYLSASGGEP NEMVAQTLQL GIHLLSGGNV EIQKMLIEYL QLKKDVRFFT
     SMAGLMNKCS VLNLEMFERQ IKAEGLGMGA ELASGDNQNL NDADFTCSLF RFLQLTCEGH
     NLEFQNYLRT QPGHTTSVNL INCTVDYLLR LQESVMDFYW HYSSKEVIDE GGKEYFLRAI
     QVCSQVFNTL TESIQGPCVG NQMTLANSRL WDAINGFFFL FAHMMEKLYK NSTQLELLRE
     FLNLQKDMIV LMLSMLEGNV LNGSIGKQMV DALVESQPSV EKILKFSDMF LKLKDLTTSQ
     AFQDFDTNQD GWISPKEFQR AMESQKMYTV EDITYLMMCT DVNNDGKVDY MEFTERFHNP
     ARDIGFNLAV LLVNLKEHIT NDPRLEKIIE KAQTLLEYFD PFLGRIEIMG SSKRVEKIYF
     EIQESWLEQW GKQQIRDSKN SFLFNVLQDD GGDQGKLEAF INFCEDTIFE MQHAAAISSG
     DSDTKMERAI KQRDYFLQQT SADHISETFK SGYNYGISAA SALSPQNIST TMRNVSSSVR
     QMSWTQLLYA VIILFIRAGL AIGWAGYLLL MTIFRFGYFL TTSSEEEEAA RQEKEQAKMN
     NEHPSFNPPI IQEFHHSHVG VTAFGVGMNA DHLNVNSLPD FVPPERPETP ETVLEEEKPL
     NQETSPPTSP TSPASKAPSI YESIGAPQMV QLQSEADFQQ GQYEPKIAES NSTKSRGSIL
     NMLARNFKTI EKITLYLAFF INVILLFHRV DISHAENAEA ASEGDDDEDA LESIFITGMQ
     FPYVEYEITG WMLAQILYWI SVLHLSTSFA LLVSFYQLKI PLITFKREKE IARKLMFDGC
     WITEEDSEEL GIVDTFMWYL DRIVVSAKSF PMMYWDKFVR RKTRSKFKDQ VDEETLTSIL
     GEEKMSTDSS YDYRYSCWLW IGVILTNGQF LYRVGYLLCS ACGVFLSPFF YAFHLIDVVL
     SFPMLKAILQ SVTHNLQQLI LTIMMTLVVV YLYTVIAFNF FRKFYVQEGE EGEEPDRKCH
     NMLTCFIYHF YAGVRAGGGI GDELESPYGD DLEYPRMFYD ISFFFFVIII LLAIMQGLII
     DAFGELRDQQ ESATEKLESS CFICDIGKET FDRMPRGFEI HTTKEHNFAN YLFFLQHLVN
     KDETEYTGQE TYVREKYDNR DWDFFPVGEC FVKQYEDQLL QS
//
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