ID A0A2C9C3G0_CAEEL Unreviewed; 448 AA.
AC A0A2C9C3G0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Tyrosine-protein phosphatase vhp-1 {ECO:0000313|EMBL:SOF58747.1};
GN Name=vhp-1 {ECO:0000313|EMBL:SOF58747.1,
GN ECO:0000313|WormBase:F08B1.1g};
GN ORFNames=CELE_F08B1.1 {ECO:0000313|EMBL:SOF58747.1}, F08B1.1
GN {ECO:0000313|WormBase:F08B1.1g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:SOF58747.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:SOF58747.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:SOF58747.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; BX284602; SOF58747.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9C3G0; -.
DR SMR; A0A2C9C3G0; -.
DR EnsemblMetazoa; F08B1.1g.1; F08B1.1g.1; WBGene00006923.
DR AGR; WB:WBGene00006923; -.
DR WormBase; F08B1.1g; CE52069; WBGene00006923; vhp-1.
DR OrthoDB; 2879982at2759; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00006923; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; A0A2C9C3G0; baseline and differential.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF540; TYROSINE-PROTEIN PHOSPHATASE VHP-1; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Proteomics identification {ECO:0007829|EPD:A0A2C9C3G0,
KW ECO:0007829|PeptideAtlas:A0A2C9C3G0};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 1..109
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 29..90
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 144..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 47587 MW; AB96F390AAEE5309 CRC64;
MTCPKSVCIK EDKNFMRIPV NDSYQEKLSP YFPMAYEFLE KCRRAGKKCL IHCLAGISRS
PTLAISYIMR YMKMGSDDAY RYVKERRPSI SPNFNFMGQL LEYENVLIKD HVLDYNQASR
PHRHMDYYGP SDLCPPKVPK SASSNCVFPG STHDESSPSS PSVSEGSAAS EPETSSSAAS
SSSTASAPPS MPSTSEQGTS SGTVNVNGKR NMTMDLGLPH RPKALGLPSR IGTSVAELPS
PSTELSRLSF NGPEAIAPST PILNFTNPCF NSPIIPVASS SREVILTLPT PAASSSSSTS
SEPSFDFSSF ESSSSSSIVV ENPFFASTEV PAGSSSISTP SGSQSTPASA SSSAASRCRM
KGFFKVFSKK APASTSTPAS STPGTSRAAR PECLRSSGII ISAPVLAITE EEDAESPESG
FNEPEVGEED DDSVSICSTS SLEIPCHQ
//
