ID A0A2C9CN86_9RHOB Unreviewed; 1100 AA.
AC A0A2C9CN86;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=SAMN06273572_101526 {ECO:0000313|EMBL:SOH92678.1};
OS Monaibacterium marinum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Monaibacterium.
OX NCBI_TaxID=1690039 {ECO:0000313|EMBL:SOH92678.1, ECO:0000313|Proteomes:UP000220034};
RN [1] {ECO:0000313|EMBL:SOH92678.1, ECO:0000313|Proteomes:UP000220034}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7 {ECO:0000313|EMBL:SOH92678.1,
RC ECO:0000313|Proteomes:UP000220034};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; OCTN01000001; SOH92678.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9CN86; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000220034; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 3..468
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 489..766
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1100 AA; 119585 MW; 06FE28C919119CDA CRC64;
MTLSDASRAQ NRASSPAGSA WVGANAGSGK TRVLTDRVAR LLLHGADPQR ILCLTYTKAA
AAEMKNRLFK RLGAWSMMPD AELLEELAQL EETGEVDLGN ARQLFARALE TPGELKIQTI
HAFCGTILRR FPLEAGVSPS FREMDDRATL ALRTELLDQI AEVEPDIFAA MAVHCPGDGP
EGLINAILSQ RDAFATPFDP AALADELGVS LNGPPMQVMG PDERDLLSRL ADAMVAVGTA
NEKKNALPKV LNAMQAQGDE PVESLLLYGE KTDKRDHLAK VDKFATKKVM QALDPADVEE
LNELAMAVEA ARSDRLARAV LERTQALHDF ADVFLTRYDE AKAAQGMLDF DDLILRTRSL
LTRPDMSQWV LYKLDGGIEH ILVDEAQDTS PRQWDVVEAL TPEFYAGEGV ERRERTLFVV
GDEKQSIYSF QGAQPAEFGR MREVFRGRLG AADKPFGEVA LDVSFRSAAP ILSLTDEVFA
PTDRGGVSDE VIHAAFDDGK AGRVDLWPFL ETEKDGVEVP WWEPVDTPSP DRADLQLGRY
IAAEIARLIA GGTLIPSPDG PRPMTPGDIL ILLRSRGPLF HALIGNLKEA GVAVAGADRV
KLGGELAVKD LLALMRFAVT PDDDLSLAAA LRSPLFDVDE DALFRLAHGR GKSRLLGRLQ
DDPQHKAVAD FLQEVRDDSD FTRPFEFLDR ILTRRDGRRR FIARLGAPAA EGLDELLAQA
LNYERTEPPT LSGFLDWLEP DTLDIKRELG EGGDAVRVMT VHGAKGLEAP VVILPDTAHR
NRKAAPPVLP RDDAAPIWQA SPNSDVEAEA VAAHKARDDR ERERLLYVAL TRAEHWLIVA
GAGKRGSDAD PAWYDMVEQG MMDLSATTHT APDGLEGPLL RLESHWSGGT STAIVAEAAP
ALVALDWGHV APPVADRLLS PSGMDGAHAL PGEGEEAARA LLRGDVTHAL LDLLGQRDRA
AMAAPLLDRL PLDMQSDVFD EVCALLDTSE LSHLFGADAL SEVPVSGTVG GRAVFGRVDR
IVRDGDRILI VDFKTNRVVP DQPEDTPEAL LRQMAVYRAV LAPTFAGKQV DVAIVWTAAK
RMDVIPHEVV NGALLRAGLS
//
