ID A0A2C9F2C1_MOUSE Unreviewed; 611 AA.
AC A0A2C9F2C1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Synaptotagmin VII {ECO:0000313|Ensembl:ENSMUSP00000076234.5};
GN Name=Syt7 {ECO:0000313|Ensembl:ENSMUSP00000076234.5,
GN ECO:0000313|MGI:MGI:1859545};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000076234.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000076234.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076234.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000076234.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076234.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006527271.1; XM_006527208.3.
DR AlphaFoldDB; A0A2C9F2C1; -.
DR SMR; A0A2C9F2C1; -.
DR STRING; 10090.ENSMUSP00000153132; -.
DR PaxDb; 10090-ENSMUSP00000127973; -.
DR ProteomicsDB; 355845; -.
DR Antibodypedia; 2220; 287 antibodies from 33 providers.
DR Ensembl; ENSMUST00000076968.11; ENSMUSP00000076234.5; ENSMUSG00000024743.17.
DR AGR; MGI:1859545; -.
DR MGI; MGI:1859545; Syt7.
DR VEuPathDB; HostDB:ENSMUSG00000024743; -.
DR GeneTree; ENSGT00940000157180; -.
DR OrthoDB; 590187at2759; -.
DR ChiTaRS; Syt7; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000024743; Expressed in medial dorsal nucleus of thalamus and 185 other cell types or tissues.
DR ExpressionAtlas; A0A2C9F2C1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR CDD; cd08386; C2A_Synaptotagmin-7; 1.
DR CDD; cd08405; C2B_Synaptotagmin-7; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037732; C2A_Synaptotagmin-7.
DR InterPro; IPR037741; C2B_Synaptotagmin-7.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF344; SYNAPTOTAGMIN-7; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:A0A2C9F2C1,
KW ECO:0007829|PeptideAtlas:A0A2C9F2C1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 343..463
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 474..607
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 126..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 68297 MW; 86619203FEF431F7 CRC64;
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK NSLETVGTPD
SGRGRGEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL NISPYAPYGD PRLSLNFEDS
TLSTATTLES IPSSAGEPKC QRPRTLMRQQ SLQQPLSQNQ QGRQPSQPTT SQSLGQLQAH
AASAPGSNPR AYGRGQARQG TSAGSKYRAA GGRSRSNPGS WDHVVGQIRN RGLDMKSFLE
GRMVVLSLVL GLSEQDDFAN IPDLQNPGTQ QNQNAQGDKR LPAGGKAVNT APVPGQTPHD
ESDRRTETRS SVSDLVNSLT SEMLMLSPGS EEDEAHEGCS RENLGRIQFS VGYNFQESTL
TVKVMKAQEL PAKDFSGTSD PFVKIYLLPD KKHKLETKVK RKNLNPHWNE TFLFEGFPYE
KVVQRVLYLQ VLDYDRFSRN DPIGEVSIPL NKVDLTQMQT FWKDLKPCSD GSGSRGELLL
SLCYNPSANS IIVNIIKARN LKAMDIGGTS DPYVKVWLMY KDKRVEKKKT VTKKRNLNPI
FNESFAFDIP TEKLRETTII ITVMDKDKLS RNDVIGKIYL SWKSGPGEVK HWKDMIARPR
QPVAQWHQLK A
//