ID   A0A2C9GPI2_ANOAR        Unreviewed;      2316 AA.
AC   A0A2C9GPI2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   28-JUN-2023, entry version 20.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA016649-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA016649-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA016649-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
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DR   EMBL; APCN01001728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; AARA016649-RA; AARA016649-PA; AARA016649.
DR   VEuPathDB; VectorBase:AARA016649; -.
DR   VEuPathDB; VectorBase:AARA21_010325; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   CDD; cd13275; PH_M-RIP; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039597; M-RIP_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR17271; PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR17271:SF1; PROTEIN OUTSPREAD; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
FT   DOMAIN          1..94
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          376..474
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   2316 AA;  256345 MW;  C2AAFA63AB8F9923 CRC64;
     MCVFLSLSFP QRWQRRWFVL YDDGELTYSV DEHPETIPQA IIDMTKVLEV TTADNITSHP
     HSIAITAPDR VTFVKGTCPE ESKWWFNVLV AFPKSKGRHK RNATFPGGQA TTILQAQMYN
     EVQSPISTKS NTPPGRDKLT LQLDGGKAQP RLRTRHRSSV DVSDSAAKCL LLDGGVGISG
     TELRSRDEPK LKDIANTITN VNRWSSPCIT DSLSLTAADH HNHHQPTSPR DENTIPPQYT
     NGTNGGVGGG GGGTGGGSTG GTGGTPASVG GGGTPLQMRP HSLTLPSSAP AIVSAIVKKI
     PTSLTGKGST GCPVPPLGAL HLPPPSTTTT NATSPKLKPS QTHERGDPDG DCGADDAPAS
     YLGKNSEHRG PDADLLHAKK GWLLKQDGRA GDWSKHWFTL RGAALFYYRD PVAEEKGVLD
     GVLDVNSITG IAEVLVNKGY GFQLTTWDNH RIVLSAVTIN VRNNWINVLK NAAGLPPTKA
     TLELSNQNDD NFKTLADKSP PPSPATPSSL EISELLGDAI EHKPKLKRGK LLEKNNNNSG
     TNGHLLIEGV VPLAASPTAG EDVVDKAPKD VIVHLTAARH LTEQSNSAST PPEDKSAMNA
     STTTNTNTNT TTNTTNTSTH SSSNSSSTSS SQPQPKQQSS VVVLQSPVTP LTPKSLLFSS
     DEEYRTASEG GRRDSVGDQW GSPVSPSPPS VVPLAMRTKD RLRTNPPLSA QSQQQQHQRL
     HKRSRSSPPS SRRSTIESEA PVPLAPFHTV QEEDGSGLEK ELQLRLQAAE KELAMLREET
     HEREARMSEL LTTLERTEQE LTRKRELEEN REKLMVQLQD SRAAGQDIID RITHELSKSR
     DTTKELEERL ARGIEENESL YRRLQECGIA APGTSPASSL CSLAVARSGR IKRMDSFSDL
     TCLTAIDPTQ LDRDMLADEY RELRARFERA VSELKAMKRE LKDAHGLYDE LEIAYATLRK
     ELDRQATEHE AQSRMMAVRI QDMTNKYTAA EKQVRLLKQK AIRSEKRRSL SLKGKESLSI
     QKELEEKVSE LESKIDALES GGVLLPVAKA TVELATPEAA QPVRRSSSTR LRRKSLDSAT
     LSAQPMQVVL RLNNLEKRVE NVQAVGLPVA KPPEVSECET ASTSSTGAKP VPEHLLDRLK
     SLEGVVVSVR ELIDQSAQQF QSLRTSRSRR SVSPAADRKD SYKFIERCLA EVSKLLRESC
     DNCVVPVEGT GYGSVIVLPE SNPIKLALDQ LEAQLKGKLA DLLKQRRMLR ETNGLTQRKD
     MELLAERIAF ESVCFGRLRH ALERAENLAE FEERQTKVEV CETVQLMSML KAKLSGKCVV
     RPSSSADVLA SVLARKLMLS AGRTSTMRSL SFPPIGTALL DDLLRQQNEV HLIAKRYQTT
     IMENLAYGLA AETLSYIASS HETVQGAVQE AWRQAQEAVN AELVQSEIAH IMMRNAQRYE
     GSLAPAFGYA LSTQERITFE TFADAVHEAL RREMDAAVRQ LTECYEETLA KMKRGQWRLH
     LEQERKPSEG RQLLAEFADI VAHKALIDAR VHVLKGDYVP KKPAQSTDAL DEPCERVFSV
     AALKQYENLY TDLTADLEVA NADDILAEAD FNFMYKYFTS EHALNKAEVK EVSAILNELE
     RSVVALQATL HPDSGNAGAA SAIDVDSLRS IHARCVEIQQ RIDSLISAAK QLQSRSDQCG
     RLQDRLLQLT EEHERELGTI RQQHEAKLAA LQRRIDEQQQ RIRAIDGERA ELLERLNNER
     NLLKQKEKEL HELSVRLTRL DAASNEKDKE IEDLLDSYDQ ECKKARTLKD RCEELAGSCR
     KTAAEYAELE KERDYLYEQM RKEQDHAKKL EKHLEMVEAE HAQQVDNLHA AYREQQMANE
     LDSQKDRDDE DSLRSRYQAE IEQLRALCEK GLAAMEASHK RIIHDLEEKH QQEIAKLILE
     KEQALAEETQ ATLAALDAMK KAHQNEVQRE VTRFKQEFLK QFQKGGQPPQ TYREKEQELE
     EVRLEILSLS EKYSMKCVET AALEEKLRNA TQQLKCSQQH IQQLDVRNKQ LRAHFVSNQP
     EETSSAPPTS SVVTPKDTNL FTSNSTLQQH LESSPPRSTS ALRTATGHGS PTTPTPTTPT
     TIVPSSVPIE PTSAPPPLEL LDLRECQHLL NNNKKESHPR TTVGTSAPGT AIVNDSVNLA
     SSTNNNRAKV LSSKQLNMNL ISGGSGPLSP TGPPTPHPVA LTLPLIASAT FKHSNLHRNH
     QTAIANNAPA CAGNGSSNHN NNNNNTNLLI NLNNNHIHSN NNNNVSNLNN NNNNNNNNNN
     DNDSMHELKP STKLCSPPPL DERDVEQQIH RFELEI
//