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Database: UniProt
Entry: A0A2C9GSU1_9DIPT
LinkDB: A0A2C9GSU1_9DIPT
Original site: A0A2C9GSU1_9DIPT 
ID   A0A2C9GSU1_9DIPT        Unreviewed;       453 AA.
AC   A0A2C9GSU1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Heparan-sulfate 6-O-sulfotransferase {ECO:0000256|RuleBase:RU364122};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU364122};
OS   Anopheles atroparvus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=41427 {ECO:0000313|EnsemblMetazoa:AATE021892-PA.1, ECO:0000313|Proteomes:UP000075880};
RN   [1] {ECO:0000313|EnsemblMetazoa:AATE021892-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=EBRO {ECO:0000313|EnsemblMetazoa:AATE021892-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate
CC       from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the
CC       N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
CC       {ECO:0000256|RuleBase:RU364122}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan
CC         sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) +
CC         adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:56604, Rhea:RHEA-
CC         COMP:9830, Rhea:RHEA-COMP:14621, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388,
CC         ChEBI:CHEBI:140604; Evidence={ECO:0000256|RuleBase:RU364122};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364122}; Single-
CC       pass type II membrane protein {ECO:0000256|RuleBase:RU364122}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 6 family.
CC       {ECO:0000256|ARBA:ARBA00010109, ECO:0000256|RuleBase:RU364122}.
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DR   AlphaFoldDB; A0A2C9GSU1; -.
DR   STRING; 41427.A0A2C9GSU1; -.
DR   EnsemblMetazoa; AATE021892-RA; AATE021892-PA.1; AATE021892.
DR   VEuPathDB; VectorBase:AATE021892; -.
DR   OrthoDB; 2896660at2759; -.
DR   Proteomes; UP000075880; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR010635; Heparan_SO4-6-sulfoTrfase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005331; Sulfotransferase.
DR   PANTHER; PTHR12812; HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3; 1.
DR   PANTHER; PTHR12812:SF0; HEPARAN-SULFATE 6-O-SULFOTRANSFERASE; 1.
DR   Pfam; PF03567; Sulfotransfer_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU364122};
KW   Signal-anchor {ECO:0000256|RuleBase:RU364122};
KW   Transferase {ECO:0000256|RuleBase:RU364122};
KW   Transmembrane {ECO:0000256|RuleBase:RU364122};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364122}.
FT   TRANSMEM        45..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364122"
SQ   SEQUENCE   453 AA;  51623 MW;  BFE8ABC9B1065F33 CRC64;
     MKKVMIPSLD MKKSISVKVD SDLTLLLSSG VYEIKKMEPR RRLRPIAIVC LFLTIAGIVG
     FGYFCPDQVC ALSRREPVGL GGGPMASTGL ELAGGGGGSY EHDNLGKPVQ QNLLANPGLS
     YEEVLNDDFQ FDMNAHDVMV FLHIQKTGGT SFGKHLVRDL DLKRPCTCQR KKKRCYCFRP
     HRNENWLFSR YSTGWKCGLH ADWTELTGCV DQELDKNEGE TAKRRYFYIT LLREPIARYL
     SEFRHVQRGA TWKNARHWCL GRHATPDELP PCYNGANWNG VALDEFAGCE SNLAANRQTR
     MLADLALVGC YNKTYMPTAE RDRIMLASAK RNLAAMSYFG LTEYQKISQY IFEETFNLRF
     AIPFEQHNTT VSTVTMHGLT PAQRARIDKL NALDIELYAF AKKLMFQRFE RLKAKDNDFE
     VRFAHLGNLG VRNGVTEFNW DSNIDDMPSN EHH
//
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