ID A0A2C9GUU7_9DIPT Unreviewed; 557 AA.
AC A0A2C9GUU7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR005012-PB, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR005012-PB}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR005012-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2C9GUU7; -.
DR STRING; 7168.A0A2C9GUU7; -.
DR EnsemblMetazoa; ADIR005012-RB; ADIR005012-PB; ADIR005012.
DR VEuPathDB; VectorBase:ADIR005012; -.
DR OrthoDB; 5491001at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 6.20.40.10; -; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF342; SERINE PROTEASE INHIBITOR 28DC; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 2.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..557
FT /note="Serpin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012361250"
FT DOMAIN 64..556
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT REGION 37..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 62816 MW; F59E3051C9795305 CRC64;
MHSGSRVPWM LAAVLLATVL VAGPVAGQKN FAQKQAQVTQ QTNRQQPQST NTKKVSDSVT
NLAQRIAGAI ANQKSKTEIF SPVSIAGALS LLLLGSGGKT QTELLNVMGL NPQELSFRDI
HLSFGRLFQD LVSNEPSLEP LVTWRLNDKC NRLDDEDDYE DEPNAEAPNK QNETDLVMQI
GNGIFAQNGT SFDPRYDKLA KDLYKSELQQ LDFVSDESHS VRVINNWVHN QTHGRISDIV
SHISPDTILM IINTLYFRGL WEEPFQPLAT RNRRFYPNGP DGPDSFDVQT MAKSHCMPYY
FWEEMNVRVV GVPYRQNVTM YIFLPTNSTR ELVQKLQKNI SAEKVNEIVT KMKMKSVTLL
FPKMHISNSL SLKSVMQQLG LYSVFDRHQA DLYSLLHGTP SKQDLASKVG EMEAGDIFDL
LEDTTENAIS ELKKHDPDCT IQYREGILRG ECLKSGCAFG GNKCVCCSEV AQDFRRRRRD
IKVNMKPANE TIFVNEMLHK VDLSVNERGT EGGAATATLI DRISSQINFI VNGPFFMFIR
EETTRLPLFY GNVYNPK
//
