ID A0A2C9GVC7_9DIPT Unreviewed; 653 AA.
AC A0A2C9GVC7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI001360-PB, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI001360-PB}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI001360-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A2C9GVC7; -.
DR STRING; 199890.A0A2C9GVC7; -.
DR EnsemblMetazoa; AEPI001360-RB; AEPI001360-PB; AEPI001360.
DR VEuPathDB; VectorBase:AEPI001360; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07887; RHD-n_Dorsal_Dif; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR011363; Dif.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF20; DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PIRSF; PIRSF001716; Dorsal; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
FT DOMAIN 6..186
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 309..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 70778 MW; BFE12BFDADF602D8 CRC64;
MPPVPNQRPY VEITEQPHPK ALRFRYECEG RSAGSIPGVS TTAEHKTFPS IQVHGYRGRA
VVVVSCVTKE GPDHKPHPHN LVGKEGCKKG VCTVEINSTT MSYTFNNLGI QCVKKKDVEE
ALRLRQEIRV DPYRTGFAHA KEPGSIDLNA VRLCFQVFLE GQQRGRFTEP LTPVVSDIIY
DKKAMSDLII CRLSDCTAPV TGGKEIILLC EKVVKEDIKV RFFEKKGNVT VWENYAEFSH
TDVHKQVAIC FRTPPYKSID ISEPVRVYVQ LERQSDNTYS DARDFQFIPL DSVELRRKRQ
KLASSSNVFM PVAPPLSGPP PQSSAGMPGN IPNLSQLDAT GGASTSGLPR GIYNYHGTSP
FQQMPKEEIK NEPGDSPIHN PSNQYQLQPV QGMLTTQSTS PGPDRSPAGT LTPSPGIGGP
ISPLDPGNVT PTPSPYTTLG GNGAASGATV GNLFGPFGTG FGNTTNAPQP QNAAVSMFET
NLPGPSNGWV QPIPLHLQNG NPSQQQSFNL GNFGSLPLPG DPILTMGTAN PLPATTQPTG
GPPSMGSDFN FMNLDLANLD PVFNSSELRS VLGALSTTEL NRLDQAANMQ TSGSYQQTSA
SNHQQTIKAF LAQSQQQQQQ QQAQGQGQTL PDRNDNDEDL TDSFTKLSTN DLN
//
