ID A0A2C9H890_ANOQN Unreviewed; 921 AA.
AC A0A2C9H890;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA016708-PB, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA016708-PB}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA016708-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A2C9H890; -.
DR STRING; 34691.A0A2C9H890; -.
DR EnsemblMetazoa; AQUA016708-RB; AQUA016708-PB; AQUA016708.
DR VEuPathDB; VectorBase:AQUA016708; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07887; RHD-n_Dorsal_Dif; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF20; DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 6..186
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 382..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 452..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 644..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 101341 MW; 715E2C86079B6C25 CRC64;
MPPVPNQRPY VEITEQPHPK ALRFRYECEG RSAGSIPGVN TTAEHKTFPS IQVHGYRGRA
VVVVSCVTKE GPEHKPHPHN LVGKEGCKKG VCTVEINSTT MSYTFNNLGI QCVKKKDVEE
ALRLRQEIRV DPFRTGFGHA KEPGSIDLNA VRLCFQVFLE GQQRGRFTEP LTPVVSDIIY
DKKAMSDLII CRLSDCTAPV SGGKEIILLC EKVVKEDIKV RFFEKKGNAT VWENYAEFSH
TDVHKQVAIS FRTPPYRTID ISDPVRVYVQ LERPSDNTYS EARDFQFIPL DTGRRRFSAL
HRELMKNPSS DTPENQLFKR ILLEGSNRSA LEQQIKPTNG FAPQRTEQVE VIVLDTPNVE
DKPFVAEAVT SDQKTTEWIQ RNEFNDGGSG SGDDNQMVTG DTNNNVFQPN SFDLPDGTNN
QVDENANGMV PVATAAAATT GSAAVPDDDQ TLKELLEQVA ELDEIYTDHQ LRRENLMLEQ
ELKQLEQTVP VQLGSPGGQP MDIDEVFDDA ATYTSLQRAF KNPLSITLGP PIPPRPEHAK
LDAGVYDAVE PLHVPTIDVT SLKRDSQELE KLPPLPPKRA KPSVQNKENN ALDANDEVLL
NTIIRKGSMR SLAPRPQSDQ IIIMKTPDSP LNKKLPPTPP TSPTKSSSGG NGASDCSTLP
KNGAKKPGFF SKLFSRKKSK SDLTASTNTL NRKNTPGGSK EPSLCVDLEG KEGQSTHRKG
SLRDSSGEKR KTGKPVARSV SSVSARRPAS DANCPDYIYI PLKGDGPTGG MQSRNGGSGT
HLSLPGNDSY ERASTASLPP LDRKAVSALQ LDVPIQDGNL ELVAIADARS IKNLVEGNYG
VQLDPNVDLT EAEHFALYTS IAPNAALSEF DETSCYYAPV EPNPLASSSQ QYPLNQQQQQ
QQQQQQFQQS QLTRMVTDSD V
//
