ID A0A2C9JC35_BIOGL Unreviewed; 1326 AA.
AC A0A2C9JC35;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN Name=106074327 {ECO:0000313|EnsemblMetazoa:BGLB000218-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB000218-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB000218-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB000218-PC};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- FUNCTION: Hemocyanins are copper-containing oxygen carriers occurring
CC freely dissolved in the hemolymph of many mollusks and arthropods.
CC {ECO:0000256|ARBA:ARBA00002958}.
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DR RefSeq; XP_013090530.1; XM_013235076.1.
DR EnsemblMetazoa; BGLB000218-RC; BGLB000218-PC; BGLB000218.
DR VEuPathDB; VectorBase:BGLB000218; -.
DR OrthoDB; 2945966at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.2570; -; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 3.
DR Gene3D; 2.60.310.10; Haemocyanin C-terminal domain; 3.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR028999; Haemocyanin_beta-sandwich.
DR InterPro; IPR036848; Haemocyanin_C_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF14830; Haemocyan_bet_s; 3.
DR Pfam; PF00264; Tyrosinase; 3.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF81277; C-terminal domain of mollusc hemocyanin; 3.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 3.
DR PROSITE; PS00497; TYROSINASE_1; 2.
DR PROSITE; PS00498; TYROSINASE_2; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1326
FT /note="Tyrosinase copper-binding domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012338493"
FT DOMAIN 78..95
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 214..225
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT DOMAIN 635..646
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT DOMAIN 903..920
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
SQ SEQUENCE 1326 AA; 151204 MW; D70CC410C454E400 CRC64;
MGTSRVLVLT TLVYLCRGLI LRKDIDSLTS EDTINLRLSL QGVKYEYQLK KSYSYIASFY
GYPTRCSVGN VAYSCSVHGM PTFPQWHRLY LAHLEQALTE KGGTVGIPYW DWSKPLQKMP
AFLDDEKYNL EGEILDNPWH HTNISLSGVI HATNRTVDSR LWSLDLMEHI IHALEYPNYC
QFVVQLEVLH SAIHFLVGGA SKYSMSNIDF AAYDPLFLVH HANLDRIYEV YEALYRERGS
VPGTSCETDC EICDIKGFQM PLEPFNRDDN PFPNTRLLAT GWNMTDKTVF DYNYDSLTLN
GLGIADIKKR IEMKKKTDRA FAVFKLNGIQ RSVNLRIQVC KTSSEDEEDT CESAGDVFIL
GGSTEHPWMF RRPYYHDITK AVLKLGLKLD ENFRVLTEMY GTDDKINSSE ISPQPSVEFR
PAVGKQDAPL SEKKKDVIIR QDVDLLTEDE MNALRVAMEN VQNNGTQNGY QAIAAFHGAP
GQCPTPNPDV ALTYSCSIRG LPSFPHWHRL FVMQLEDSLG LSTGIPYWDW TKPGVQLPNL
VKDATYQIKD GDSPKANPFY DAAIEFLRTG SRTSRSWPEQ GVNLDDLKDA VLLALEQDNF
CDFEVQFEIA HNLIHALVGG NAPYGMSSLE YSAYDPIFYI HHSFLDKIWS IWMSLQELRG
KPYKAHCAQS YIFTPLSPFN FSTTYNPNPK TYAHSTATNI YDHEKELGYT YDTLTFDGMN
ITELEHFIRF NVTSRPRMFV GVLLNGFNKS AKAEIHATLH TGERYIVGRF AVLGGPTELG
WRLDRLYKVD ITKAMFDAHL SWNDLFELSI EMFEFNGVSI ETDLPLLQLI YQAPEDSEIE
TQPALLRKNI QELTDGESNN LRDALKKLQS ETSADNFENI AGFHGAPNRC PPHGSDRFAC
SPHGLPIFPH WHRLLTVQFE QALSRLGASW GIPYWDWTDE STALPKLFSD PEDNPFYRYY
IQAEKEWTDR EVNLKQLNLL DPEGTKMLFH SALSILEEDQ FCDFAVQFEL LHYRLHALMG
GTKKYSLATL DFSAFDPLFM ILQSSFDRLW TMWQQLQYLR QKTVSGQCVY KHVDSSMEPF
RNPDINVNKM TRENSLPGLV SDHRRLGYKF DKLNLNVFSL KDLEDKIKLQ KSKNRTYAGL
MLRGVKNSVT LEVYLQDNQV GTVNILGGPN EKPWVFERPY KIDVTDAMKG AQLTTDKPVK
LHLKTGTYDG SSSSEKDMEV FIIERPSGSH HDILVVPINK KNPPPALKVV VKKDTQVKFV
TDDVVVPMKD FNTFTAWKAC NLPPSLQGSY DFGAVNPLIP GNYYMSPADV DLCNRGIKIH
IFVEEE
//
