ID   A0A2C9JCF8_BIOGL        Unreviewed;      1068 AA.
AC   A0A2C9JCF8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN   Name=106077114 {ECO:0000313|EnsemblMetazoa:BGLB000574-PB};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB000574-PB, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB000574-PB}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB000574-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_013093346.1; XM_013237892.1.
DR   AlphaFoldDB; A0A2C9JCF8; -.
DR   STRING; 6526.A0A2C9JCF8; -.
DR   EnsemblMetazoa; BGLB000574-RB; BGLB000574-PB; BGLB000574.
DR   GeneID; 106077114; -.
DR   KEGG; bgt:106077114; -.
DR   VEuPathDB; VectorBase:BGLB000574; -.
DR   OrthoDB; 354414at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 2.10.25.10; Laminin; 22.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR   Pfam; PF12662; cEGF; 6.
DR   Pfam; PF07645; EGF_CA; 6.
DR   Pfam; PF14670; FXa_inhibition; 6.
DR   SMART; SM00181; EGF; 21.
DR   SMART; SM00179; EGF_CA; 20.
DR   SUPFAM; SSF57196; EGF/Laminin; 6.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR   PROSITE; PS00010; ASX_HYDROXYL; 15.
DR   PROSITE; PS01186; EGF_2; 14.
DR   PROSITE; PS50026; EGF_3; 8.
DR   PROSITE; PS01187; EGF_CA; 7.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1029..1054
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..96
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          509..549
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          550..590
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          591..631
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          632..672
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          673..713
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          796..834
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          919..960
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        65..75
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1068 AA;  116228 MW;  E4E4269199D12645 CRC64;
     MGYQCSCYNG FMLAKQNGTC LDIDECLQPG QCSQNCTNTP GSYICSCFSG YAPDDNGICI
     DVDECVLAGI CQHNCTNSEG SYFCSCRSGY ALDANNYSCM DIDECKTNKR VCNQTCTNTL
     GSYSCSCNAG YMLGKDLTSC LDVDECAANG SLCSQICNNT SGSYYCSCYP DYILASDNRR
     CVYTDVCNAS TKECAYMCGG NSRQCYCYAG CEAAGVNITY VQVSECSVRT GLCDNLCKVS
     GGAYDCNCSS GYAFAADNET CVDVDECSLN TDKCSQICIN TNGSYFCLCD SGYYLSGDNI
     TCFKQDECMK TNLRCSQLCS NISGSFACAC RPGYVLAADN ATCLYLDICL ANTSICDQLC
     TTTVNGVFNC SCYAGCFGGN ESDSYMYIEH CSEMSGLCDH ACTAGNESYS CCSFGYYLAS
     DNFTCLDIDE CTLNKTICGQ VCNNINGSYY CSCNKGFALS RDNKTCVDID ECSIIPKVCS
     QNCTNVNGSY VCSCNNGYLL EKDNTTCLDI NECTATFNPC KHQCNNVNGS YYCSCQVGYI
     LESDKVTCLD QNECTSNQSD CEHFCNNTDG SYTCYCRSGY SLSANLHNCS DIDECARNVS
     HCSHMCNNTL GSYICSCQTG YRLASDNATC LDIDECANST NDCSQICNNT MGSYDCQCRD
     GYTLIPFNKT CKDIDECAMN ISRCEQICNN TEGSYTCRCR SGYNLSVDNI TCGDVDECVT
     NTSVCPDLCS NVIGSYVCRC PSGYILSADH STCLDVNECA ENTSKCDHLC NNTEGSFVCY
     CREGYRLAAD NLTCNDVDEC TENPSFCSGQ CTNTEGSFYC QCLAGYVLNN WTCEDVDECS
     VASTHNCSHF CNNTIGGFNC SCYGGYTLAP DKVTCNIKDP CFQVPSPCGQ NCTFANGTYK
     CSCREGYYLD PTDKATCRDI DECLGQNASF CEHKCVNLPG SFECSCRVGY ALSIDGHTCS
     KTVTYNKCPC SCKTASIKPL TSAEQLQQVI KEIVAIQKNL TVEKTGITAY ILTKQSANDD
     RTSTRSVGFV GLVIMVMVFV LIITPDLIMV MNIAKNYFKG DRKKSIKY
//