ID A0A2C9JFF1_BIOGL Unreviewed; 228 AA.
AC A0A2C9JFF1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN Name=106057231 {ECO:0000313|EnsemblMetazoa:BGLB001778-PC};
GN Synonyms=LOC106057231 {ECO:0000313|RefSeq:XP_013069804.1,
GN ECO:0000313|RefSeq:XP_013069811.1, ECO:0000313|RefSeq:XP_055876744.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB001778-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB001778-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB001778-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013069804.1, ECO:0000313|RefSeq:XP_013069811.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
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DR RefSeq; XP_013069804.1; XM_013214350.2.
DR RefSeq; XP_013069811.1; XM_013214357.2.
DR RefSeq; XP_055876744.1; XM_056020769.1.
DR STRING; 6526.A0A2C9JFF1; -.
DR EnsemblMetazoa; BGLB001778-RB; BGLB001778-PB; BGLB001778.
DR EnsemblMetazoa; BGLB001778-RC; BGLB001778-PC; BGLB001778.
DR GeneID; 106057231; -.
DR KEGG; bgt:106057231; -.
DR VEuPathDB; VectorBase:BGLB001778; -.
DR OrthoDB; 4342at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 2.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 28..224
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 228 AA; 24083 MW; E47F57E984290477 CRC64;
MVKKVLIILT SADKIPATGK PTGWYLPELA HPYKVLVDAG FTDIDAISPK GGKAPLDQSS
IDAFKDDSAC QWFLKDPKAQ SLVNNTKTPS QVKASDYAAV LYPGGHGPMF DLATDQAIGK
ISAQIYDNGG IVAAVCHGPA GLVPVTLANG TSIVKGKKVT CFTNSEEDAV DLSKYMPFML
ETRLVELGAT FSKADNWKEN VVVDGKLITG QNPASSASLG KALVSLLQ
//
