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Database: UniProt
Entry: A0A2C9JGC9_BIOGL
LinkDB: A0A2C9JGC9_BIOGL
Original site: A0A2C9JGC9_BIOGL 
ID   A0A2C9JGC9_BIOGL        Unreviewed;      2332 AA.
AC   A0A2C9JGC9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:BGLB002125-PB};
GN   Name=106055935 {ECO:0000313|VectorBase:BGLB002125-PB};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB002125-PB};
RN   [1] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB002125-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB002125-PB};
RX   PubMed=15562597; DOI=10.1645/GE-284R;
RA   DeJong R.J., Emery A.M., Adema C.M.;
RT   "The mitochondrial genome of Biomphalaria glabrata (Gastropoda:
RT   Basommatophora), intermediate host of Schistosoma mansoni.";
RL   J. Parasitol. 90:991-997(2004).
RN   [2] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB002125-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB002125-PB};
RA   Warren W., Wilson R.K., Hillier L.W., Minx P.;
RT   "Sequence assembly of the Biomphalaria glabrata genome version 4.3.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:BGLB002125-PB}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|VectorBase:BGLB002125-PB};
RG   VectorBase;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   RefSeq; XP_013067888.1; XM_013212434.1.
DR   GeneID; 106055935; -.
DR   VectorBase; BGLB002125-RB; BGLB002125-PB; BGLB002125.
DR   OrthoDB; 1337630at2759; -.
DR   Proteomes; UP000076420; Genome assembly.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.380; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000076420};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076420};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       35    216       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      446    619       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      662    756       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      930   1076       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN     1797   1991       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     2064   2235       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     2260   2325       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION        1     20       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      402    435       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      615    638       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1195   1221       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1627   1656       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1673   1700       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      509    529       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    402    421       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    621    636       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1205   1221       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1630   1656       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1673   1692       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   2332 AA;  262219 MW;  4BD7E2082FE762C8 CRC64;
     MAHSNTTGPR KGSRYHRLDD IPTDTFTPRT YQIQLLDSAL KRNSLLCLGC SESKFFLALM
     LAKELSSVTR LSLGAGGKRT FFLTDSEEDV DLLCQTLPNH TDLFINSCPM GLETENEKSF
     NDWRSLMQSN NILVCLGTKF LYAIQRNYIQ LKEVNLIIFD NCHKAVEVEN HPYAAIVQGI
     KKLTKSDRPH ILGVTAAIAG TDCNDPEKLT RTISSMEETM FAYAETSMLI LSERFGCRPK
     ESIIRCGDSE LYDDHSSLKD ILEDILEQCY FFFSDCRISI DDAVDNRNPC DTPLQVLNQC
     LNILNILGSW CTASVAEYFI MQLDKIIKFE KNDIHKQFLR CVITTLRYLV KTFEMNFHPN
     YDVNELLEYT TPKVRELVTV LRKYKPEMDF IIVSNSDSYN DDDEFSDISD DDDDSIMSGS
     DDEDSSGEGT KSKPMHIAVK RTADGGHERI MTFSEEEEKN LCGIVFVESR YIAFGLNKII
     EEVCSWDENL CFVKSCHITG QGLRGANGKQ KVNKTYKRQE EALRKFRTQE CNLVIATLEL
     EEGIDIPKCN LVVRFDPPKD FRAYALSKGR ARARDAVYVI LLDNDNFEGF NSSLKVFKGI
     EQVLLGENRS LSLTESLSSG EEADCEAEDD DEEMSESKDQ QLTPYYTMPN TPNSPHVTMQ
     SSIALINRYC AKLPSDAFTH LTPHCRIESV AGEPPLYIAY LRLPINSPIK EELQGPAMKT
     RKLAKMAVAL KMCEILHKKG ELDENLVPVG KEMFLYEEEE ECQNEEDMTG QARPGTTKRN
     NFILKRCAEV LLNCRPLPGE PSFLYLINLK LTGPITDEQN TRGRVIYAPE DTVQTLGILL
     SKKIPLMPYF PVYTRSGEVT VSIDLIQDII CSEEEILRLS KFHHFVFSGV LHLEKDPMDF
     DYVKADCGYL VVPLNGKSHN ELEIEWDFVD KVIDFIKIEK RAGFSSKGGS EPFHFNVDDF
     EDAVVMPSYR NIDQPQHFYV AEIRHDLNPV SPFPSPELYK TFQDYYTTKY GLMITNTVQP
     LLDVDHTSAR LNLLTPRYMN QKGVALPTSS AETKRARREN LQQKQILVPE LCDVHVFPAS
     LWRKTVCLPA ILYRANYLLL AEELRQKISR ETGIGLEGLP ERFRFPKLDF GFDTSPEKLL
     DHEGFSKKNS PNSKISKVEE ADVRLGHPRL KLENCELQAE NLKDHQIQPD EIAFTSEDTK
     TESSSDSDSG VASSSSSSDN CASKFYKCEA QTNLSLEQKS VDKNSSSPSV ESSITNYASD
     DITTSTTNSV SCNNQNSTFT KDGCDLSFTP ALQQSKSNSS TPAMSVISLS NHAPVTKCTS
     TISLATSLSP SVSPTFNVDI LKTNESTTYL SKDTKSCEMN QISLVADTST PGAYCQTGAN
     INATLFLPCS TLTTPPLFMS SSSVLSSSSL SSFCNIKDPS LVEEFSCSPM STKLVAGKMN
     PSDPSSSVSP NINAVLNVKN HLSNSKADLN IPGCEPQGPD AADPALFPAT ECIHDTLTTS
     LSNHCASQSP VAQSFNHNHI SPSNKAIRQE HDSAHTKNGY LLNGHAKHGN DSELSDGPSI
     IMNTLSEELS GLDIDLIIPQ TNTSDTFHTF DTPLQSDTKT NSQCGKKYGQ SSWQQAWLNE
     MEADLLEEEN QTDEKSVWNS EEKALTDKEK NSKNVPEESL LADNEVIKFS FDTQEVKTTQ
     DNSSSQDKNE LEKGNSVQVH TKSEEAPTNI TDFEIDYWNT ADKNTKKSGE NSLTKMYNKL
     IDQDEGIYDE LPSRPLYSKL KELKELSASH QQADAVATVS LDEDRDLTTF VGPSPCLIMQ
     ALTMSNANDF FSLERLETIG DSFLKYAITV YLYCSYPGIH EGKLSYLRSK QVSNYNLYRL
     GRRKGLAECM VSTKFEPFEN WLPPGYVIND DKRRGPVPKV VIVTPGSKVN NSLRNFYLDE
     ADTAKKDEAV LFNKELEWIQ QSQEADQQDE VQQEPSNNLT PYSLQCHHGL PDKSVADSVE
     ALIGCYLTTC GRTAALIFMS WLGLRVLPKK KKTIEDSNKL ERASGSSFCK LAELEFDELR
     CPPSPMFSNT EENQAKLQHL LQGFDSLEEK IGYTFRDKSY LLQAFTHASY HYNTITDCYQ
     RVEFLGDAIL DYVITRHLYE DSQKYSPGIL TDLRSALVNN NIFAALAVKW GFHKYFKAIS
     PSLFQVIDKF VKCQKEKKDD DIDIDEEFRE LSLEDCEQEE GADEEDEDEE VEMEIPKALG
     DIFESVAGAI YLDSGMSLDT VWRVYYRMMK PHIDKYLKSI PKSPVRELLE TEPETAKFER
     PERTMNGKVR VTVNVVGKGV FSGVGRNYRI AKSAAAKKAL RSIRTMAQNL LG
//
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