ID A0A2C9JIA7_BIOGL Unreviewed; 4165 AA.
AC A0A2C9JIA7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN Name=106056532 {ECO:0000313|EnsemblMetazoa:BGLB002959-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB002959-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB002959-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB002959-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_013068768.1; XM_013213314.1.
DR STRING; 6526.A0A2C9JIA7; -.
DR EnsemblMetazoa; BGLB002959-RB; BGLB002959-PB; BGLB002959.
DR KEGG; bgt:106056532; -.
DR VEuPathDB; VectorBase:BGLB002959; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017}; Membrane {ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4137..4161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1448..1586
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2106..2253
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 811..871
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2951..3013
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 186..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4165 AA; 479053 MW; 882F44903F45AE4E CRC64;
MPYKQFHRAS VSQPNEFELQ HRPPHINHLP PLSAPWPALS ETPKIVEQGS YTKAVPVKQK
KLVRGVSDCI GSNYSPRAAH LTTSHIYETT KQAYTTEETY FLSPRRSTVS LNSSNGHPSW
TSPLTKSNNS LGHSILVDAT SFRVISETKK TADSFIQPAP EDVIIKNGDS LLLEIKEEED
NDDQSHLNQG NGNLADNTPR TWSSVPMETV IEADFHEYSS DHDEEEEMKT LQETILVNVP
NHDNHTQECL DVKFPPWYFS THGLSRPSTP AEEERERYFL LAEKAIDPNM VGPITKETLE
GIYHFVPRSI RAKFPNASRA FLKEMDFDYR ASVRRAILDY ILLDQAEQQR LGLLLPLKPS
NLAGRDGFPW HENVQEARHI IEKNLFVTHP IMRIILYDFH VRFNDFRLID INDLKKLMPV
TMEEFLNHVK VSSSSAAETL QKVWLSDCCN LIDEMRDEIE AWMPVDTESR ITMMEHFFNS
VASLMSVLLR QIVEKSIQDL VSLIENYSEG NMYEGTYDIT TTIGLPNTLH PIKIFLKEDV
HNSTLQFSPS IPEICDFFCL IVDTIISSVQ KLSRIEQKLF QDVEDTRTIL SVEVEEEIVE
AAKDRIRSVM LANSHGPKKY KSVYETFKYL YTKETESQVQ HYVTGDHPLK EYRTVIEKLK
QMAWDIGSLP VYIPLHLFLL DCTHINQWLV DTARRFINTM VGKVTETNNK FDRQICFEYD
AIVKRCSYQA ENTRELVQLQ DYVESLKVVQ LLQLKTKLEI AAENLIFLME YAYLPKEDIN
LHNTTFTWPQ RIIPIINSTE SKLQREHDLA CNKLKEKKKQ FEILLSEYSK KVKDFGMKDR
MSESEKYVTE LEDIAMRIEE FQAKKVEINQ EEQMLDLDIQ TEYNQIDDIR ARKEPFEKLW
TTAVHFQQVH DKWMNGPFLE VNAEDVEEGV QTLWRTAYKL TKVFSHSDMK GPLRVSATIK
AKLEKFKINM PLITALCNPG IKQRHWDLMS QKTGFDITPK KDTPLQEVLQ LGLEKYLEEL
AGISSQASKE YALEKALKRM KDEWEVMQFT FVQYKDSGVN ILSSFDDILV LLEDHTVKTM
TMKGSPFIKP FEEEINKWDL LLHRMKSILD SWLRVQSAWL YLEPIFGSQD IRNQIPVEGK
MFEEVDGHWR DIMLKSVQNT KALVVVSQEA MLEKLQQSES KLDDIQRGLN DYLEKKRLFF
PRFFFLSNDE LLEILSETKD PLRVQPHLKK CFEGIACLTF DVNKVILAME SAEKERVNFT
MKIIPADAQG LVERWLQQVE QVMKMSLKEE MGKAVKAYSL TKRGEWVLQW PGQIVLAASQ
IHWTAEVTQA IRFGGLKAYL ARSNKQVEEI VEMVRGKLTK MARITLGALI VIDVHARDVI
SNLLHTTSPD DFSWISQLRY YFKDSVCNVQ MITTQVAYCY EYLGNTGRLV ITPLTDRCYR
TLMGALLLNL GGAPEGPAGT GKTETSKDLA KAVAKQCVVF NCSDGLDYKA MGKFFKGLAQ
SGAWACFDEF NRIELEVLSV IAQQVQTIQR AIMDKAGTFV FEGTEISLDP TCTIFITMNP
GYAGRAELPD NLKVSLIFNI YCKTDFTILG SICIICFQYN TLYFKSKGKN LYFTSFRIIK
AMKMCLGTEL ALLLIXXEIS LYSNGFVNSR SLALKIVATY RLCSEQLSSQ HHYDYGMRAV
KSVLTAAGNL KLKYPEQEED VLVLRSICDV NLPKFLSDDL ELFKGIISDL FPDISLPEPD
YRCLEEVLVE RIKETNLQCV PWFISKIIQI YEMIQVRHGL MIVGDPLGGK TSAFKTLASS
LGNLHRKGLM EENLVIYNII NPKAITMGQL YGRFDPVSHE WTDGLFNYLL ENLVLKFKLP
FIRCGMIYMD PSQLGWEPFI ASWLATELPS VLKKEQRDMI KLLFDWILPP CLNFVMKSCK
HILQLQQLHY VVCLLKMYSC LMEEVKKLGK DDEDDDNFVV GDMDKEETEA DSTIPVGASE
KKLEEERTNM LVAYFLFSVV WSLGSTLDND SRIKFDEFFR ELCDMEASKD KFPKPKDLKF
PRAVLIPKKG LIYDHIFVRK QFGSWSTWAS QVQSANIDDK TQVNSLIIST VETERQRYFL
KLFLPKDFPL LFVGPTGTGK SAITNSYLLE LPRDKYVINN INFSAQTTAN QTQDIIFSKL
ERRKKDIYGP TVGKKMCIFV DDLNMPAKEK YGAQPPIEIL RQWIDHGFWY DRKDTSKLRL
VDIVMVSAMA PPGGGRNTVT PRFLRHFNII TIESFSEDTM KNIFTPIVDW HFKSFETAQR
KYSRIIIAST MEVYLSAVMN FLPTPSKSHY LFNLRDLSRV VQGILLLQPR LVPPGLEGNQ
KIARLWIHEV YRVFCDRLVD EEDRNQFFRI IKHCVELQFK EKLNTLFSHI VEPGKLIVDE
DIRSLIFGDF ISKLKGNECL YDEIQNLEEL KRTVEHYLED FNLTSKTPMD LVIFHFAIEH
ISRISRVLKQ PNGHCLLVGV GGTGRQSVTR LAAFISDFEL FQIEITKNYS MNEWREDIRK
MMRRTGDLGV STVFLFGDHQ IKDESFLEDI NMMLNTGDIP NLFENEERLE IIEKMQTLCQ
KENIQIEFTP LNMYNKFIER IRQHLHIVLA FSPIGEAFRN RLRMFPSLIN CCTIDWFKAW
PEDALEMVAN KFLDDVEMST EIRSETVTMC KHFHESVRAL SQKYYEEMRR VNYVTPTCYL
ELIKTFKTLL GKQRLQILTL KNRYNVGLEK LQFSEGQINV MQTELLELQP KLIETSQETE
ELISIIERET IEVEDIKRIV EVDEAVANKA AQEAEAIKMD CEEKLSIAMP AMNAAVSALD
TLKQNDITIV KTMSNPPSGV KLVMESICIM KGIKPEKKTD PNGKQFEDYW PAAKKMLGDL
KFLESLKEYD KDHIPAPIIK KIRDKYITNK DFDPSIIKNV SSACEGLCKW VKAIDVYDSV
VKVVAPKRES LIAAEAVLNE QMEKLKVKQA ELKGVTDKLQ TLNDHLAQKQ IEKQNLEDNI
EMTKIKIDRA NKLINGLGGE KDRWTQNVDQ LSATYDNIIG DVLLSAGIVA YLGAFILDFR
QSCIQGWYQL CQHKNIPVSE LFSLSNTLGD PVKIRDWQIA GLPADQYSVD NAIIVTFCNR
WPLMIDPQSQ ANKWVKNMER ANKLEVIKLS HPNFLRTLEN CIQFGNPCLL ENIGEELDPI
LESVLLRQTF KQNNMEYIRL GDSLIEYSQD FKFYITTCLR NPHYLPEVSV KVTLINFMIT
PAGLEDQLLG LVAAKEKPDL EEKKNNLILE SAHNRHQLKD IEDKILEVLS MSKGNILEDE
TAIEILSSSK ALSIEISEKQ KIATKTEEEI DVTRNGYKPV AKHGSILFFT ISDLANIDPM
YQYSLAWFIH LYLQSISHSD HSTVLEERIQ NLNSHFTYSI YKNVCRSLFE KDKLLYSFLL
CIGLARGRGE VDGQEWRFLL TGGVALENPF SNPAPSWLSD KSWSEIVRAS QLPAFKGFME
MVQNSPNKWK SLYDSASPQE ENYTQLFGSS LTKLQELIVL RCLRPDKMIP AIQNFIVGQM
GQKYIEPPTF DLSLCYEDSS FFSPLIFVLS PGADPMASLY RFAEEKGMLP ASGAQSVTDT
NLNSGQELLK DIGEGKARNK LQTISLGQGQ GPIAERLILE AAESGTWVVL QNCHLAASWL
PELERICETI LTDADVTRDT FRLWLTSYPS SIFPVSVLQN GVKMTNEPPK GLRANLLRSY
LNDPISNTAF FNSSNKPQVF RKLLFGLCFF HALVQERRKF GPLGWNIPYE FNESDLRVSV
QQLQMFINKY EKTPLEALIY LTGECNYGGR VTDDLDRRLL LSLLKIFYCR NTIEDEQYRF
SDSGLYYVTV EGTYEHSLEY IRSLPLVPHP EVFGLHENAD ISKDQQETQL LFESIVLTLP
RQTSGGGKSS QEMIKELAQD ILQKIPQKFN LEEIQVKYKV NYMESMNTVL IQELIRFNNL
IHVIRNSLQD ICKAIKGLVV MSNELEDVFD SMMVGKVPSM WLAKSYPSLK PLGSYVTDLI
SRLAFFKEWI NGGTPTIFWI SGFYFTQSFL TGVLQNYARR FKIPIDHLNF EFEVTKYETS
VPQKPANGAY IRGLFMEGAR WSRQDHVIAE SLPKILYDQV PIIWLKPCER SKLVEKSYYS
CPGIFIEIVF SLWFIEMYLF FSNPF
//
