ID A0A2C9JIQ1_BIOGL Unreviewed; 1017 AA.
AC A0A2C9JIQ1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Solute carrier family 12 member 6 {ECO:0008006|Google:ProtNLM};
GN Name=106068750 {ECO:0000313|EnsemblMetazoa:BGLB003132-PE};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB003132-PE, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB003132-PE}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB003132-PE};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013083700.1; XM_013228246.1.
DR AlphaFoldDB; A0A2C9JIQ1; -.
DR EnsemblMetazoa; BGLB003132-RE; BGLB003132-PE; BGLB003132.
DR VEuPathDB; VectorBase:BGLB003132; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..253
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 360..640
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 654..767
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 786..1017
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 894..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 112490 MW; C17A456E4D8A1961 CRC64;
MTSFIEVMDS LCENAAQNKD NLPLADNEES MYNHMALYED DLTHHGKLSQ ILNRITSYQA
GITPNPNDIE KGTGKQIKKA NLGTILGVYL PCIQNIFGVL LFVRLTWIVG MAGTLEAFCI
VFICCSSTML TAFSMSAIAT NGVVPAGGSY FMISRSLGPE FGGAVGVLFY LGTSVASSMY
IVGAVEILVQ YMAPQMNQFG DVFNSYRLYG TVVLLLLAFI VFVGVGFVSK FAALSLACVI
ISILCIYIGI FVANPDTSLE VCMLGERLLE QDKVMFNGTF MCTKNITGPI YQHYCVDESN
TSSSCDYFNN PHTDVKVLKA IPGLSSGIFS KNIWNKYTQQ GKVIGTEQEG SETRGEIIAD
MTTSFMILIA IYFPSVTGIM AGSNRSGDLA DAQKSIPIGT IAAICTTSSV YLSCVLFFAG
CIDGNVMRDK YGASIGGSLI IGKLAWPHEW VILIGSFLST LGAGLQSLTG APRLLQAIAK
DGVIPFLRVF SITTKRGEPF RALLLTTFIS EIGVLIGNVD YIAPIITMFF LMCYGFVNMA
CALQTLLQTP NWRPRFRFYH WTLSLLGLAL CIVLMFISSW YYALAALAIA FCIYKYIEYK
GAEQEWGDGI RGLAMSAARY SLLRLQAGPP HTKNWRPQLL VLMKLDETLQ PKFPKLVLFA
SQLKAGKGLV LVNSVLEGNF RDRYPDAQAC KQTLHNLIKE YGVKGFCDVS VATDVSEGLC
QLIQNAGLGG LKHNTVVLGW PYGWRHDEDD RSYRVFLDTV RNVGSAQMCL LVPKGINQFP
DLGVKLKGTI DVWWIVHDGG LLMLLPFLLC QDRTWKNCKL RIFTVAQTED NSIQMKKDLQ
TYLYQLRITA DVDVVEMSNS DISAYTYERT LIMEQRTDML SKIRNAHRNN ANSSLAVPTI
TLSPVPEESS TDAPEPEQRS TDKSQYTFTP SEAKTLINKN KKPDKNNVRR MHTAVRLNEH
IVEKSHSAQL VILNLPAPPK SDSGAENYME FLEVLTEGIE RVLMVRGSGR EVITIYS
//
