ID A0A2C9JJ68_BIOGL Unreviewed; 2114 AA.
AC A0A2C9JJ68;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN Name=106057120 {ECO:0000313|EnsemblMetazoa:BGLB003293-PK};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB003293-PK, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB003293-PK}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB003293-PK};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013069645.1; XM_013214191.1.
DR STRING; 6526.A0A2C9JJ68; -.
DR EnsemblMetazoa; BGLB003293-RK; BGLB003293-PK; BGLB003293.
DR KEGG; bgt:106057120; -.
DR VEuPathDB; VectorBase:BGLB003293; -.
DR OrthoDB; 21929at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 1723..1930
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 321..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1976..1996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2049..2114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2064..2108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2114 AA; 236048 MW; C1CF7C3A946EF769 CRC64;
MSGTLALFRK TAGHGDIKKS AQKVADTKKD TVTRLKHLRI VLDNYDIQEA KKFFTDNYSH
IYYIFYDNFG TVEADLKQRA NKAHREELEG ILFIFEKILF LLPEIVHKRW MFHSIGRIIK
KLLHPGNSLQ LRSQGVRFFL IWYQCLQENA SEECHQMFTN LVPGLRDETN LESNPLVTDS
SLADGVGGIV AASEITAILP NQPEKIPENI TKYFLDTLLN YMVSEVIKIE WMNKEMREQS
FDFLFSKFKG KYLSQLLPDF VYRDIYDPIQ ELPMARGKEV MKKKDEPQAI SECRDSFIYW
LANFTVSSHK PDPDLHRGLS CSLLTEPPSH TGETRDVGKV AGDEEEGITP PVSGSKGSTL
SSDFAPNESA AGYCGEAHTD SEYQIVRAVL FSTRENVNTV HECFRQALLQ SFRHTNAIRK
VIGVYKEWFQ HEDERPVFML EPASVEPNTD GVDRGECAEF YHGSLSDIAE EDRFSMDDSP
SASALSLQHL NAPSENEDGA RRSYLRNRSY LGAVQDLADL GDEKSKDVRA GMQRILQVFI
TNAANIFLLD AEDDGQLQNQ VELCKRVLNI YRHVVMSIEL NHQTWEQLLK VLLRITSGVL
KRNPPIERYM TLGGRLAQPI FQTLIVTWTK ANLNIMVTAA LWDEFLAVLS ALTSWKELIM
EWSRTMETLT RVLARQVYGL DLNDLPLERL SEQKEKRRRG KESTKGKPTS SKTTGAGKLE
KSFSRGWSGS DGNSVNPLRS STNSAPSPEM TGSFERGAKY KSDGAGGKIR PDLSKQKSLS
GEPSPAHSRC PSSSSECLIR SSSEGNIIAD PHELLEKLRA SNPADIDDKS SCVLDTSRGS
NSNNLVETCS LSTSQGASAV VDDVEVSRIT TTCTAELSTI IGPHSILEEG SYEEGLNIDK
SGSRSPSPSS LQSKSGSRSP SPSNMLISND NNKDSSTPDR DSLHIDITGP EDSNVNRGLD
VSVDSIDEVK SIMAGGNVPG WMPDVAVVLW RRMLGCLGDV NKIEDPDIHA IVFDALEELL
DTLCRMSDNL GVTQDNMSSP QPPELIPPLH YFSSWLFECF NLSNRYKRGK LLAYQLICQA
MLRRHEVMPS PQLLAQFYLV LHTGLVSPDQ DIVNVLIRDC GHKFFSFPLP GCLLLTLDFI
KAAGSIISAV DHKEPPRAEA VTVLGSLLCY PHHLQEIPVL EPETMKTISI SSSELKNKVL
DLLLRAGKKE PAGLARCVAV SSVAIFLYGE LTHGTMHPKM KEAINVLLGA LMCVNKKVAK
VASDMLLLLC DHVDKLLDYH PQMPKKIAEA IASTISGLIP SHGLNINSDE EKRLIVWMMF
CMVEWCLKMP MPLLMETTDT DKSCIYKVFR VLHSAVTGHS SSSLTRVSKS LSDFLQDTDY
NNIWEQGVSM SAPQQRPFSA DTTLTDPLAD SAKQSSGGPQ VEPARKPETD IVKLAARALM
SHLVNHMSHF PMGSGAARLH TTVQEHHDLP EYVEEDLRTE IFSAPNVQFF VLNHRCLISF
IELPAVDAPG GGVTAGLMTA RTVCRIIVRD LCGKYCWENS VLYSPPWCTK GSSRHNAQTL
LGLAAGAELE PLLIQEENDV LYRLEPLKSL QLEAETDNLD MMLAHIGLTS PECLLRPGQP
LNIAARLPEE LTESAEVSLT KLIHQQAQIE KEHRNAHRKD IKHKRKRDSE HMVAQPEMPA
ESQDPVSPFQ MCRLLLDQMG LLSWEKRCHF DLLKKSEKVL RELKNLDSQK CRETHKIAVI
YIGQGQEDKN SILSNSSASR AFEDFVAGLG WEVDLETHQG FMGGLQQNRT TGNTAPYWAN
STCEVIFHVS TRIPSIGNDW HIKMRHLGND EVHIVWSEHS RDYRRGIIPT EFGDIVIIIY
PLPTGLYRIQ IDRKAEVPYF GPLFDGAIVD HYVLSGLVRA TAINASRLKR SSMPFYHAYY
EERAKCLETI IQQHTENTMF EDFAENVFAP VLPANAAIVD STLPSESSNN SLNEICQQGQ
TETSSQMSPN SSRQRGKLGL KNVGVAHAVS HLIFHHKLGG AAAVPKDHSA LVLAKKSIAT
HLSPRLENML LSPPTSRDYF TSSPPKEAHT KERSTLTPNK KESPMSSRKD HQAHSPSRRD
RHDTKPLKNL MISK
//
