ID A0A2C9JJQ4_BIOGL Unreviewed; 2143 AA.
AC A0A2C9JJQ4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN Name=106072854 {ECO:0000313|EnsemblMetazoa:BGLB003507-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB003507-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB003507-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB003507-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013088758.1; XM_013233304.1.
DR STRING; 6526.A0A2C9JJQ4; -.
DR EnsemblMetazoa; BGLB003507-RB; BGLB003507-PB; BGLB003507.
DR GeneID; 106072854; -.
DR KEGG; bgt:106072854; -.
DR VEuPathDB; VectorBase:BGLB003507; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 490..673
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 684..921
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1337..1512
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1545..1760
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 207..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2143 AA; 244730 MW; ABAC67A0E555D1AE CRC64;
MADATARSLQ YEYKANSNLV LSVDRTLIDR RARDEATGEV MSLVGKLTNT RMGDKALKSK
PPMMEERKLK RRKRDEAQHD MIKMKGTTLL SEGIDEMVGI LYRPKTTETR QTYEVLLNFI
QAALGDQPRD XLCGAADEVL IVLKNDRMKD KEKKKEVENL LGELADERFA LLVNLGKKIT
DWSQEEKVQT SETIDFDETY GVNVQFEESD DEDTGNLYGE VQEEGDGEED NEGEEAAFDA
TLHANLSEED KNKKDRGLQP REIDAFWIQR KISKFYPDDP NMAQSKANEV LEILKTAGDD
REAENKLVML LDVSHFEFIK VLRQNRQMIL YCTLLAQAQT ASEKKKIEQK MSNDPELSII
LKSLKATDQD DIVSEERARR QQARQSRVAA DIEAMDVDEE EEVGPVQTLY LEDLVFSQGS
HLMANKRCQL PDGSYRKQRK GYEEVHVPAL KPKPFDNEET LVSIDRLPKY AQAAFEGFKS
LNRIQSRLFQ AAIESDRNLL LCAPTGAGKT NVALLTIMRE IGKHVNADGT INADDFKIIY
IAPMKSLAQE MVGNFTERLS SYNLKVQELT GDHQLTREQI AATQVIVCTP EKWDIITRKG
GEKTYTQFVK LVIFDEIHLL HDDRGPVLES LVARTIRTIE TTQEDIRLVG LSATLPNYED
VAAFLRVDPR EGLFFFDNSF RPVPLEQQFI GITEKKAIKR FQLMNDIVYE KVIEHAGKNQ
VLVFVHSRKE TGKTARTIRD MCLEKDTLGL FMKEGSASTV VLRQEAEQVK SSELKDLLPY
GFAIHHAGMN KVDRKLVEDL FSDRHIQVLI STSTLAWGVN LPAHTVIIKG TQIYSPEKGR
WVELSALDVL QMLGRAGRPQ YDTKGEGIMI TNHSELQYYL SLMNQQLPIE SQFISKLADN
LNAEVVLGSI HNIKEAVDWL GYTYLYIRML RNPTLYGVSH DLLKEDPLLQ QRRKDLVHTA
ACMLDKNGLL KYDRKTGNLQ MTELGRIASH YYITNESMAT YNQLLKPTLS EIELFRVFSL
SSEFKYIVVR EEEKLELMKL LERVPIPIKE SIEELSAKVN VLLQAYISQL KLEGFALMVD
MVYITQSAGR LMRAIFEICL HHGWAQLVDK ALALCKMVDK RMWQSMTPLR QFRKIPDQVI
KKIEKKNFPF ERLYDLNHNE IGELLRLPKM GKPIHKYIRQ FPRLELSVHI QPITRSTLKV
ELTITPDFQW EEKLHGHSEA FWLLVEDVDS EAILHHEYFL LKSKFATDEH VLKFFVPVFE
PLPPQYFIRV ISDRWIGSET QLPVSFRHLI LPERYPPPTE LLDLQPLPIT ALRNPKFESL
YSKKFPIFNP IQTQVFNAIY NSDENVFVGA PTGSGKTICG EFAVLRMFSQ NPEGRCVYVA
PLDALAQQIY VDWHNKFAGI LGKKVVLLTG ETGTDLKLLA KGNIVISTPE KWDVLSRRWK
QRKNVQNVNL FIIDELHLIG GEVGPVLEVI CSRMRYISSQ LERNIRIVAL SSSLSNAKDV
AQWLGCPTSA FFNFHPNVRP VPLELHIQGF NVSHNASRVI AMAKPSYQAI IRHSPKKPVI
IFVPSRKQTK LTAIDILTCA AAEMQSGGDG KPYNRFLHVQ EEDLAPFLEK ITDLTLKETL
ANGVGYLHGG LSEIERKCVE QLFTSGAVQV VVVARGLAWG INVSAHLVIV MDTQYYDGKM
HSYEDYPAHD VLQMIGKANR PLLDKEGKAV IMCQSSKKEF FKKFLYEPLP VESHLDHCLH
DHFNAEIVTK TIENKQDAVD YLTWTFIYRR MTQNPNYYNL QGVSHRHLSD HLSEIVENTI
NDLEQSKCIN VEEDFDVYPL NLGMIAAYYY INYKTIELFS MSLNNKTKIK GLIEIVASAD
EYESMPIRHG EPTILKQLGS RLPNKITNAK FNDPHVKTNL LLQAHLSRMQ LSAELQSDTE
DILNKAIRLI QACVDVLSSN GWLSPALAAM ELAQMVTQAM WSKDSSLKQL PHFTADIIKR
CQEKNLESIF DIMEMEDKDR SELLQLSESE MADVARFCNR YPNIELTYEV QDKDSIRSGS
NINVTVTLER EDEITGPVIA PFFPQKREEG WWVVIGDPKN NSLLSIKRLT LQQKAKVKLD
FVAPAHGRYN YVIFFMSDAY MGCDQEYKFT VDVKEGESDS DSD
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