ID A0A2C9JM80_BIOGL Unreviewed; 1873 AA.
AC A0A2C9JM80;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein {ECO:0000259|SMART:SM01062};
GN Name=106059778 {ECO:0000313|EnsemblMetazoa:BGLB004695-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB004695-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB004695-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB004695-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR RefSeq; XP_013072911.1; XM_013217457.1.
DR STRING; 6526.A0A2C9JM80; -.
DR EnsemblMetazoa; BGLB004695-RB; BGLB004695-PB; BGLB004695.
DR KEGG; bgt:106059778; -.
DR VEuPathDB; VectorBase:BGLB004695; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1062..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1286..1320
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 542..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 442..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1530..1561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1726..1740
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1775..1790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1842..1862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 391
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 830
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1873 AA; 210686 MW; 434D08B881CAF1E5 CRC64;
DIDTGDEEDI RPCSFQSDSH GFRCQANIST CLGGWRGPNA GITSFDNIGY AMLTVFQCIT
MEGWTNVMYY TNDALGSTFN FLYFIPLIIL GSFFMLNLVL GVLSGEFAKE RERVENRRAF
FKLRRQQQIE RELNGYLEWI CKAEEVILSE ERTTDEEKLK IIEARRQAAA RKMKLLKAEE
NENDNEHNDN DLLASMTPGK NSMSCFLSQT SFRSDFIGKM FALRFWKIDV KGHTIYIGIY
VERYIIFKNI HYMDINRFNV ITIDCNLYNI KSLEMVLCCV VIVGSIVEVI WSEFKKGSSF
GISVLRALRL LRIFKVTRYW SSLRNLVISL LSSMRSILSL LFLLFLFIIV FALLGMQLFG
GEMNFEEGRP SAHFDTFPIA LLTVFQILTG EDWNEVMYNG IKAHGGIEKE GMFFSLYFIV
LVLFGNYTLL NVFLAIAVDN LANAQELTAA EEEQEAEEAR REELEKEMAE QFAAQGRPPL
VNICPPSPQN NEENKTANFN YTGNRVDINL SQNNLKDNRD KKITVATVVD AGIKTSSVTM
PLANNTEDDM SDTASTTSSG TADVPPRVTS QTENGGFTGP KPMLPYSSMF IFGPTNPIRR
FCHFVVNLRY FDLFIMIVIC ASSVALAAED PVFEESYKNK ILNYFDFVFT GVFTIELVLK
AVDLGIILHP GSYIRDLWNI LDATVVICAL VAFVFNALHS DSAGKNLNTI KSLRVLRVLR
PLKTINRVPK LKAVFDCVVN SLKNVSNILI VYILFQFIFA VIAVQLFKGR FFYCTDESKS
TREECQGQFF EYGVQSNQPT VKDREWLRQD FHYDNIMMAM LTLFTVTTGE GWPSVLKHSM
DSTSEDHGPK PVHRMEMSLF YVVFFIVFPF FFVNIFVALI IITFQEQGEN ELMDQEMDKN
QKQCIDFAIN AKPHCRFIPK NKNSVKYKIW QLVQSTKFEY FIMTLIALNT VVLMMKYEGQ
SDLYKTILTK LNEGFTALFT LECLLKIVGL GPRNYFYDPW NVFDFTTVIG SIIDVIITEI
LTKNVSFGFF RLFRAARLVK LLRQGYTIRL LLWTFFQSFK ALPYVCLLIL MLFFIYAIIG
MQVFGTIRLD SKTSINRHNN FRTFFAALTL LFRCATGEGW QQIMQSCLAG RPCDPESIGP
TDPADMAESG CGTNIAYIYF VSFIFLCSFL VSFDTATFQI GRIHYTDMYE MLRNMEPPVG
FGKKCPYKLA YRKLIRMNMP VAEDGTVHFT TTLFALIREC LIIKMGPAEI MDRRDDEMRE
TIRKLWPVQG KKMMDLLMPP SDELDEGKMS VGKIYAGLLI SENWKAYKAS QNASNNFKMR
REEKRPSLFR RLMGGMKSSG RSSQSLDSEH SDDNDGGGGG GNIAGAASNT GHSFLRRNSS
KRRKESDQKD NSNAQSMELK DIPSVSTQNI CENSLIAQTA NEITASLSKL NEPGADFSGG
LRPEHASSFI GRGDRSGARS PSLPTTPMSP RSPMGAASPF GSPRASPVPT RRSQSPRKFD
VGFAAAVTNL CEQAHSIADQ DRQKRFGMKE DSITSSSPTF RGRSRQRSRP PLQSQSPVLG
SPLPSPGLPR LRNMGDSGFY RSTSLETRSR SPSPNLTASP PLRSGSTSLI QRSRSPSPSM
IAASPPMINR QHRRLPMAPS STSSSGSGTT TTTSPAKPVT LNLSEPRYRN NIAIKDTLPV
RGAISPPGRG NINFPRLNAS PTHVPKLNIP VSATSSGTAV APIPPHHVRH APPPGRLSRP
EPYSPTERNN LNKPSEPSPS RSSTLPSAHR TSGYPHEEWG SRERLNEGGR DSRSLPQPSV
RSSSRSPDPR SGGQHEDNFM SASQAEGNSP HSRGRIVPNG FKHRGRKPEK YEMRSDSHTA
LHEDSDEDDD DWC
//
